Navigation Links
Breast Cancer Drug May Also Help Lung Cancer Patients
Date:1/24/2011

By Amanda Gardner
HealthDay Reporter

MONDAY, Jan. 24 (HealthDay News) -- The anti-estrogen drug that transformed the treatment of breast cancer three decades ago may also reduce the risk of dying from lung cancer, researchers say.

In a study published in the Jan. 24 online edition of the journal Cancer, tamoxifen lowered the risk of dying from lung cancer among women who already had breast cancer. However, the results are too preliminary to warrant giving tamoxifen to lung cancer patients.

"There aren't a whole lot of clinical implications, but it does provide more evidence to our accumulating knowledge that female sex hormones are involved in some way, shape or form in lung cancer progression," said Dr. Apar Kishor Ganti, assistant professor of oncology-hematology at the University of Nebraska Medical Center in Omaha. "Whether or not it's a cause is a little sketchy."

Ganti was not involved with the study.

Prior studies had indicated that taking hormone replacement therapy during menopause upped a woman's chances of dying from lung cancer.

So these researchers hypothesized that the opposite might be true -- that anti-estrogens might lower a woman's risk of death from lung cancer.

Previous studies have also indicated that lung cancers, like breast and gynecological cancers, express hormone receptors.

In the current study, Dr. Elisabetta Rapiti, from the Geneva Cancer Registry, and colleagues reviewed records of 6,655 women diagnosed with breast cancer in Switzerland between 1980 and 2003. Just under half (46 percent) received anti-estrogen therapy which, during that time period, was most likely tamoxifen (aromatase inhibitors were not yet in use in Switzerland, the authors stated).

Women taking anti-estrogen therapy had an 87 percent decreased risk of death from lung cancer, compared to women who weren't taking this type of therapy.

There was no link between anti-estrogen therapy and whether or not a woman actually developed lung cancer.

One limitation to the research, Ganti noted, is that only 40 women actually developed lung cancer, so it was a very small study group.

The estrogen receptors implicated in lung cancer "don't seem to discriminate between men and women," Ganti said, indicating that anti-estrogens might have the same effect in men, although it's too early to state this definitively.

Other than breast and gynecological cancers, such as ovarian cancers, lung cancer has been the most extensively studied with regard to its interplay with estrogen, said Jing Peng, a post-doctoral associate in the Cancer Prevention Program at Fox Chase Cancer Center in Philadelphia.

There is limited evidence that estrogen may play a role in head-and-neck cancers as well.

But the issue is a complicated one, with some studies in mice suggesting that tamoxifen might actually promote lung cancer, Peng said.

"This article at least verifies that further studies should be carried out," she said.

More information

The U.S. National Cancer Institute has more on lung cancer.

SOURCES: Apar Kishor Ganti, M.D., assistant professor, oncology-hematology, University of Nebraska Medical Center, Omaha, Neb.; Jing Peng, Ph.D., post-doctoral associate, Cancer Prevention Program, Fox Chase Cancer Center, Philadelphia; Jan. 24, 2011, Cancer, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Breast Cancer Patients With Diabetes May Fare Worse
2. Strong social ties benefit breast cancer patients
3. Breastfeeding -- added protection for cancer survivors?
4. Small Spreads of Breast Cancer May Not Affect Survival
5. U-M researchers find indirect path to attack breast cancer stem cells
6. Scientists identify avoidable breast cancer risk factors
7. Breast Cancer Radiation Before 1984 Tied to Heart Disease
8. Study Finds Racial Disparity in Breast Cancer Outcomes
9. Study provides molecular rationale for combining targeted agents to treat breast cancer
10. Preoperative breast MRI suggests high cancer yield
11. Quality of life measures in breast cancer clinical trials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breast Cancer Drug May Also Help  Lung Cancer Patients
(Date:5/26/2017)... ... May 26, 2017 , ... The ... seminar to focus on current legislative activity and the latest regulatory concerns impacting ... p.m. Sunday, Sept. 10, and will continue through Monday, Sept. 11, at the ...
(Date:5/26/2017)... , ... May 26, 2017 , ... ... delicatessen foods, is sharing bold recipes for Memorial Day entertaining that are sure ... , “Boar’s Head fresh sliced meats and cheeses featured in these refreshingly ...
(Date:5/26/2017)... ... May 26, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... focusing on the Peace Agreements being discussed by President Donald Trump and the rest ... to try to speed up peace talks in the continuous battle between Israel and ...
(Date:5/26/2017)... ... 26, 2017 , ... “When the Stars Lead Home”: a poignant story of ... author Laura Weigel Douglas, an avid reader who lives in the Pacific Northwest with ... like Green Hills Adventure Camp. She couldn’t be more grateful. , Twelve-year old Tizzy ...
(Date:5/26/2017)... ... May 26, 2017 , ... “Cactus Jack: Against All Odds”: the story of ... “Cactus Jack: Against All Odds” is the creation of published author, Walter Hubbard, a ... to Jack Carlisle’s third child Jane. Walter. Walter and Jane have three adult ...
Breaking Medicine News(10 mins):
(Date:5/12/2017)... 2017  The China and Canada joint ... less water, energy and detergent, and features a powerful disinfection process. ... shoebox-sized washing machine that washes and sanitizes women,s panties or babies, ... ... and does not require an external water inlet. ...
(Date:5/10/2017)... 10, 2017  The Corporate Whistleblower Center says, ... sleep therapy clinics to call us anytime at ... is involved in a substantial scheme to overbill ... from an employee of a medical equipment company ... to provide medical practice groups with extra generous incentives ...
(Date:5/9/2017)... WASHINGTON , May 9, 2017  Demonstrating ... the board of directors for the Pharmaceutical Research ... criteria for membership. Biopharmaceutical companies will now have ... in order to be eligible to join PhRMA. ... criteria, the board is sending a clear message ...
Breaking Medicine Technology: