Navigation Links
Breast Cancer Gene Tests Won't Help Most Women: Report
Date:4/1/2013

MONDAY, April 1 (HealthDay News) -- The benefits of genetic testing to assess the risk of breast and ovarian cancers linked to the BRCA gene are limited to a small number of women, a new report indicates.

Mutations in the BRCA1 and BRCA2 genes greatly increase a woman's risk of developing these cancers. Women with these mutations have a 70 percent chance of developing breast cancer -- which is five times greater than in the general population -- and increase their lifetime risk of ovarian cancer from less than 2 percent to as high as 46 percent.

An important step in preventing these cancers is helping women understand their risk, according to the U.S. Preventive Services Task Force.

In preparing a draft report and recommendations, the task force examined available evidence to determine if genetic counseling and testing could benefit women most likely to have BRCA mutations.

The task force concluded that more than 90 percent of American women -- those whose family history does not indicate an increased risk for BRCA1 or BRCA2 mutations -- will not benefit from genetic testing or counseling.

This is because current tests often provide inconclusive results and these women could be burdened with the uncertainty of whether they are at increased risk for cancer. Many of these women might choose to take powerful medications or have major surgery to reduce their risk of cancer, which would be unnecessary if they were not at increased risk.

Therefore, the task force said it continues to recommend against genetic counseling and BRCA testing in these women.

"At this point, scientific evidence only shows that BRCA1 and BRCA2 testing is beneficial for women who have reviewed their family history of breast or ovarian cancer with a primary-care professional and discussed the pros and cons of the screening test with a trained genetic counselor," task force chairwoman Dr. Virginia Moyer said in task force news release.

"We hope that further research into ways to use genomic science, such as identifying women who have harmful BRCA genes but do not have a family history of cancer, could improve screening practices and even prevent some cancers," she added.

The task force said it also found evidence to recommend that primary-care health providers screen women who have family members with breast or ovarian cancer to determine if their family history is associated with an increased possibility of having BRCA1 or BRCA2 mutations.

In situations where this is the case, women should receive in-depth genetic counseling to thoroughly review family history and -- if indicated and after weighing the pros and cons of BRCA testing -- undergo the test, the report said.

The recommendations apply to women who have not been diagnosed with breast or ovarian cancer but who have family members with breast or ovarian cancer and whose BRCA status is unknown.

The draft report and recommendations will be open for public comment until April 29.

"Every year, too many American women and families are faced with the challenge of dealing with breast and ovarian cancer diagnosis and treatment," Moyer said. "We need better treatments, better screening methods and, most importantly, better ways to prevent cancer."

More information

The U.S. National Cancer Institute has more about BRCA mutations and cancer risk.

-- Robert Preidt

SOURCE: U.S. Preventive Services Task Force, news release, April 1, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Eliminating the good cholesterol receptor may fight breast cancer
2. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
3. Researchers develop a new cell and animal model of inflammatory breast cancer
4. Scientists uncover multiple faces of deadly breast cancer
5. Depo-Provera Birth Control Might Raise Breast Cancer Risk
6. Routine mammograms may result in significant overdiagnosis of invasive breast cancer
7. Mayo Clinic launches whole genome breast cancer study
8. Breast cancer patients suffer treatment-related side effects long after completing care
9. Teen Drinking May Boost Odds of Precancerous Breast Changes
10. Stress contributes to cognitive declines in women with breast cancer, researcher says
11. Breast Cancer Treatment Side Effects May Last for Years
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breast Cancer Gene Tests Won't Help Most Women: Report
(Date:6/25/2016)... , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on ... Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ability ... fumigation is not a common occurrence, but a necessary one in the event that lice ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the Frederick area economy by obtaining investment capital for emerging technology companies. ... years that have already resulted in more than a million dollars of capital ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 27, 2016 Jazz Pharmaceuticals plc (Nasdaq: ... the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ... Pharmaceuticals, Inc. ("Celator"; Nasdaq: CPXX ) expired ... Time). As previously announced on May 31, ... merger agreement under which Jazz Pharmaceuticals has commenced a ...
(Date:6/24/2016)... N.J. , June 24, 2016  Collagen ... the design, development and manufacturing of collagen and ... regeneration announced today that Bill Messer ... and Marketing to further leverage the growing portfolio ... medical devices. Bill joins the Collagen ...
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
Breaking Medicine Technology: