Navigation Links
Breast Cancer Drug May Beat Fungal Infection
Date:7/24/2009

If proven effective, tamoxifen could be new way to fight Candida,,

FRIDAY, July 24 (HealthDay News) -- A drug used to help prevent recurring breast cancer appears to hold promise as a treatment for deadly fungal infections, new research has found.

University of Rochester Medical Center researchers found that tamoxifen kills yeast in mice with Candida infections, which can be fatal to people with compromised immune systems, including people with cancer or HIV and those taking immunosuppressants for chronic conditions.

At extremely high levels, tamoxifen slashed yeast levels by 150-fold, causing most fungus cells to break up and die while halting surviving cells from progressing into a disease-causing state, their study found.

"It's still early, but if tamoxifen, or molecules like it, turns out to be an effective treatment against serious fungal infections, it'll be a welcome addition to our arsenal," Dr. Damian Krysan, an assistant professor of pediatrics at the university and an author of the study, said in a university news release.

The results are published in the August issue of Antimicrobial Agents and Chemotherapy.

Available antifungal medications pose some issues for people who need them the most, according to background information in the news release. The only new class of antifungals approved for use in the past two decades is generally effective, but they can only be taken intravenously, which poses logistic and other problems for some patients. And the most common oral antifungal medication only slows fungus cell growth, making it difficult for immune-compromised patients to completely shake their infections.

"We don't have vaccines against fungal infections, and the few drugs we do have aren't always effective," Krysan said. "We've got a lot more work to do to figure out whether tamoxifen could be used in high doses or whether it could be used in combination with other treatments, but we're excited about the possibility of giving doctors another way to help these critically ill patients."

More information

The U.S. Centers for Disease Control and Prevention has more about Candidiasis.



-- Kevin McKeever



SOURCE: University of Rochester Medical Center, news release, July 20, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Culture May Help Raise Breast Cancer Death Rate for American Indians
2. Breast cancer research highlights from the American Association of Physicists in Medicine meeting in Anaheim, July 26-30
3. Look Good...Feel Better Launches Salon Awareness Campaign During National Breast Cancer Awareness Month
4. Elevated Insulin Levels Linked to Breast Cancer
5. Survey Reveals Women Arent Doing All They Can to Support Breast Health
6. HIV Drugs Provide Breast-Fed Babies With Some Protection
7. Nexavar in Combination with Chemotherapy Shown to Extend Progression-Free Survival in Patients with Advanced Breast Cancer
8. The Maurer Foundation for Breast Health Education Launches Integrated Rebranding Operation
9. New Gene May Signal Aggressive Breast Cancer
10. RI Hospital first in country to enroll patient in new study for recurrent chest wall breast cancer
11. Breast cancer drug shows promise against serious infections
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breast Cancer Drug May Beat Fungal Infection
(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... ... marketing services, which specializes in thought leadership , media relations, social media, ... and services that will be powered through Act-On, an intuitive marketing automation platform. ...
(Date:2/24/2017)... ... February 24, 2017 , ... ... once again hosted their Military Wedding Giveaway, with the winning couple announced on ... Farms with services generously donated from local vendors: A Matter of Taste, Ryan ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... Justice jointly issued a letter to withdraw previous guidance issued by ... gender identity. The guidance issued in May 2016 by the Obama Administration came ...
(Date:2/23/2017)... ... February 23, 2017 , ... The ... funding innovative lymphoma research and serving the lymphoma community through a comprehensive series ... La Gorce Country Club in Miami Beach to host its Swirl: Miami Wine ...
(Date:2/23/2017)... Chapel Hill, NC (PRWEB) , ... February 23, 2017 , ... ... the Platinum Sponsor for ACPA’s 74th Annual Meeting. KLS is a longtime supporter ... in 2017 as an exhibitor and Platinum Sponsor," said Dr. Bob Havlik, 2017 ACPA ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... , Feb. 24, 2017 Research and Markets ... Analysis & Trends - Industry Forecast to 2025" report to ... ... CAGR of around 23.8% over the next decade to reach approximately ... market estimates and forecasts for all the given segments on global ...
(Date:2/24/2017)... Research and Markets has announced the addition of the ... offering. ... Hemophilia Drugs Price Analysis and Strategies - 2016, provides drug pricing data ... following questions: What are the key drugs ... the Global Hemophilia market? What are the unit prices ...
(Date:2/24/2017)... -- In conjunction with DURECT Corporation,s (Nasdaq: DRRX ... are invited to listen to a conference call that ... March 14, 2017 at 4:30 pm Eastern Time (1:30 ... of the presentation will be available by accessing DURECT,s ... If you are unable to participate during the live ...
Breaking Medicine Technology: