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Breakthrough method predicts risk of invasive breast cancer
Date:4/28/2010

For the first time, scientists have discovered a way to predict whether women with ductal carcinoma in situ (DCIS) the most common form of non-invasive breast cancer are at risk of developing more invasive tumors in later years.

As a result of the finding, women with DCIS will have the opportunity to be more selective about their treatment, according to the scientists.

"Women will have much more information, so they can better know their risk of developing invasive cancer,'' said lead author Karla Kerlikowske, MD. "It will lead to a more personalized approach to treatment. As many as 44 percent of patients with DCIS may not require any further treatment, and can rely instead on surveillance.''

The study was led by researchers at the University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, and is reported online by the "Journal of the National Cancer Institute.''

The authors followed the medical histories of 1,162 women aged 40 years and older who were diagnosed with DCIS and treated with lumpectomy. They found that two factors were predictors of risk of developing invasive cancer within eight years after a diagnosis of DCIS: the method by which it was detected and expression of several biomarkers. Findings showed that a breast lump that is diagnosed as DCIS was more predictive of a high risk of subsequent invasive cancer than DCIS diagnosis by mammography.

The study also found that different combinations of biomarkers measured on the initial DCIS tissue were associated with varying levels of risk of invasive cancer or DCIS. These biomarkers include estrogen receptor, progesterone receptor, Ki67 antigen, p53, p16, epidermal growth factor receptor-2, and cyclooxygenase-2. Women who express high levels of p16, cyclooxygenase-2 and Ki67 were more likely to develop invasive cancer after their initial DCIS diagnosis.

Because of the research, physicians will now be ab
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Contact: Elizabeth Fernandez
EFernandez@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

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