Navigation Links
Breakthrough model for human cancer may improve development of cancer drugs; study in PNAS
Date:4/6/2009

ly Herceptin. This represents a big step forward in developing xenograft models that will accurately predict patient responses to agents that are in preclinical development. The HIM model is an exciting, experimentally tractable human in vivo system that holds great potential for advancing our basic understanding of cancer biology and for the discovery and testing of targeted therapies."

By employing a tissue recombinant system and a gene transduction system, researchers assessed the in vivo biological consequences of specific genetic alterations in the reconstituted breast tissue. Introduction of different combinations of oncogenes, such as HER2, KRAS, PI3 kinase and p53, into the tissue enabled the researchers to dissect the contribution of each gene to human tumor formation in the model.

The authors also demonstrated the utility of the HIM models for drug efficacy testing by treating the HER2 driven breast tumors with different HER2 antagonists. The resulting potent inhibition of HIM tumor growth correlates with what has been observed in the clinic.

"With the increasing knowledge of specific genetic alterations in breast cancer, there is now a significant opportunity to correlate activity of anticancer agents with specific genetic alterations in tumors," added Murray O. Robinson, Ph.D., senior vice president, oncology at AVEO. "Our proprietary models provide a defined genetic context in which to validate cancer gene candidates, determine their biological roles in various stages of cancer progression and test targeted therapies. We have been very encouraged by the similarity to human patients in response to widely used breast cancer agents."


'/>"/>

Contact: Caton Lovett
caton@purecommunicationsinc.com
910-232-7166
Pure Communications Inc.
Source:Eurekalert

Page: 1 2

Related medicine news :

1. On 30th Anniversary, Angioplasty Celebrated as Modern Medical Breakthrough in Stopping Heart Attack
2. drugstore.com and Revolution Health Group Announce Breakthrough Deal
3. New Round of Lupus Research Institute Awards Brings Promise of More Breakthroughs
4. CBaySystems Introduces CBayPraxis - A Breakthrough Solution Focused on Physician Practice Efficiency
5. Oosight Imaging System Enables a Breakthrough: The Viable Transfer of Genetic Material for Stem Cell Nuclear Reprogramming in Primates
6. Breakthrough in organ rejection diagnosis examines gene behavior
7. Safe Sex Passport Launches to Provide Breakthrough Protection Against STDs and HIV
8. Major breakthrough toward the treatment of HIV/HAART-associated Lipodystrophy Syndrome
9. Cardica Announces Live Webcast Demonstrating Breakthrough Device to Facilitate Beating Heart and Robotic Coronary Revascularization Surgery
10. TIME Magazine Names GeneSearch(TM) One of the Top 10 Medical Breakthroughs in 2007
11. California Breakthrough a Pivotal Moment in Fight to Transform Nations Health Care System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... ... 2015 Phil Valentine – the Executive Director of Connecticut Community for Addiction Recovery (CCAR) – ... Mountain and heading north. Since that day, Phil has hiked over 1400 miles in nine ... and family. He visited CCAR and left an inspirational message to his staff: “You ...
(Date:7/31/2015)... ... ... Down is a reputable source of authentic tickets for the 2015 iHeart Radio Music ... genre of music will have an act they are excited to see at this two-day ... artists will perform: Sam Smith, Coldplay, Kenny Chesney, The Who, Jason Derulo, Demi Lovato, ...
(Date:7/31/2015)... ... August 01, 2015 , ... The Honor Society of Nursing, ... on the Future of Nursing (GAPFON) 20-21 July 2015 in San Juan, Puerto Rico. ... this meeting. , Dr. Silvia Cassiani, Advisor, Nursing and Allied Health Personnel Development, Unit ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a ... going on in Chicago at Grant Park. The festival will end on Sunday, ... America to Chicago for the annual Lollapalooza. This unique and unbelievably popular festival ...
(Date:7/31/2015)... ... July 31, 2015 , ... Recently touted by ... predictive health analytics , Jvion continues to disrupt the predictive analytic and ... that targets patient and population level illness to drive prevention and better health ...
Breaking Medicine News(10 mins):Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2
... A study by the computational neuroscientist of Vanderbilt University ... an insight into neural circuits that play a role ... that make us apply previously learned rules on new ... feel that the new use of technology in understanding ...
... the grapefruit seeds contain antioxidants that help to ... had been associated with acidity and gastrointestinal irritation, ... that have healing properties. Researchers from Poland, who ... study findings at the Digestive Disease Week meeting, ...
... cancer after undergoing surgery can reduce the risk of recurrence// ... presented at the annual meeting of American Society of Clinical ... 50% for the patients who took regular aspirin after surgery, ... ,Colon and rectum together form the colorectal area. That is ...
... for people whose blood pressure do not lower //during night ... a healthy normal person blood pressure tends to lower while ... disturbances may elevate the nighttime blood pressures. ,The ... of blood pressure at night may be the predictor for ...
... out that certain ordinary drugs like//anti-psychotic and gastro-intestinal drugs ... study, which was published in the European Heart Journal, ... activity controlling heartbeats that can increase the risk of ... can prolong the duration of electrical activity that controls ...
... or nocturnal gastro esophageal reflux may be due// to ... ,Nocturnal heartburns often lead to disturbed sleep and excessive ... other disease. Nocturnal gastro esophageal reflux or heartburn is ... disease. ,Researchers of University of Arizona College ...
Cached Medicine News:
(Date:7/30/2015)... 2015  Tandem Diabetes Care®, Inc. (NASDAQ: ... of the t:slim® and t:flex™ Insulin Pumps, today ... Agreements with Dexcom, Inc. to allow the integration ... Dexcom G5 and G6 continuous glucose monitoring ("CGM") ... platform with Dexcom,s future CGM systems is an ...
(Date:7/30/2015)... N.J. , July 30, 2015  Unichem Pharmaceuticals ... recalling one lot of Hydrochlorothiazide tablets 25 mg 1000-count ... initiated as a precautionary measure due to the identification ... the product. The risk associated with ... tablet is the increased probability of experiencing Clopidogrel,s side ...
(Date:7/30/2015)... PTC Therapeutics, Inc. (NASDAQ: PTCT ) ... for the second quarter ending June 30, 2015. ... the organization.  We are excited to be near the ... ever conducted with topline results expected in the fourth ... PTC Therapeutics, Inc. "Translarna is now commercially available in ...
Breaking Medicine Technology:Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 3Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 2PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 3PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 4PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 5PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 6PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 7PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 8PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 9PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 10
... MYL ) today announced that its subsidiary Matrix Laboratories ... Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) ... mg, the generic version of Pfizer,s Neurontin ® Capsules ... Gabapentin Capsules had U.S. sales of approximately $300 million ...
... 2011 PAREXEL International Corporation (Nasdaq: ... the Raymond James Investors Conference in Orlando, FL.  James Winschel, ... a presentation on PAREXEL at 2:50 p.m.  ET on Monday, ... presentation will be available through the "Investors" section ...
Cached Medicine Technology:PAREXEL International to Present at Raymond James Investors Conference 2
The Vision Premier software features advanced,capabilities, including automatic categorization,of beats, tachogram review and full-disclosure,viewing, providing the tools needed for even,the ...
The Deltec Cozmo® insulin pump is small, about the size of a cell phone, and only weighs 3.3 ounces (w/ battery and full cartridge). Its ergonomic design fits comfortably in the palm of your han...
The IR 1000 Insulin Infusion Pump from Animas offers unprecedented safety features, performance, and convenience....
... was designed specifically to meet the varying needs ... a simple to use, compact, dual application system ... field of light based hair removal. SpaTouch works ... safe for use on nearly all face and ...
Medicine Products: