Navigation Links
Breakthrough offers first direct measurement of spinal cord myelin in multiple sclerosis
Date:9/23/2013

Researchers have made an exciting breakthrough developing a first-of-its-kind imaging tool to examine myelin damage in multiple sclerosis (MS). An extremely difficult disease to diagnose, the tool will help physicians diagnose patients earlier, monitor the disease's progression, and evaluate therapy efficacy.

Case Western Reserve University School of Medicine scientists have developed a novel molecular probe detectable by positron emission tomography (PET) imaging. The new molecular marker, MeDAS, offers the first non-invasive visualization of myelin integrity of the entire spinal cord at the same time, as published today in an article in the Annals of Neurology.

"While MS originates in the immune system, the damage occurs to the myelin structure of the central nervous system. Our discovery brings new hope to clinicians who may be able to make an accurate diagnosis and prognosis in as little as a few hours compared to months or even years," said Yanming Wang, PhD, senior author of study and associate professor of radiology at Case Western Reserve University School of Medicine. "Because of its shape and size, it is particularly difficult to directly detect myelin damage in the spinal cord; this is the first time we have been able to image its function at the molecular level."

As the most common acquired autoimmune disease currently affecting more than two million people worldwide, MS is characterized by destruction of myelin, the membrane that protects nerves. Once damaged, it inhibits the nerves' ability to transmit electrical impulses, causing cognitive impairment and mobility dysfunction. So far, there is no cure for MS, therapies are only available that modify the symptoms.

In addition to its role in monitoring the effects of myelin-repair drugs currently under development, the new imaging tool offers a real-time quantitative clinical diagnosis of MS. A long lag exists between the onset of disease, physical symptoms in the patient and diagnosis via behavioral testing and magnetic resonance imaging (MRI). The lesions, or plaques, as detected by a MRI in the brain and spinal cord are not myelin specific and thus poorly associated with a patient's disease severity or progression. There is an urgent need to find a new imaging marker that correlates with a patient's pathology.

"This discovery has open the door to develop new drugs that can truly restore nerve function, not just modify the symptoms," said Robert Miller, PhD, co-author on the study, vice president for research for Case Western Reserve and the Allen C. Holmes Professor of Neurological Diseases at the School of Medicine. "A cure for MS requires both repairing myelin and a tool to measure the mechanism."

For the past 20 years, Miller's lab has been working tirelessly to create new myelin-repair therapies that would restore nerve function. Successful translation of new drugs from animal studies to human clinical trials is contingent upon researchers' ability to measure and evaluate the effectiveness of a therapy.

Created by Wang's laboratory, the MeDAS molecular probe works like a homing device. Injected into the body intravenously, it is programmed to seek out and bind only to myelin in the central nervous system, i.e., the brain, spinal cord and optic nerves. A positron-emitting radioisotope label on the molecule allows a PET scanner to detect the targets and quantify their intensity and location. The data can then be reconstructed into an image as shown in the article: http://onlinelibrary.wiley.com/doi/10.1002/ana.23965/abstract.

"This is an indispensable tool to help find a new way to treat MS down the road" said Chunying Wu, PhD, first author of the study and instructor of radiology at Case Western Reserve. "It can also be used as a platform technology to unlock the mysteries of other myelin related diseases such as spinal cord injury."


'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Related medicine news :

1. Voices Against Brain Cancer Discusses Possible Breakthrough in Brain Cancer Treatment
2. SafeToSleep Expands International Distribution of Breakthrough Sleep and Breathing Baby Monitor
3. Lipo Body Sculpture of Houston Announces Breakthrough Treatment for Non-Surgical Neck Tightening
4. The Health Briefs TV Show Airs Segment on Breakthrough Therapies
5. Breakthrough model holds promise for treating Graves disease
6. Medical Researchers Say They Have Made a Breakthrough That Could Lead to a Potential Cure for AIDS
7. Golf Putting Tips
8. How “Breakthrough Putting Secrets” Helps People Become Professional Golfers – Vinamy
9. Putting Tips
10. How “Breakthrough Putting Secrets” Helps People Play Golf Professionally –V-kool
11. RantNetwork Introduces Breakthrough Translation and Interpretation App for the Mobile Communication Market
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2016)... ... , ... Are You Concerned About Mold In Your Home or Workplace? ... Companies in VA, MD and DC, recently completed its application for the new District ... in the district of Columbia is a good thing stated John Taylor, Owner of ...
(Date:12/2/2016)... ... , ... On Dec. 2, 2016, CURE® magazine will host the 4th Annual ... MPN Heroes—eight individuals who have made a difference in the field of rare blood ... care, demonstrating leadership within the MPN community and/or a commitment to individual patients. , ...
(Date:12/2/2016)... ... December 02, 2016 , ... Center for Autism and Related Disorders (CARD) ... by autism spectrum disorder (ASD) and other developmental disabilities. The group, which is being ... and other caregivers the opportunity to share stories and advice, seek help, and continue ...
(Date:12/2/2016)... Beverly Hills, CA (PRWEB) , ... December 02, ... ... and reconstructive surgeon in Beverly Hills, California, will be included in the 2016 ... is given to exceptional professionals based on the amalgamation of their education, experience, ...
(Date:12/2/2016)... OH (PRWEB) , ... December 02, 2016 , ... ... of veterinarian diagnostic imaging systems and the first company to offer ... With a Heart at their tradeshow booth # 941 for the American Association ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... bioLytical Laboratories, ein Weltführer bei schnellen Tests für Infektionskrankheiten, hat sein ... eingeführt. Continue Reading ... ... , ... ) bioLytical wurde durch die Clinton Health Access ...
(Date:12/2/2016)... 2016   CytoSorbents Corporation (NASDAQ: CTSO ... Union approved CytoSorb ® cytokine adsorber to treat ... announced that Dr. Phillip Chan , Chief Executive ... Micro Main Event investor conference held from December ... Sunset Boulevard Hotel in Los Angeles, California ...
(Date:12/2/2016)... , Dec. 1, 2016  Today, Simpson Healthcare ... the honor of being selected as winners of multiple ... Healthcare Executives Website at the PLATINUM level, Blue Zones ... Module at the GOLD Level, and our proprietary 3ConneX ... At Simpson Healthcare Executives, we are excited to showcase ...
Breaking Medicine Technology: