Navigation Links
Breast Cancer Gene Puts Survivors at Higher Odds for Recurrence
Date:12/8/2011

THURSDAY, Dec. 8 (HealthDay News) -- Breast cancer survivors carrying specific genetic mutations, known as BRCA1 or BRCA2, have a 10 percent greater risk for developing cancer in their other breast, and the risk rises further when a woman receives her first diagnosis before age 40, new research suggests.

"Our studies show that certain subgroups of women [with this mutation] who have already had cancers are also at risk for developing a second new cancer in their other breast, much more so than survivors who do not carry the mutation," Alexandra van den Broek, a doctoral candidate at the Netherlands Cancer Institute in Amsterdam, said in a news release from the San Antonio Breast Cancer Symposium.

For the study, the researchers analyzed information on about 5,000 women diagnosed with cancer in one of their breasts. Of these, 4.2 percent were carriers of the BRCA1 or BRCA2 mutation and were followed for about eight years on average. The investigators found that 8.6 percent of these women developed cancer in their other breast.

Overall, the 10-year risk of developing this new cancer among women who did not carry the mutation was 6 percent compared with 17.9 percent for those who did carry the mutation, the study revealed.

The 10-year risk jumped to 26 percent among carriers who were diagnosed with their first breast cancer before the age of 40 years. For women diagnosed between ages 40 and 50, the risk was 11.6 percent.

Women who carried the BRCA mutation and whose first tumor was "triple-negative" had a new-cancer risk of 19 percent within the next 10 years, compared with 11 percent for other women with the BRCA mutation. A triple-negative tumor is one that has none of the three receptors -- estrogen receptors, progesterone receptors and human epidermal growth factor receptor 2 (HER2) -- that occur in most breast cancers.

"Guidelines for prophylactic measures and screening in the follow-up of patients with breast cancer carrying the BRCA1 or BRCA2 mutation are important to provide patients with the best information and counseling," van den Broek said in the release. "If these results are confirmed, [it will be] possible to personalize the guidelines for these specific subgroups."

The study is slated for presentation Thursday at the 2011 San Antonio Breast Cancer Symposium. Data and conclusions of this study should be viewed as preliminary until published in a peer-reviewed journal.

More information

The U.S. National Cancer Institute has more about BRCA1 and BRCA2.

-- Mary Elizabeth Dallas

SOURCE: San Antonio Breast Cancer Symposium, news release, Dec. 8, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Two New Drug Combos May Fight Advanced Breast Cancers
2. Family Tree May Affect Diagnosis Age in Some Breast Cancers
3. Mayo Clinic: Obese patients with HER2-positive breast cancer may have worse outcomes
4. Hispanic Women More Likely to Die of Breast Cancer
5. Obesity Linked to Worse Outcomes With Early Breast Cancer
6. Avastin Boosted Survival for Type of Aggressive Breast Cancer: Study
7. Contralateral prophylactic mastectomy offers limited gains for breast cancer patients
8. Bone Drugs May Also Battle Breast Cancer, Researchers Say
9. Oral bisphosphonate did not improve prognosis for patients with breast cancer
10. Expert Panel Pinpoints Environmental Culprits in Breast Cancer
11. Targeted Radiation May Not Be Better for Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breast Cancer Gene Puts Survivors at Higher Odds for Recurrence
(Date:6/24/2016)... Diego, CA (PRWEB) , ... June 24, 2016 , ... ... with the American Cancer Society and the Road To Recovery® program to drive cancer ... to seniors and other adults to ensure the highest quality of life and ongoing ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the Frederick area economy by obtaining investment capital for emerging technology companies. ... years that have already resulted in more than a million dollars of capital ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) sponsors Luke’s ... June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. ... helping service members that have been wounded in battle and their families. Venture Construction ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today that ... Supplier Horizon Award . One of ... was recognized for its support of Premier members through ... clinical excellence, and commitment to lower costs. ... this recognition of our outstanding customer service from Premier," ...
(Date:6/23/2016)... Research and Markets has announced the addition ... States, China, Japan, Brazil, United Kingdom, Germany, France, Italy, ... Surgical Procedure Volumes: Global ... surgical procedure volume data in a geographic context. The ... of growth drivers and inhibitors, including world population growth, ...
(Date:6/23/2016)... NEW YORK , June 23, 2016 ... rough waters, but it continues to present great opportunities ... featured companies for today: Intrexon Corp. (NYSE: ... ), Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), ... Learn more about these stocks and receive your complimentary ...
Breaking Medicine Technology: