Navigation Links
Breast Cancer Drugs May Fight Cervical Cancer, Too
Date:11/9/2009

Study in mice reports success with drugs that inhibit estrogen,,

MONDAY, Nov. 9 (HealthDay News) -- Two drugs used to treat breast cancer and osteoporosis eliminated cervical cancer in mice, according to a new study.

The drugs also cleared precancerous growths in the cervix and vagina, and prevented the onset of cancer in mice with precancerous lesions.

The breast cancer drug fulvestrant and the breast cancer/osteoporosis drug raloxifene were given to mice genetically engineered to carry human papillomavirus (HPV) 16, which is strongly associated with cervical cancer. Both drugs prevent estrogen from working in cells. Fulvestrant is marketed for women as Faslodex, and raloxifene is marketed as Evista.

The study appears in this week's issue of the Proceedings of the National Academy of Sciences.

"We have begun to test whether the drugs are as effective in treating cervical cancer in human cells as they are in our mice," senior study author Dr. Paul F. Lambert, an oncology professor at the University of Wisconsin School of Medicine and Public Health, said in a university news release.

If the lab studies, expected to take one or two years, are successful, they could be followed quickly by clinical trials, the researchers said.

Nearly all cervical cancers test positive for HPV 16, Lambert said, but not all women infected with HPV get cervical cancer, which has led researchers to examine other factors.

"Since the cervix and other female reproductive organs are so responsive to estrogen, our lab and others began to focus on that hormone," he explained.

Fulvestrant and raloxifene block a receptor (estrogen receptor alpha) that mediates estrogen function in cells.

"We can't be sure how the science will translate from animals to humans, but we have faith in our mouse model," Lambert said. "There are many similarities in how cervical cancer develops and manifests itself in women and in mice."

More information

The U.S. National Women's Health Information Center has more about cervical cancer.



-- Robert Preidt



SOURCE: University of Wisconsin, news release, Nov. 9, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Survival differences by race most apparent in advanced stages of breast cancer
2. MRI finds breast cancer before it becomes dangerous
3. Pathway links inflammation, angiogenesis and breast cancer
4. Drop in breast cancer incidence linked to hormone use, not mammograms
5. Breast cancer prevention practices vary across Canada
6. Eating junk food whilst pregnant and breastfeeding may lead to obese offspring
7. Acrylamide Wont Raise Breast Cancer Risk
8. New link between estrogen and breast cancer
9. Hypnosis Eases Pain of Breast Cancer Surgery
10. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
11. Longaberger Expands Horizon of Hope Campaign to Build Support for American Cancer Societys Breast Cancer Initiatives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/26/2016)... Charlotte, NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind ... able to be personalized through a fitness app. The fitness app plans to fix the ... solutions currently only offer a one size fits all type program , They ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, ... work on several important health care topics including advance care planning, healthcare costs ...
(Date:6/25/2016)... ... ... of Bruton Memorial Library on June 21 due to a possible lice infestation, as reported ... head lice: the parasite’s ability to live away from a human host, and to infest ... in the event that lice have simply gotten out of control. , As lice are ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the largest ... as the Medical Director of its new Mesquite-Samuell Farm facility. , “We are ... Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on the ... announced that patient enrollment in its ongoing randomized ... has exceeded 50% of its 24-patient target. Capricor ... the third quarter of 2016, and to report ...
(Date:6/23/2016)... RIDGE, Ill. and INDIANAPOLIS ... of students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship ... The 2016 scholarship winners, announced today online at ... to let type 1 diabetes stand in the way ... Diabetes has supported the Foundation,s scholarship program since 2012, ...
(Date:6/23/2016)... Pa. , June 23, 2016 The ... in an outpatient dialysis facility.  Treatments are usually 3 ... 6 hours per visit, including travel time, equipment preparation ... a patient, but especially grueling for patients who are ... of a skilled nursing and rehabilitation centers for some ...
Breaking Medicine Technology: