Navigation Links
Breast Cancer Gene Puts Survivors at Higher Odds for Recurrence
Date:12/8/2011

THURSDAY, Dec. 8 (HealthDay News) -- Breast cancer survivors carrying specific genetic mutations, known as BRCA1 or BRCA2, have a 10 percent greater risk for developing cancer in their other breast, and the risk rises further when a woman receives her first diagnosis before age 40, new research suggests.

"Our studies show that certain subgroups of women [with this mutation] who have already had cancers are also at risk for developing a second new cancer in their other breast, much more so than survivors who do not carry the mutation," Alexandra van den Broek, a doctoral candidate at the Netherlands Cancer Institute in Amsterdam, said in a news release from the San Antonio Breast Cancer Symposium.

For the study, the researchers analyzed information on about 5,000 women diagnosed with cancer in one of their breasts. Of these, 4.2 percent were carriers of the BRCA1 or BRCA2 mutation and were followed for about eight years on average. The investigators found that 8.6 percent of these women developed cancer in their other breast.

Overall, the 10-year risk of developing this new cancer among women who did not carry the mutation was 6 percent compared with 17.9 percent for those who did carry the mutation, the study revealed.

The 10-year risk jumped to 26 percent among carriers who were diagnosed with their first breast cancer before the age of 40 years. For women diagnosed between ages 40 and 50, the risk was 11.6 percent.

Women who carried the BRCA mutation and whose first tumor was "triple-negative" had a new-cancer risk of 19 percent within the next 10 years, compared with 11 percent for other women with the BRCA mutation. A triple-negative tumor is one that has none of the three receptors -- estrogen receptors, progesterone receptors and human epidermal growth factor receptor 2 (HER2) -- that occur in most breast cancers.

"Guidelines for prophylactic measures and screening in the follow-up of patients with breast cancer carrying the BRCA1 or BRCA2 mutation are important to provide patients with the best information and counseling," van den Broek said in the release. "If these results are confirmed, [it will be] possible to personalize the guidelines for these specific subgroups."

The study is slated for presentation Thursday at the 2011 San Antonio Breast Cancer Symposium. Data and conclusions of this study should be viewed as preliminary until published in a peer-reviewed journal.

More information

The U.S. National Cancer Institute has more about BRCA1 and BRCA2.

-- Mary Elizabeth Dallas

SOURCE: San Antonio Breast Cancer Symposium, news release, Dec. 8, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Two New Drug Combos May Fight Advanced Breast Cancers
2. Family Tree May Affect Diagnosis Age in Some Breast Cancers
3. Mayo Clinic: Obese patients with HER2-positive breast cancer may have worse outcomes
4. Hispanic Women More Likely to Die of Breast Cancer
5. Obesity Linked to Worse Outcomes With Early Breast Cancer
6. Avastin Boosted Survival for Type of Aggressive Breast Cancer: Study
7. Contralateral prophylactic mastectomy offers limited gains for breast cancer patients
8. Bone Drugs May Also Battle Breast Cancer, Researchers Say
9. Oral bisphosphonate did not improve prognosis for patients with breast cancer
10. Expert Panel Pinpoints Environmental Culprits in Breast Cancer
11. Targeted Radiation May Not Be Better for Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breast Cancer Gene Puts Survivors at Higher Odds for Recurrence
(Date:3/24/2017)... ... March 24, 2017 , ... The Radiology Business Management Association (RBMA) ... annual awards, now in their 12th year, are among the most prestigious in radiology ... 2016, the awards were retooled to recognize achievements in both large budget (over $5,000) ...
(Date:3/24/2017)... Arizona (PRWEB) , ... March 24, 2017 , ... ... Healing Center, Sedona, Arizona’s Premier Center for Shamanic Healing and Spiritual Awakening, ... Luis Delgado, June 9--24, 2017. This sacred and spiritual journey during the ...
(Date:3/24/2017)... ... ... The law firm of Enea, Scanlan & Sirignano, LLP, with ... C. Enea has joined the firm as an associate attorney. Ms. Enea, who previously ... law, Medicaid planning and applications, and Wills, Trusts and Estates. Samantha A. Lyons, ...
(Date:3/24/2017)... ... March 24, 2017 , ... “Finding Christ Through Social ... devotional journal chronicling the writer’s path toward true communion with God. “Finding Christ ... #TruthwithGrace” is the creation of published author Lea Michelle Johnson, a follower of ...
(Date:3/23/2017)... ... March 23, 2017 , ... In 2016 the World Health Organization ... could be four million Zika-related cases in the Americas within the next year. Lyme ... cases reported per year skyrocketing to an estimated 329,000. Yet, Zika, Lyme and other ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... YORK , March 24, 2017 ... ... a leading publisher of cannabis market research, the legal cannabis ... percent CAGR through 2021, despite conflicting signals from the current ... points out that the two biggest drivers of growth in ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... report to their offering. ... The Deep Learning: Drug Discovery and Diagnostics Market, 2017-2035 ... market of deep learning solutions within the healthcare domain. Primarily driven ... a novel solution to generate relevant insights from medical data. ...
(Date:3/24/2017)... -- Today Stock-Callers.com have issued research reports on ... (NASDAQ: NVCN), Hologic Inc. (NASDAQ: HOLX), Edwards Lifesciences Corp. (NYSE: ... These companies are part of the Healthcare sector, which gave ... rd , 2017, with the NYSE Health Care Index declining ... in the S&P 500 were down about 0.4% as a ...
Breaking Medicine Technology: