Navigation Links
Breakthrough news involving migraine
Date:8/31/2010

Investigators from the International Headache Genetics Consortium, a world-wide collaboration of researchers, have identified the first-ever genetic risk factor associated with common types of migraine. Researchers looked at genetic data of more than 50,000 people and found new insights into the triggers for migraines attacks, which commonly begin in puberty and but tend to affect people aged between 20 to 45 years of age. Migraine affects approximately one in six women and one in 12 men.

"This is a major stride in migraine science," said David W. Dodick, president of the American Headache Society, and professor of neurology at the Mayo Clinic College of Medicine, and the director of the Headache Program in Phoenix, Arizona. Underscoring the significance of the findings, Dr. Dodick said, "It is the first study to identify a genetic risk factor for the common subtypes of migraine, and provides some support for the general concept of migraine as a state of brain hyperexcitability. It also supports previous research findings on the potential role of glutamate in migraine , as well novel glutamate modulating drugs that are currently being tested in migraine. Further work may provide insight into the precise molecular mechanism(s) of migraine as well as future targets for novel therapies."

The team found that patients with a particular DNA variant on Chromosome 8 between two genes -- PGCP and MTDH/AEG-1 -- have a significantly greater risk for developing migraine. It appears that the associated DNA variant regulates levels of glutamate -- a chemical, known as a neurotransmitter, which transports messages between nerve cells in the brain. Prevention of the build up of glutamate at the synapse (space between nerve endings) may provide a promising target for novel therapeutics to ease the burden of the disease, according to Dr. Dodick. Although researchers have in the past described genetic mutations giving rise to rare and extreme forms of migraine, this is the first time a team has identified a genetic variant giving rise to the common forms of the condition.


'/>"/>

Contact: Martha Cid
marthac@mbooth.com
212-539-3258
American Headache Society
Source:Eurekalert

Related medicine news :

1. Human Dental Technology Leads to Breakthroughs for Pet Dental Health at Sergeants Pet Care Products, Inc.
2. First Breakthrough in Water Heating Technology!
3. New DNA technique leads to a breakthrough in child cancer research
4. Northern Illinois Proton Center on the Verge of Major Medical Breakthrough
5. OvaCue Fertility Monitor Breakthrough Allows Women to See Fertility Color-coded on a Calendar Over Time
6. National Event Addresses Breakthroughs in Crohn's & Colitis Research: National Expert & Researcher Answers Key Questions on Interactive Webcast/Teleconference
7. Breakthroughs in treatment of spine and back conditions
8. buySAFE, Inc. Releases a Breakthrough White Paper that is a Must Read for Every Internet Retailer Interested in Increasing Website Conversion
9. Tampa Bay Vein Treatment and Cosmetic Dermatology Practice Using New Laser Technology Some Say is the Latest Breakthrough
10. Breakthrough for babies born with severe cleft palates after experiments at ISIS
11. Gene-Targeted Cancer Fix Could Be a Breakthrough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Dublin, CA (PRWEB) , ... June 27, 2016 ... ... Community College District , the only authorized OSHA Training Institute Education Center headquartered ... illness by protecting their workers from extreme heat at their worksites. Employers ...
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media ... Pro X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice ... X users can now reveal the media of their split screens with growing ...
(Date:6/27/2016)... ... , ... TherapySites, the leading website and online ... Counseling Association. This new relationship allows TherapySites to continue to extend their ... benefits and promotional offers. , "TCA is extremely excited about this new partnership, ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... today announced its strategic partnership with Connance, a healthcare industry leader providing ... companies’ proven, proprietary technology combine to provide health systems, hospitals and ambulatory ...
(Date:6/27/2016)... NY (PRWEB) , ... June 27, 2016 , ... ... using cutting edge technology to revolutionize the emergency ambulance transport experience for the ... are aware of how Uber has disrupted the taxi industry through the use ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 26, 2016 One of Australia,s ... formation of a new biotechnology company, Noxopharm Limited [ABN 50 608 ... IPO and to list on the ASX. Noxopharm is ... to enter a Phase 1 clinical study later this year. ... one of the biggest problems facing cancer patients - the ability ...
(Date:6/26/2016)... 2016 Jazz Pharmaceuticals plc (Nasdaq: ... Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ("HSR"), ... Inc. ("Celator"; Nasdaq: CPXX ) expired effective ... As previously announced on May 31, 2016, ... agreement under which Jazz Pharmaceuticals has commenced a tender ...
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
Breaking Medicine Technology: