Navigation Links
Breast Cancer Drug May Also Help Lung Cancer Patients
Date:1/24/2011

By Amanda Gardner
HealthDay Reporter

MONDAY, Jan. 24 (HealthDay News) -- The anti-estrogen drug that transformed the treatment of breast cancer three decades ago may also reduce the risk of dying from lung cancer, researchers say.

In a study published in the Jan. 24 online edition of the journal Cancer, tamoxifen lowered the risk of dying from lung cancer among women who already had breast cancer. However, the results are too preliminary to warrant giving tamoxifen to lung cancer patients.

"There aren't a whole lot of clinical implications, but it does provide more evidence to our accumulating knowledge that female sex hormones are involved in some way, shape or form in lung cancer progression," said Dr. Apar Kishor Ganti, assistant professor of oncology-hematology at the University of Nebraska Medical Center in Omaha. "Whether or not it's a cause is a little sketchy."

Ganti was not involved with the study.

Prior studies had indicated that taking hormone replacement therapy during menopause upped a woman's chances of dying from lung cancer.

So these researchers hypothesized that the opposite might be true -- that anti-estrogens might lower a woman's risk of death from lung cancer.

Previous studies have also indicated that lung cancers, like breast and gynecological cancers, express hormone receptors.

In the current study, Dr. Elisabetta Rapiti, from the Geneva Cancer Registry, and colleagues reviewed records of 6,655 women diagnosed with breast cancer in Switzerland between 1980 and 2003. Just under half (46 percent) received anti-estrogen therapy which, during that time period, was most likely tamoxifen (aromatase inhibitors were not yet in use in Switzerland, the authors stated).

Women taking anti-estrogen therapy had an 87 percent decreased risk of death from lung cancer, compared to women who weren't taking this type of therapy.

There was no link between anti-estrogen therapy and whether or not a woman actually developed lung cancer.

One limitation to the research, Ganti noted, is that only 40 women actually developed lung cancer, so it was a very small study group.

The estrogen receptors implicated in lung cancer "don't seem to discriminate between men and women," Ganti said, indicating that anti-estrogens might have the same effect in men, although it's too early to state this definitively.

Other than breast and gynecological cancers, such as ovarian cancers, lung cancer has been the most extensively studied with regard to its interplay with estrogen, said Jing Peng, a post-doctoral associate in the Cancer Prevention Program at Fox Chase Cancer Center in Philadelphia.

There is limited evidence that estrogen may play a role in head-and-neck cancers as well.

But the issue is a complicated one, with some studies in mice suggesting that tamoxifen might actually promote lung cancer, Peng said.

"This article at least verifies that further studies should be carried out," she said.

More information

The U.S. National Cancer Institute has more on lung cancer.

SOURCES: Apar Kishor Ganti, M.D., assistant professor, oncology-hematology, University of Nebraska Medical Center, Omaha, Neb.; Jing Peng, Ph.D., post-doctoral associate, Cancer Prevention Program, Fox Chase Cancer Center, Philadelphia; Jan. 24, 2011, Cancer, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Breast Cancer Patients With Diabetes May Fare Worse
2. Strong social ties benefit breast cancer patients
3. Breastfeeding -- added protection for cancer survivors?
4. Small Spreads of Breast Cancer May Not Affect Survival
5. U-M researchers find indirect path to attack breast cancer stem cells
6. Scientists identify avoidable breast cancer risk factors
7. Breast Cancer Radiation Before 1984 Tied to Heart Disease
8. Study Finds Racial Disparity in Breast Cancer Outcomes
9. Study provides molecular rationale for combining targeted agents to treat breast cancer
10. Preoperative breast MRI suggests high cancer yield
11. Quality of life measures in breast cancer clinical trials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breast Cancer Drug May Also Help  Lung Cancer Patients
(Date:1/19/2017)... ... January 19, 2017 , ... Sales Focus Inc. (SFI), ... into the US market. , Over the past 20 years SFI has been recognized ... SFI has launched six new clients into the US market. The new clients ...
(Date:1/19/2017)... ... 2017 , ... Each year, the Southeastern Society of Plastic ... of surgeons from over fifteen different countries come together to share and learn ... to breast reconstruction for breast cancer patients, teaching these surgical techniques which ...
(Date:1/18/2017)... ... ... A recent video posting of a new fidget product gathered online momentum as ... stress and anxiety. No one was more surprised than Think Ink Pen founders ... successful Kickstarter campaign raising $67,000 on the popular crowdfunding platform. “We’ve been in ...
(Date:1/18/2017)... ... 18, 2017 , ... Visually learn facts and tips on ... Certain Dri. , Excessive sweating and hyperhidrosis are common conditions that occur in ... explain the seven types of hyperhidrosis. This visual creates awareness about the condition ...
(Date:1/18/2017)... (PRWEB) , ... January 18, ... ... specialty pharmacy industry’s leading journal and most-read publication among specialty pharmacists and ... Medical Center through its Strategic Alliance Partnership (SAP) program, announced Brian Haug, ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , Jan. 18, 2017 The ... Food and Drug Administration (FDA) for its release ... and population health decision makers can proactively share ... products as well as emerging therapies awaiting FDA ... mirrors consensus recommendations that AMCP developed during two ...
(Date:1/18/2017)... 2017  EnteroMedics Inc. (NASDAQ: ETRM ... technology to treat obesity, metabolic diseases and other ... underwritten public offering of units for gross proceeds ... and commissions and offering expenses payable by EnteroMedics. ... A Units, priced at a public offering price ...
(Date:1/18/2017)... PORTLAND, Oregon and PUNE, India ... report published by Allied Market Research, titled, "Breast Imaging Technologies ... projects that the global breast imaging technologies market size was ... reach $4,502 million by 2022, growing at a CAGR of ... and Europe together accounted for ...
Breaking Medicine Technology: