Navigation Links
Breast Cancer Drug May Beat Fungal Infection

If proven effective, tamoxifen could be new way to fight Candida,,

FRIDAY, July 24 (HealthDay News) -- A drug used to help prevent recurring breast cancer appears to hold promise as a treatment for deadly fungal infections, new research has found.

University of Rochester Medical Center researchers found that tamoxifen kills yeast in mice with Candida infections, which can be fatal to people with compromised immune systems, including people with cancer or HIV and those taking immunosuppressants for chronic conditions.

At extremely high levels, tamoxifen slashed yeast levels by 150-fold, causing most fungus cells to break up and die while halting surviving cells from progressing into a disease-causing state, their study found.

"It's still early, but if tamoxifen, or molecules like it, turns out to be an effective treatment against serious fungal infections, it'll be a welcome addition to our arsenal," Dr. Damian Krysan, an assistant professor of pediatrics at the university and an author of the study, said in a university news release.

The results are published in the August issue of Antimicrobial Agents and Chemotherapy.

Available antifungal medications pose some issues for people who need them the most, according to background information in the news release. The only new class of antifungals approved for use in the past two decades is generally effective, but they can only be taken intravenously, which poses logistic and other problems for some patients. And the most common oral antifungal medication only slows fungus cell growth, making it difficult for immune-compromised patients to completely shake their infections.

"We don't have vaccines against fungal infections, and the few drugs we do have aren't always effective," Krysan said. "We've got a lot more work to do to figure out whether tamoxifen could be used in high doses or whether it could be used in combination with other treatments, but we're excited about the possibility of giving doctors another way to help these critically ill patients."

More information

The U.S. Centers for Disease Control and Prevention has more about Candidiasis.

-- Kevin McKeever

SOURCE: University of Rochester Medical Center, news release, July 20, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Culture May Help Raise Breast Cancer Death Rate for American Indians
2. Breast cancer research highlights from the American Association of Physicists in Medicine meeting in Anaheim, July 26-30
3. Look Good...Feel Better Launches Salon Awareness Campaign During National Breast Cancer Awareness Month
4. Elevated Insulin Levels Linked to Breast Cancer
5. Survey Reveals Women Arent Doing All They Can to Support Breast Health
6. HIV Drugs Provide Breast-Fed Babies With Some Protection
7. Nexavar in Combination with Chemotherapy Shown to Extend Progression-Free Survival in Patients with Advanced Breast Cancer
8. The Maurer Foundation for Breast Health Education Launches Integrated Rebranding Operation
9. New Gene May Signal Aggressive Breast Cancer
10. RI Hospital first in country to enroll patient in new study for recurrent chest wall breast cancer
11. Breast cancer drug shows promise against serious infections
Post Your Comments:
Related Image:
Breast Cancer Drug May Beat Fungal Infection
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term ... long-term care insurance companies have a waiver for care if the client has a ... when the family pays for care, is often waived, so the benefits from their ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released ... understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture ... Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that is ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: ... “America On The Brink” is the creation of published author, William Nowers. ... As a WWII veteran, he spent thirty years in the Navy. Following ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided an update ... Puerto Rico , where the company manufactures ... Following a comprehensive onsite assessment, the ... temporary loss of power and minimal water damage due ... have resumed, and the company expects to return to ...
(Date:10/7/2017)... --  Provista, a proven leader in the supply ... power, today announced a new resource area on ... is the online home for case studies, articles on ... releases, slideshows and events. ... at their fingertips, viewers can also watch short videos ...
(Date:10/4/2017)... 2017  According to the Centers for Disease Control and Prevention (CDC), ... PhysicianOne Urgent Care is helping communities across Massachusetts , ... by offering no-cost* flu shots through the end of the month. ... insurance regulations. ... get a flu shot is by the end of October, according to ...
Breaking Medicine Technology: