Navigation Links
Breakthrough news involving migraine
Date:8/31/2010

Investigators from the International Headache Genetics Consortium, a world-wide collaboration of researchers, have identified the first-ever genetic risk factor associated with common types of migraine. Researchers looked at genetic data of more than 50,000 people and found new insights into the triggers for migraines attacks, which commonly begin in puberty and but tend to affect people aged between 20 to 45 years of age. Migraine affects approximately one in six women and one in 12 men.

"This is a major stride in migraine science," said David W. Dodick, president of the American Headache Society, and professor of neurology at the Mayo Clinic College of Medicine, and the director of the Headache Program in Phoenix, Arizona. Underscoring the significance of the findings, Dr. Dodick said, "It is the first study to identify a genetic risk factor for the common subtypes of migraine, and provides some support for the general concept of migraine as a state of brain hyperexcitability. It also supports previous research findings on the potential role of glutamate in migraine , as well novel glutamate modulating drugs that are currently being tested in migraine. Further work may provide insight into the precise molecular mechanism(s) of migraine as well as future targets for novel therapies."

The team found that patients with a particular DNA variant on Chromosome 8 between two genes -- PGCP and MTDH/AEG-1 -- have a significantly greater risk for developing migraine. It appears that the associated DNA variant regulates levels of glutamate -- a chemical, known as a neurotransmitter, which transports messages between nerve cells in the brain. Prevention of the build up of glutamate at the synapse (space between nerve endings) may provide a promising target for novel therapeutics to ease the burden of the disease, according to Dr. Dodick. Although researchers have in the past described genetic mutations giving rise to rare and extreme forms of migraine, this is the first time a team has identified a genetic variant giving rise to the common forms of the condition.


'/>"/>

Contact: Martha Cid
marthac@mbooth.com
212-539-3258
American Headache Society
Source:Eurekalert

Related medicine news :

1. Human Dental Technology Leads to Breakthroughs for Pet Dental Health at Sergeants Pet Care Products, Inc.
2. First Breakthrough in Water Heating Technology!
3. New DNA technique leads to a breakthrough in child cancer research
4. Northern Illinois Proton Center on the Verge of Major Medical Breakthrough
5. OvaCue Fertility Monitor Breakthrough Allows Women to See Fertility Color-coded on a Calendar Over Time
6. National Event Addresses Breakthroughs in Crohn's & Colitis Research: National Expert & Researcher Answers Key Questions on Interactive Webcast/Teleconference
7. Breakthroughs in treatment of spine and back conditions
8. buySAFE, Inc. Releases a Breakthrough White Paper that is a Must Read for Every Internet Retailer Interested in Increasing Website Conversion
9. Tampa Bay Vein Treatment and Cosmetic Dermatology Practice Using New Laser Technology Some Say is the Latest Breakthrough
10. Breakthrough for babies born with severe cleft palates after experiments at ISIS
11. Gene-Targeted Cancer Fix Could Be a Breakthrough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... ... serving communities in the greater Dallas, Miami, and Raleigh regions, is organizing an ... to overcome a rare and deadly chromosome abnormality. , After struggling since birth ...
(Date:10/13/2017)... ... , ... As health professionals work to improve their approach to healthcare, there ... more than filling out a survey; in many cases health professionals and patients are ... care and research on the importance of active engagement with patients and members of ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family Medicine's (ABFM) ... and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton ... until Dr. Puffer’s retirement at the end of 2018. Upon assuming the role of ...
(Date:10/13/2017)... ... 2017 , ... PurhealthRX , a leading Health and Nutrition Company, is ... to full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing ... easily incorporated into liquid products, while reducing costs to end users. , The team ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & Associates ... special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to date ... elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded by ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... -- Halo Labs announces the European launch of their new low ... MIBio 2017 in Cambridge, U.K on October ... biopharmaceutical samples with unprecedented speed and sensitivity while using far less ... Imaging. ... analysis system ...
(Date:9/27/2017)... , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading ... announced that its MyDario product is expected to appear on The Dr. ... The Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show ... The segment ...
(Date:9/22/2017)... AVACEN Medical (AVACEN) announced that its CE-Marked ... those with the widespread pain associated with fibromyalgia in ... Essex, England commented, "I had ... no sleep at all, tremendous pain, with every movement ... [the AVACEN 100] enough, how this has and is ...
Breaking Medicine Technology: