Navigation Links
Breakthrough model holds promise for treating Graves' disease

Chevy Chase, MDResearchers have developed the first animal model simulating the eye complications associated with the thyroid condition Graves' disease, a breakthrough that could pave the way for better treatments, according to a recent study accepted for publication in The Endocrine Society's journal Endocrinology.

Graves' disease is an autoimmune disorder that causes the body to produce antibodies that attack the thyroid gland. The condition causes the thyroid gland to become overactive and produce too much thyroid hormone. If left untreated, it can lead to heart failure or osteoporosis.

Graves' disease is most common in women. About 1 percent of Caucasian women have autoimmune thyroid disease where the thyroid is either over- or underactive. Among those who have Graves' disease, more than half develop eye complications, according to the study's lead author, J. Paul Banga, PhD, of King's College London School of Medicine in the United Kingdom. These complications include Graves' orbitopathy, where swelling of tissue behind the eyes causes them to bulge outward. The condition can cause pain and lead to blindness.

"Current treatment options for eye complications associated with Graves' disease are limited," Banga said. "Better treatments are needed for Graves' orbitopathy to reduce the risks of permanent disfigurement and social stigma. Having an animal model to test preventative treatments could lead to important advances that will ultimately benefit people with Graves' disease."

The condition is currently treated with steroids, which can cause undesirable side effects such as weight gain and osteoporosis.

Although researchers have developed animal models of Graves' disease in the past, these models were challenging to replicate and none were able to simulate the eye problems seen in people with Graves' disease.

To develop the new model, researchers injected mice with small circular, double-stranded DNA molecules called plasmids. Over the course of three months, scientists used electronic pulses to ensure the DNA molecules were absorbed into the cells of each mouse. Mice that underwent this procedure developed eye problems like those seen in human patients who have Graves' disease, while the control group of mice did not develop these complications.

"The new animal model opens the door for scientists to conduct needed mechanistic studies and identify preventative therapies to minimize this painful and debilitating condition," Banga said.


Contact: Jenni Glenn Gingery
The Endocrine Society

Related medicine news :

1. Medical Researchers Say They Have Made a Breakthrough That Could Lead to a Potential Cure for AIDS
2. Golf Putting Tips
3. How “Breakthrough Putting Secrets” Helps People Become Professional Golfers – Vinamy
4. Putting Tips
5. How “Breakthrough Putting Secrets” Helps People Play Golf Professionally –V-kool
6. RantNetwork Introduces Breakthrough Translation and Interpretation App for the Mobile Communication Market
7. Xtreme No - Breakthrough Nitric Oxide Product Makes Muscle Building Faster and Easier; Now Available With One Month Extra Supply
8. Successful Fitness Expert and Business Coach, Bedros Keuilian, Gives Insight on How to Market a Personal Training Business with Fitness Business Breakthrough
9. Statement from the Sensory Processing Disorder Foundation Endorsing New Breakthrough Study Revealing Biological Basis for Sensory Processing Disorders in Kids
10. Medical Breakthrough from Mercy Research & Development Can Protect Wounded Warriors' Sight and Help Everyday Americans
11. Acai Berry Select - Most Exciting Breakthrough in Today's Weight Loss World Now Comes with One Month Extra Supply
Post Your Comments:
(Date:10/13/2017)... PITTSBURGH, Pa. (PRWEB) , ... October 13, 2017 , ... ... the dark poses a problem. Fortunately, an inventor from Austin, Texas, has identified a ... access to medication in darkness or restricted lighting. As such, it eliminates the need ...
(Date:10/13/2017)... Pekin, IL (PRWEB) , ... October 13, 2017 ... ... Foundation, which established the certification process to promote standards of excellence for the ... iaedp™ Symposium, scheduled for March 22 – 25, 2018 in Orlando, Florida at ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical ... the primary prevention of cardiovascular diseases during the 15th Annual Women’s Health ...
(Date:10/13/2017)... ... , ... Apple Rehab Shelton Lakes , which specializes in the delivery ... as part of a disaster drill on October 3rd. , Apple Rehab participated with ... Manager, as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). ...
(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... IRVING, Texas , Oct. 11, 2017  Caris ... science focused on fulfilling the promise of precision medicine, ... Institute has joined Caris, Precision Oncology Alliance™ (POA) as ... leading cancer centers, the St. Jude Crosson Cancer Institute ... to advance the use of tumor profiling, making cancer ...
(Date:10/10/2017)... 10, 2017  NDS received FDA 510(k) clearance in May 2017 ... display stand specifically designed for endoscopy environments. An innovative secondary monitor ... clinical solution to support the improvement of patient outcomes, procedural efficiency, ... ... ...
(Date:10/5/2017)... , Oct. 5, 2017  In response ... of Oral and Maxillofacial Surgeons (AAOMS) released prescribing ... – to be used as a first-line therapy ... Recognizing the ... AAOMS White Paper "Opioid Prescribing: Acute and Postoperative ...
Breaking Medicine Technology: