Navigation Links
Breast Cancer Drug May Also Help Lung Cancer Patients
Date:1/24/2011

By Amanda Gardner
HealthDay Reporter

MONDAY, Jan. 24 (HealthDay News) -- The anti-estrogen drug that transformed the treatment of breast cancer three decades ago may also reduce the risk of dying from lung cancer, researchers say.

In a study published in the Jan. 24 online edition of the journal Cancer, tamoxifen lowered the risk of dying from lung cancer among women who already had breast cancer. However, the results are too preliminary to warrant giving tamoxifen to lung cancer patients.

"There aren't a whole lot of clinical implications, but it does provide more evidence to our accumulating knowledge that female sex hormones are involved in some way, shape or form in lung cancer progression," said Dr. Apar Kishor Ganti, assistant professor of oncology-hematology at the University of Nebraska Medical Center in Omaha. "Whether or not it's a cause is a little sketchy."

Ganti was not involved with the study.

Prior studies had indicated that taking hormone replacement therapy during menopause upped a woman's chances of dying from lung cancer.

So these researchers hypothesized that the opposite might be true -- that anti-estrogens might lower a woman's risk of death from lung cancer.

Previous studies have also indicated that lung cancers, like breast and gynecological cancers, express hormone receptors.

In the current study, Dr. Elisabetta Rapiti, from the Geneva Cancer Registry, and colleagues reviewed records of 6,655 women diagnosed with breast cancer in Switzerland between 1980 and 2003. Just under half (46 percent) received anti-estrogen therapy which, during that time period, was most likely tamoxifen (aromatase inhibitors were not yet in use in Switzerland, the authors stated).

Women taking anti-estrogen therapy had an 87 percent decreased risk of death from lung cancer, compared to women who weren't taking this type of therapy.

There was no link between anti-estrogen therapy and whether or not a woman actually developed lung cancer.

One limitation to the research, Ganti noted, is that only 40 women actually developed lung cancer, so it was a very small study group.

The estrogen receptors implicated in lung cancer "don't seem to discriminate between men and women," Ganti said, indicating that anti-estrogens might have the same effect in men, although it's too early to state this definitively.

Other than breast and gynecological cancers, such as ovarian cancers, lung cancer has been the most extensively studied with regard to its interplay with estrogen, said Jing Peng, a post-doctoral associate in the Cancer Prevention Program at Fox Chase Cancer Center in Philadelphia.

There is limited evidence that estrogen may play a role in head-and-neck cancers as well.

But the issue is a complicated one, with some studies in mice suggesting that tamoxifen might actually promote lung cancer, Peng said.

"This article at least verifies that further studies should be carried out," she said.

More information

The U.S. National Cancer Institute has more on lung cancer.

SOURCES: Apar Kishor Ganti, M.D., assistant professor, oncology-hematology, University of Nebraska Medical Center, Omaha, Neb.; Jing Peng, Ph.D., post-doctoral associate, Cancer Prevention Program, Fox Chase Cancer Center, Philadelphia; Jan. 24, 2011, Cancer, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Breast Cancer Patients With Diabetes May Fare Worse
2. Strong social ties benefit breast cancer patients
3. Breastfeeding -- added protection for cancer survivors?
4. Small Spreads of Breast Cancer May Not Affect Survival
5. U-M researchers find indirect path to attack breast cancer stem cells
6. Scientists identify avoidable breast cancer risk factors
7. Breast Cancer Radiation Before 1984 Tied to Heart Disease
8. Study Finds Racial Disparity in Breast Cancer Outcomes
9. Study provides molecular rationale for combining targeted agents to treat breast cancer
10. Preoperative breast MRI suggests high cancer yield
11. Quality of life measures in breast cancer clinical trials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breast Cancer Drug May Also Help  Lung Cancer Patients
(Date:9/18/2017)... ... September 18, 2017 , ... Cosmetic Town, an online ... According to the senior editor of Cosmetic Tow, “Our forum section is an interactive, ... provide answers to other forum members thinking about having cosmetic surgery. The interaction and ...
(Date:9/18/2017)... ... September 18, 2017 , ... Aegis Therapies, a national leader ... executive team adding a Chief Financial Officer following their announcement on January 1, ... support the strategic growth strategy Aegis has defined for the next several years. ...
(Date:9/18/2017)... ... , ... In the age of digital media, limiting screen time among infants ... and a convenient way to soothe fussy children. , According to a recent study, ... sensory development toys completely. , The study, entitled “Is handheld screen time use associated ...
(Date:9/18/2017)... ... September 18, 2017 , ... While Floridians confront the aftermath ... based company, has launched an aid effort focused on the elderly population that was ... over two days and left thousands homeless and displaced. , “The elderly are often ...
(Date:9/18/2017)... ... September 18, 2017 , ... Dallas and Plano Pet Sitting ... Services . The asset-based purchase combines two of the best reviewed and highly ... Park Cities Pet Sitter, says that it was clear from the outset that acquiring ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... INDIANAPOLIS , Sept. 7, 2017  Eli ... today announced actions to streamline operations to more ... to improve its cost structure. Global workforce reductions, ... program, are expected to impact approximately 3,500 positions. ... the company expects annualized savings of approximately $500 ...
(Date:9/7/2017)... 2017   BioLife Solutions , Inc. (NASDAQ: ... clinical grade cell and tissue hypothermic storage and ... Rice , President and CEO, will be presenting at two ... & Renshaw 19 th Annual Global Investment Conference on ... Pacific time). The conference is being held at the New ...
(Date:9/6/2017)... 6, 2017 Eli Lilly and Company (NYSE: ... new data for galcanezumab and lasmiditan, two investigational treatments ... Headache Society (IHC) taking place Sept. 7-10 in ... highlight new, long-term data from an open-label study evaluating ... (120 mg and 240 mg) for the prevention of ...
Breaking Medicine Technology: