Navigation Links
Breakthrough in organ rejection diagnosis examines gene behavior
Date:11/19/2007

Edmonton, Canada November 19, 2007 - A new article appearing in American Journal of Transplantation describes a revolutionary technique for more clearly identifying the possibility of organ rejection in kidney transplants. The technique, which uses a microarray or Gene Chip, a process of examining DNA sequences, defines how major causes of organ disease leading to rejection share similar disturbances in gene behavior. The study is the first to show how gene sets, as opposed to single genes, can be used for diagnosis of rejection in individual patients, and offers new insight into the mechanisms of these gene changes.

The key problem in transplantation is to diagnose rejection. This has traditionally been done with the microscope by reading the appearance of the tissue. We are showing how this can be performed by reading the changes in expression of genes, and in particular, expression of sets of genes, says Philip F. Halloran, M.D., lead author of the study and Editor-in-Chief of American Journal of Transplantation. This is a more objective and accurate method of identifying the possibility of organ rejection.

The authors established sets of genes transcripts sets based on disease pathogenesis. They found a threshold for expression below which the studied biopsies did not show evidence of rejection. The findings displayed a series of major biologic indicators that occur before and during organ rejection. The results showed that previous histologic criteria, particularly relating to the cut-off between borderline organ acceptance and rejection, are unreliable.

The gene behaviors identified showed strong correlations, indicating that disturbances leading to transplant rejection have stereotyped structures. Samples from the study that lacked these disturbances did not lead to organ rejection.

The features of this structure are also found in lower levels in many forms of organ disease and injury. The system of reading biopsies that was developed in the study can be used with to help understand a variety of disease processes, says Halloran.


'/>"/>

Contact: Sean Wagner
swagner@bos.blackwellpublishing.com
781-388-8550
Blackwell Publishing Ltd.
Source:Eurekalert

Related medicine news :

1. On 30th Anniversary, Angioplasty Celebrated as Modern Medical Breakthrough in Stopping Heart Attack
2. drugstore.com and Revolution Health Group Announce Breakthrough Deal
3. New Round of Lupus Research Institute Awards Brings Promise of More Breakthroughs
4. CBaySystems Introduces CBayPraxis - A Breakthrough Solution Focused on Physician Practice Efficiency
5. Oosight Imaging System Enables a Breakthrough: The Viable Transfer of Genetic Material for Stem Cell Nuclear Reprogramming in Primates
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. NYC-area 1st: Morgan Stanley Childrens Hospital performs transcatheter pulmonary valve replacement
8. Pill box organizers increase HIV patients adherence and improve viral suppression
9. Donate Life America Dispels Myths About Organ & Tissue Donation Among Hispanics During National Hispanic Heritage Month
10. National Association of Subrogation Professionals (NASP), the Largest Insurance Subrogation Association in the World - Announced Today that Leslie Wiernik has Joined the Organization as Director of Education
11. HIDA Calls for Scrutiny of Group Purchasing Organization Distributor Fee Structure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... While it’s often important to take certain medications during the night, ... has identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL BOX ... eliminates the need to turn on a light when taking medication during the night, ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and Nutrition ... the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD market ... can be easily incorporated into liquid products, while reducing costs to end users. , ...
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of sub-acute ... of a disaster drill on October 3rd. , Apple Rehab participated with the Shelton ... well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The LTC-MAP ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... , ... Talented host, actor Rob Lowe, is introducing a ... episode of "Success Files," which is an award-winning educational program broadcasted on PBS ... in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve in ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
(Date:9/22/2017)... 2017  As the latest Obamacare repeal effort moves ... (R-LA) and Lindsey Graham (R-SC) medical ... device industry is in an odd place.  The industry ... excise tax on medical device sales passed along with ... patients, increased visits and hospital customers with the funding ...
(Date:9/19/2017)... 2017   ZirMed Inc ., a recognized leader in ... it has been ranked #1 by its users for the ... 2017 User Survey. ZirMed was recognized as the top-ranked end-to-end ... medical centers over 200 beds and holds one of the ... survey history. ...
Breaking Medicine Technology: