Navigation Links
Breast Cancer Patients With Diabetes May Fare Worse
Date:1/20/2011

By Jenifer Goodwin
HealthDay Reporter

THURSDAY, Jan. 20 (HealthDay News) -- Having both breast cancer and diabetes greatly increases the chances of dying, new research shows.

Researchers conducted a meta-analysis, or pooled analysis, of previously published studies that looked at how breast cancer patients with diabetes fared.

Six of seven studies found pre-existing diabetes was associated with significantly higher long-term, all-cause mortality. Specifically, the studies showed breast cancer patients with diabetes were nearly 50 percent more likely to die than those who didn't have diabetes.

But much remains unknown, the study authors said, noting that it was premature to conclude that diabetes prevention or improved blood glucose control would lead to a better prognosis. The data didn't look at the specific causes of death, nor does the research establish whether having diabetes actually caused more breast cancer deaths.

"It's basically a signal that there may be a stronger association between diabetes and breast cancer mortality than we have appreciated," said lead study author Dr. Kimberly Peairs, an assistant professor of medicine at Johns Hopkins University School of Medicine in Baltimore. "The next step is to determine if there is causality between diabetes and breast cancer mortality."

The study, supported by grants from the U.S. National Institutes of Health, the American Cancer Society and the National Institute of Diabetes and Digestive and Kidney Diseases, is published in the January issue of the Journal of Clinical Oncology.

The reason why breast cancer patients with diabetes are more likely to do poorly isn't known, but several studies in the meta-analysis offer some clues.

One study, for example, found that women with type 2 diabetes tended to have their breast cancer diagnosed later than those without diabetes.

Women with pre-existing diabetes may also be sicker overall than women without diabetes. That may make them less able to handle the harsh chemotherapy drugs, or may prompt doctors to treat their cancer less aggressively because of concerns about their overall health, Peairs said.

One study the team reviewed showed that women with diabetes had more adverse events from chemotherapy, while another demonstrated that women with diabetes tended to receive less aggressive treatment, Peairs said.

There could also be a biological cause for the increased mortality risk. High levels of insulin may stimulate tumor growth, said Dr. Julia Smith, director of the breast cancer screening and prevention program at NYU Cancer Institute.

In people with type 2 diabetes, the cells become resistant to insulin, leading to rising blood sugar levels as well as more insulin circulating throughout the body.

"Insulin regulation, obesity and diabetes [are] critical in general health," Smith said. "I can't conclude that controlling insulin will modify anything about breast cancer, but it tells us we should be looking in those areas and there may be something very important."

About 24 million U.S. residents, or 8 percent of the adult population, had diabetes in 2007, according to background information in the article. Prior research also shows that diabetics are at a higher risk of developing breast cancer.

Women should seek to maintain a body mass index of about 25, limit consumption of animal fats, and exercise to prevent diabetes and reduce cancer risk, Smith said.

And women who already have diabetes should make sure they are controlling it, while oncologists and physicians treating patients with diabetes should make sure they are coordinating care, Peairs noted.

More information

The American Diabetes Association has more on living with diabetes.

SOURCES: Kimberly S. Peairs, M.D., assistant professor of medicine, Johns Hopkins University School of Medicine, Baltimore; Julia A. Smith, M.D., Ph.D., director, breast cancer screening and prevention program, NYU Cancer Institute, New York City; January 2011, Journal of Clinical Oncology


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Low forms of cyclin E reduce breast cancer drugs effectiveness
3. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
4. For Some Breast Cancer Patients, Shorter Radiation Works Well
5. Short-term radiation therapy successful on breast cancer
6. Few Women at High Risk for Breast Cancer Take Tamoxifen
7. Hormone May Prevent Aggressive Breast Cancer
8. MSU researcher linking breast cancer patients with alternative therapies
9. MRI May Not Add Value to Routine Breast Cancer Care
10. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
11. Businesses Rally Big Efforts to Benefit the Susan G. Komen Phoenix Affiliates Fight Against Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breast Cancer Patients With Diabetes May Fare Worse
(Date:12/8/2016)... ... December 08, 2016 , ... After enjoying ... opened registration today for its 33rd Annual Issues & Research Conference, March ... The theme of the conference is “Persistent Challenges and New Opportunities: Using Research ...
(Date:12/8/2016)... ... December 08, 2016 , ... CURE Media Group, the nation’s ... groups, has aligned with Upstage Lung Cancer in efforts to combat lung cancer, announced ... J. Hennessy, Jr said, “CURE Media Group is honored to team up with Upstage ...
(Date:12/8/2016)... ... December 08, 2016 , ... Launching of ... Unified Instance Manager architecture, meeting the needs of multichannel growth and doubling ... unattended auto-dialing system without agents, Presence Robodialer, provides greater operational capacity, administrative ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... surgery as possible. With this in mind, SIGVARIS has created a new line ... clot) during bed rest and provide the benefits of graduated compression when transitioning ...
(Date:12/8/2016)... ... 08, 2016 , ... The Dan Carlisle Agency, an Alabama-owned ... is announcing the launch of a charity drive to raise support and awareness ... and children in Birmingham has grown steadily since the 1980’s, and the Pathways ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... -- IRIDEX Corporation (NASDAQ: IRIX ) today announced ... stock, $0.01 par value (the "Offering" with such shares being ... terms of the Offering will depend on market and other ... no assurance as to whether or when the Offering may ... proceeds it will receive from this offering for working capital ...
(Date:12/8/2016)... 8, 2016 Global Interventional Radiology Market: ... global interventional radiology market analyzes the current and ... an elaborate executive summary, including a market snapshot ... sub-segments. The research is a combination of ... bulk of our research efforts along with information ...
(Date:12/8/2016)... -- Eli Lilly and Company (NYSE: LLY ) ... trial at the 9 th Clinical Trials on ... not meet the primary endpoint in the EXPEDITION3 clinical ... mild dementia due to Alzheimer,s disease (AD), and Lilly ... treatment of mild dementia due to AD. ...
Breaking Medicine Technology: