Navigation Links
Breast Cancer Drug May Also Help Lung Cancer Patients
Date:1/24/2011

By Amanda Gardner
HealthDay Reporter

MONDAY, Jan. 24 (HealthDay News) -- The anti-estrogen drug that transformed the treatment of breast cancer three decades ago may also reduce the risk of dying from lung cancer, researchers say.

In a study published in the Jan. 24 online edition of the journal Cancer, tamoxifen lowered the risk of dying from lung cancer among women who already had breast cancer. However, the results are too preliminary to warrant giving tamoxifen to lung cancer patients.

"There aren't a whole lot of clinical implications, but it does provide more evidence to our accumulating knowledge that female sex hormones are involved in some way, shape or form in lung cancer progression," said Dr. Apar Kishor Ganti, assistant professor of oncology-hematology at the University of Nebraska Medical Center in Omaha. "Whether or not it's a cause is a little sketchy."

Ganti was not involved with the study.

Prior studies had indicated that taking hormone replacement therapy during menopause upped a woman's chances of dying from lung cancer.

So these researchers hypothesized that the opposite might be true -- that anti-estrogens might lower a woman's risk of death from lung cancer.

Previous studies have also indicated that lung cancers, like breast and gynecological cancers, express hormone receptors.

In the current study, Dr. Elisabetta Rapiti, from the Geneva Cancer Registry, and colleagues reviewed records of 6,655 women diagnosed with breast cancer in Switzerland between 1980 and 2003. Just under half (46 percent) received anti-estrogen therapy which, during that time period, was most likely tamoxifen (aromatase inhibitors were not yet in use in Switzerland, the authors stated).

Women taking anti-estrogen therapy had an 87 percent decreased risk of death from lung cancer, compared to women who weren't taking this type of therapy.

There was no link between anti-estrogen therapy and whether or not a woman actually developed lung cancer.

One limitation to the research, Ganti noted, is that only 40 women actually developed lung cancer, so it was a very small study group.

The estrogen receptors implicated in lung cancer "don't seem to discriminate between men and women," Ganti said, indicating that anti-estrogens might have the same effect in men, although it's too early to state this definitively.

Other than breast and gynecological cancers, such as ovarian cancers, lung cancer has been the most extensively studied with regard to its interplay with estrogen, said Jing Peng, a post-doctoral associate in the Cancer Prevention Program at Fox Chase Cancer Center in Philadelphia.

There is limited evidence that estrogen may play a role in head-and-neck cancers as well.

But the issue is a complicated one, with some studies in mice suggesting that tamoxifen might actually promote lung cancer, Peng said.

"This article at least verifies that further studies should be carried out," she said.

More information

The U.S. National Cancer Institute has more on lung cancer.

SOURCES: Apar Kishor Ganti, M.D., assistant professor, oncology-hematology, University of Nebraska Medical Center, Omaha, Neb.; Jing Peng, Ph.D., post-doctoral associate, Cancer Prevention Program, Fox Chase Cancer Center, Philadelphia; Jan. 24, 2011, Cancer, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Breast Cancer Patients With Diabetes May Fare Worse
2. Strong social ties benefit breast cancer patients
3. Breastfeeding -- added protection for cancer survivors?
4. Small Spreads of Breast Cancer May Not Affect Survival
5. U-M researchers find indirect path to attack breast cancer stem cells
6. Scientists identify avoidable breast cancer risk factors
7. Breast Cancer Radiation Before 1984 Tied to Heart Disease
8. Study Finds Racial Disparity in Breast Cancer Outcomes
9. Study provides molecular rationale for combining targeted agents to treat breast cancer
10. Preoperative breast MRI suggests high cancer yield
11. Quality of life measures in breast cancer clinical trials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breast Cancer Drug May Also Help  Lung Cancer Patients
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... The ... Project offering a new model of care for living and healing, celebrated its ... values: Meaningful Life in a Real Home provided by Empowered Staff. , “This is ...
(Date:5/26/2016)... ... May 26, 2016 , ... MadgeTech will be showcasing its line ... in Warner, New Hampshire at the MadgeTech headquarters. With products sold in more than ... by government agencies, including NASA. , In 2012, NASA strategically set up 17 ...
(Date:5/26/2016)... ... May 26, 2016 , ... An April Gallup survey found rising ... 550 employees of Sun Health Senior Living (SHSL) may not share those ... doctor and prescription copays for the year, while holding the line on increasing their ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... supply chain solutions, today announced the organization has earned its ISO 13485 certification, ... and is compliant with all rules and policies associated with ISO quality standard ...
(Date:5/26/2016)... Texas (PRWEB) , ... May 26, 2016 , ... ... Friday, May 13 at Blackhorse Golf Club in Cypress. With the help of community ... non-profit that restores, empowers, and renews hope for wounded service members and their families ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 According ... Share, Development, Growth and Demand Forecast to 2022 - ... Pump and Others)" published by P&S Market Research, the ... million in 2015, and it is expected to grow ... type, the insulin pump segment is expected to witness ...
(Date:5/25/2016)... , May 25, 2016 MedDay, ... disorders, announces that an oral presentation entitled "High doses of ... MS-SPI trial" will be given by Professor Ayman Tourbah ... 2nd Congress of the European Academy of Neurology (EAN) in ... and related disorders 3" will take place on Sunday, 29 ...
(Date:5/24/2016)... 24, 2016 Cirujanos holandeses han ... a los médicos a compartir sus mejores prácticas por ... mundial. Profesionales médicos de Europa, África, Asia ... a la aplicación, que combina la transmisión en vivo ... seguro. Educación   "Imagine un médico ...
Breaking Medicine Technology: