Navigation Links
Breast Cancer Drug Might Treat Bipolar Disorder
Date:3/3/2008

Tamoxifen may ease condition's mania phase, but side effects could be a problem, experts say

MONDAY, March 3 (HealthDay News) -- A drug commonly used to treat breast cancer may one day help manage symptoms of mania, or the "high" phase experienced by people with bipolar disorder, researchers say.

Men and women who took tamoxifen for three weeks experienced a significant lessening of their mania compared to people taking a placebo, the study found.

Whether or not tamoxifen will become a mainstay of treatment for bipolar disorder remains to be seen, however.

"The bad news is [that] this is something we would have to figure out how side effects are going to be a factor in long-term use," said one expert, Dr. Jane Ripperger-Suhler, assistant professor of psychiatry and behavioral science at Texas A&M Health Science Center College of Medicine and a psychiatrist with Scott & White Mental Health Center. "The good news is that people are thinking outside the box in terms of what might be effective for a particular disorder."

"More trials need to be conducted," added Dr. Ma-Li Wong, professor of psychiatry and vice chair for translational research at the University of Miami Miller School of Medicine. "Tamoxifen is not a drug that is without side effects. One needs to be careful in terms of drawing conclusions. Bipolar is not a short-term disorder and in clinical trials for breast cancer, you're talking about treatment of five years. Also, the dose used in this study is a bit high in comparison to that used in breast cancer."

The findings, by researchers at Dokuz Eylül University Medical School in Izmir, Turkey, are published in the March issue of Archives of General Psychiatry.

Tamoxifen helps suppress breast cancer by interfering with the action of the female hormone estrogen in the body.

The drug also inhibits the activity of a family of enzymes known as protein kinase C (PKC). Activity of PKC may be altered during the mania state of bipolar disorder, experts say. Existing drugs for the condition, including lithium and valproate sodium, inhibit PKC-associated signaling in the brain.

Previous animal studies as well as pilot trials in humans have suggested that tamoxifen might be effective in treating bipolar-related mania.

For the new study, 66 men and women with bipolar disorder and currently in a manic state, or mixed states that included mania, were randomly assigned to take 40 to 80 milligrams of tamoxifen a day or a placebo for up to three weeks.

Participants were also given up to 5 milligrams a day of the sedative lorazepam as needed.

Fifty patients completed the study.

At the end of three weeks, participants taking tamoxifen had significantly lower scores on tests used to measure the severity of mania, with 48 percent of them citing a reduction of at least half in their mania scores.

Those in the placebo group had slightly increased mania scores, and only 5 percent experienced a reduction of at least half in their mania scores.

Twenty-eight percent of those in the tamoxifen group reached the cut-off scores for remission from mania, compared to none in the placebo group, the researchers said.

More information

The U.S. National Institute of Mental Health has more on bipolar disorder.



SOURCES: Jane Ripperger-Suhler, M.D., assistant professor, psychiatry and behavioral science, Texas A&M Health Science Center College of Medicine, and psychiatrist, Scott & White Mental Health Center, Temple; Ma-Li Wong, M.D., professor of psychiatry and vice chair for translational research, University of Miami Miller School of Medicine; March 2008, Archives of General Psychiatry


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New study of targeted therapies for breast cancer -- model for global clinical trials
2. Weill Cornell team identifies potential new drug targets against hormone-dependent breast cancer
3. Atypical protein kinase C stabilizes SRC-3 levels in breast cancer cells
4. Breast cancer death rates among black women not decreasing across all states
5. Breast cancer subtypes linked to survival from secondary brain tumors
6. Novartis and Sony Pictures Television Internationals Latin American Advertising Sales Group Launch Partnership to Create Multi-Media Platform for Breast Cancer Awareness, Detection, and Treatment in Latin America
7. Representative Greg Harris, Senator Jacqueline Collins, Senator Iris Martinez and Fellow State Legislators to Join Susan G. Komen for the Cure in Announcing Groundbreaking Legislation to Reduce Breast Cancer Disparities; Will Hold Press Conference Friday
8. Cost of Breast Cancer Can Include Paycheck
9. Photo: Beverly Hills Liposculpture Specializes in Scarless Breast Reduction Dr. Alan Bittner Reduces Female Breasts by up to 50%
10. Hormone therapy increases frequency of abnormal mammograms, breast biopsies
11. LA BioMed study finds hormone therapy increases frequency of abnormal mammograms, breast biopsies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breast Cancer Drug Might Treat Bipolar Disorder
(Date:6/26/2016)... Carolina (PRWEB) , ... June 26, 2016 , ... ... of a new product that was developed to enhance the health of felines. The ... centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand ... project," said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s ... within Final Cut Pro X . Simply select a ProHand generator and drag ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the ... (United States, China, Japan, Brazil, United Kingdom, Germany, France, ... Surgical Procedure Volumes: ... provides surgical procedure volume data in a geographic context. ... analysis of growth drivers and inhibitors, including world population ...
(Date:6/23/2016)... , June 23, 2016 ... but it continues to present great opportunities to investors. ... for today: Intrexon Corp. (NYSE: XON ), ... Pharmaceuticals Inc. (NASDAQ: ARNA ), and Regeneron ... about these stocks and receive your complimentary trade alerts ...
(Date:6/23/2016)... SAN DIEGO , June 23, 2016 /PRNewswire/ ... advancing programs that address medical conditions resulting from ... that it has appointed Greg Doyle ... member of Leading BioSciences, executive management team and ... officer and chief financial officer. He will provide ...
Breaking Medicine Technology: