Navigation Links
Breakthrough in pre-eclampsia test
Date:2/12/2008

A team at the University of Leeds has discovered a way of diagnosing pre-eclampsia, a condition which affects almost one in ten pregnant women and accounts for up to 15% of all premature deliveries.

They now plan to develop a user-friendly diagnostic kit within five years which could be used in hospitals all over the world to safely and speedily test all pregnant women. The potential saving of a predictor for the NHS alone has been estimated at up to 500m a year with the reduction in medical care required for the mother and her baby.

The team has been able to distinguish between pregnant women who are healthy and those with pre-eclampsia by studying samples of their blood plasma taken at the same time as routine blood samples.

The symptoms of pre-eclampsia include high blood pressure and protein in urine and fluid retention. Left untreated, the condition can cause a range of problems such as growth restriction in babies and even foetal and maternal mortality.

Dr Julie Fisher, Reader in Biological NMR (nuclear magnetic resonance) and PhD student Elizabeth Turner from the School of Chemistry conducted the research with Jimmy Walker, Professor of Obstetrics at St James's University Hospital. The research was funded by the Engineering and Physical Sciences Research Council (EPSRC).

The team used a technique which is based on the same science as MRI scans but which operates on fluids taken from the body, to identify chemicals in the blood plasma of pregnant women. The amount of these chemicals was found to depend on whether the women were healthy or whether they were suffering from pre-eclampsia.

Dr Fisher said: "The concentration of certain chemicals such as amino acids and fat in the body has been found to vary in a way which is dependent on the health of the woman. We have found that some of these chemicals increase in concentration when the woman is suffering from pre-eclampsia whilst others decrease."

Professor Walker said: "Currently, we monitor all pregnant women in antenatal clinics for signs of pre-eclampsia which develops after 20 weeks of pregnancy. If an early prognostic tool was to become available, doctors and midwives could focus their attention and resources on caring for those more likely to develop the condition and instigate methods of prevention. This would be of significant benefit to the mother and her baby as well as the health service."

Dr Fisher said her work may ultimately be used as a basis for trying to find a cure for the condition. She said: "It is a long way down the line, but if we know what biological chemicals are affected by the disease, then we may be able to determine its cause and ultimately work towards preventing pre-eclampsia."

The findings were published last year in the medical journal Hypertension in Pregnancy and another paper on the subject will be published in the same journal in the spring. The discovery has been patented and is being developed by a spin-out company, MetaBio Ltd.

The work was funded by the Engineering and Physical Sciences Research Council (EPSRC), which sponsors around 40 students at the University of Leeds and University of Sheffield to carry out research in the White Rose Doctoral Training Centre (DTC); Physical Methods and Life Sciences.

Dr Fisher made the discovery after giving the project to a new research student as part of her training. She said: "Originally I had been looking at potential indicators of pre-eclampsia in red blood cells, following some earlier studies by Professor Walker. I stored the plasma simply because it seemed wasteful of material not to! Then, when Elizabeth was interested in our work, I asked her to see if there was anything relevant in the stored plasma, and we went on from there."


'/>"/>

Contact: Guy Dixon
G.Dixon@leeds.ac.uk
01-133-434-031
University of Leeds
Source:Eurekalert

Related medicine news :

1. On 30th Anniversary, Angioplasty Celebrated as Modern Medical Breakthrough in Stopping Heart Attack
2. drugstore.com and Revolution Health Group Announce Breakthrough Deal
3. New Round of Lupus Research Institute Awards Brings Promise of More Breakthroughs
4. CBaySystems Introduces CBayPraxis - A Breakthrough Solution Focused on Physician Practice Efficiency
5. Oosight Imaging System Enables a Breakthrough: The Viable Transfer of Genetic Material for Stem Cell Nuclear Reprogramming in Primates
6. Breakthrough in organ rejection diagnosis examines gene behavior
7. Safe Sex Passport Launches to Provide Breakthrough Protection Against STDs and HIV
8. Major breakthrough toward the treatment of HIV/HAART-associated Lipodystrophy Syndrome
9. Cardica Announces Live Webcast Demonstrating Breakthrough Device to Facilitate Beating Heart and Robotic Coronary Revascularization Surgery
10. TIME Magazine Names GeneSearch(TM) One of the Top 10 Medical Breakthroughs in 2007
11. California Breakthrough a Pivotal Moment in Fight to Transform Nations Health Care System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... FRANCISCO AND TEL AVIV (PRWEB) , ... June ... ... 3D-imaging sensor company whose technology makes it possible to see through objects, has ... challenging makers to create consumer apps with its fully programmable, Raspberry Pi-enabled 3D ...
(Date:6/28/2017)... ... June 28, 2017 , ... Drs. Steven Crandall, Karen ... treatment in Pittsburgh, PA, and Upper St. Clair, PA, without a referral. The doctors ... restoring the health of the temporomandibular joint and facial muscles that support it. ...
(Date:6/28/2017)... (PRWEB) , ... June 28, 2017 , ... David B. Sosin, a founding ... Illinois, took over the post of 2nd Vice President for the Illinois State Bar ... installed as the ISBA’s 3rd Vice President in 2016 following a state-wide election and served ...
(Date:6/28/2017)... ... 2017 , ... Schneider Insurance and Financial, a Yellowstone County ... Montana, is announcing a focused charity effort to gather regional support for the ... Zoo Montana provide students with current knowledge on the characteristics and behaviors of ...
(Date:6/27/2017)... ... June 27, 2017 , ... Nearly ... to survey data released today by the American Society for Dermatologic Surgery ... indicates the percentage of consumers considering a cosmetic medical procedure has doubled since ...
Breaking Medicine News(10 mins):
(Date:6/2/2017)...  NxStage Medical, Inc. (Nasdaq:  NXTM), a leading medical technology company ... demonstrating positive biochemical outcomes related to more frequent hemodialysis ... will be presented at the ERA-EDTA Congress being held ... . The research was conducted by ... Europe (KIHDNEy) Cohort team ...
(Date:5/30/2017)... 2017 DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... that it will be presenting at the 7th annual LD Micro ... Erez Raphael , CEO, of DarioHealth will be giving the presentation ... on June 6th & 7th, 2017 at the Luxe Sunset Bel ... micro-cap space. About LD Micro ...
(Date:5/30/2017)... AVIV, Israel , May 30, 2017 ... stage pharmaceutical Company specializing in the development of ... will present a company overview at three upcoming ... The 7th Annual LD Micro Invitational: ... Date:                     ...
Breaking Medicine Technology: