Navigation Links
Breakthrough in combating the side effects of quinine
Date:6/29/2009

Discovered back in the 1600s quinine was the first effective treatment in the fight against malaria and it continues to be a commonly used treatment against this devastating disease. But the drug is associated with a long list of side effects which can range from sickness and headaches to blindness, deafness and in rare cases death and until now no one knew why.

Scientists at The University of Nottingham have made a discovery that may explain many of the adverse side-effects associated with the drug and as a result have potentially found a way of combating them.

Their research, funded by The Sir Halley Stewart Trust, found that quinine can block a cell's ability to take up the essential amino acid tryptophan. The findings, published today in the Journal of Biological Chemistry, suggest that dietary tryptophan supplements could be a cheap and simple way to improve the performance of this important drug.

Dr Simon Avery and colleagues in the School of Biology used yeast genetics to examine the effects of quinine on a collection of 6000 yeast mutants, each one lacking exactly one of the yeast's 6000 genes. While quite different from humans, yeast is comparable on a cellular level and yeast is frequently, and successfully, used as a front-line agent in testing chemicals and small molecule drugs.

This detailed screening process revealed that strains of yeast unable to make tryptophan were extremely susceptible to quinine poisoning, which led them to identify a tryptophan transporter as a key quinine target (yeast that cannot make their own tryptophan have to rely exclusively on external sources, and thus die if tryptophan transport is blocked).

This discovery fits in well with evidence that quinine reactions are more severe in malnourished individuals. Tryptophan is an essential amino acid which means the human body cannot produce it we have to get it from the food we eat. Tryptophan is abundant in meat but limit
'/>"/>

Contact: Dr. Simon Avery
simon.avery@nottingham.ac.uk
44-011-595-13315
University of Nottingham
Source:Eurekalert

Page: 1 2

Related medicine news :

1. On 30th Anniversary, Angioplasty Celebrated as Modern Medical Breakthrough in Stopping Heart Attack
2. drugstore.com and Revolution Health Group Announce Breakthrough Deal
3. New Round of Lupus Research Institute Awards Brings Promise of More Breakthroughs
4. CBaySystems Introduces CBayPraxis - A Breakthrough Solution Focused on Physician Practice Efficiency
5. Oosight Imaging System Enables a Breakthrough: The Viable Transfer of Genetic Material for Stem Cell Nuclear Reprogramming in Primates
6. Breakthrough in organ rejection diagnosis examines gene behavior
7. Safe Sex Passport Launches to Provide Breakthrough Protection Against STDs and HIV
8. Major breakthrough toward the treatment of HIV/HAART-associated Lipodystrophy Syndrome
9. Cardica Announces Live Webcast Demonstrating Breakthrough Device to Facilitate Beating Heart and Robotic Coronary Revascularization Surgery
10. TIME Magazine Names GeneSearch(TM) One of the Top 10 Medical Breakthroughs in 2007
11. California Breakthrough a Pivotal Moment in Fight to Transform Nations Health Care System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... FL (PRWEB) August 27, 2014 Millennium ... now a sponsor for Florida Mental Health Counselors Association ... benefits the new sponsorship is sure to provide. , ... professional needs of Florida’s licensed mental health counselors. The ... the American Counseling Association (ACA) and since then, it ...
(Date:8/27/2014)... Shawna's new book, released in ebook and ... which a brand-new technique she created. Seed digging incorporates ... bring permanent healing quickly. , According to Burns, Seed ... cured on a daily basis. It teaches people how ... incredible inner peace with only a few simple steps. ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Locating an ... a consumer to present personal information before rates would ... way that life insurance quotes are distributed online using ... The term plans that an adult has access to ... known U.S. companies. The system for quotation distribution built ...
(Date:8/27/2014)... Skirt Sports , the innovative women’s running apparel ... Kathrine Switzer, most noted for her brave running of the ... of women’s running clothes that unites the history of women’s ... Movement. , “It is such an honor to ... “Kathrine is the original Skirt – she stood strong, pushing ...
(Date:8/27/2014)... 27, 2014 New Jersey’s own Morgan ... Ridgewood County Club during The Barclays – and thanks ... of the tournament’s four rounds, stepped his way into ... Cross Blue Shield of New Jersey (Horizon BCBNSNJ) Walking ... Wyckoff native playing before family and friends at the ...
Breaking Medicine News(10 mins):Health News:Millennium Treatment Group Sponsors Florida Mental Health Counselors Association 2Health News:Shawna Burns, Counselor, Releases Debut Book, "Seed Digging," to Improve Lives of Children and Adults with Addictions and Mental Health Disorders 2Health News:Life Insurance Quotes for Term Policies Now Found at Insurer Website Online 2Health News:Skirt Sports Launches Clothing Line with Legendary Runner Kathrine Switzer 2Health News:Morgan Hoffmann, PGA TOUR Pro & Wyckoff Native, golfs and walks his way to top 10 finish at The Barclays while raising additional $7,500 for charity 2
... with Frequently ... Misdiagnosed Condition, WASHINGTON, ... (IC) Awareness Day, the National Association of Nurse,Practitioners in Women,s ... released the results of the first survey of IC,patients highlighting ...
... Funding will Accelerate Expansion of Industry Leading Health and Human ... Services On-Demand Software Solutions, ... the industry-leading provider of software solutions for the,health and human ... equity and debt financing totaling $28 million. The round was ...
... seasonal * Online advertised vacancies are ... the year gains in advertised ... vacancies, * ... 31 In October there were 4,161,700,online advertised vacancies, a decrease of 108,300 ...
... even Alzheimer,s, experts say , , WEDNESDAY, Oct. 31 (HealthDay News) ... brain,s own stem cells may have the ability to restore ... by protecting existing cells and promoting neuronal connections. , In ... were able to bring the rodents, memory back to healthy ...
... seventh leading cause of cancer death worldwide, the occurrence ... and gender. Esophageal cancer is thought to be triggered ... the host genome. Researchers have long been seeking the ... on gene-environment interaction and gene polymorphisms for esophageal cancer. ...
... undertaking elective surgery to remove part or all of the ... be too high, warn researchers in a study published on ... term for chronic inflammation of the intestine and includes ulcerative ... people in the UK are affected and many people will ...
Cached Medicine News:Health News:October 31 is National Interstitial Cystitis (IC) Awareness Day 2Health News:October 31 is National Interstitial Cystitis (IC) Awareness Day 3Health News:October 31 is National Interstitial Cystitis (IC) Awareness Day 4Health News:Harmony Information Systems Raises $28 Million in Series B Financing from JMI Equity, Updata Partners, ORIX Venture Finance and Comerica Bank 2Health News:Harmony Information Systems Raises $28 Million in Series B Financing from JMI Equity, Updata Partners, ORIX Venture Finance and Comerica Bank 3Health News:Harmony Information Systems Raises $28 Million in Series B Financing from JMI Equity, Updata Partners, ORIX Venture Finance and Comerica Bank 4Health News:Online Advertised Job Vacancies Dip in October, The Conference Board Reports Today 2Health News:Online Advertised Job Vacancies Dip in October, The Conference Board Reports Today 3Health News:Online Advertised Job Vacancies Dip in October, The Conference Board Reports Today 4Health News:Online Advertised Job Vacancies Dip in October, The Conference Board Reports Today 5Health News:Online Advertised Job Vacancies Dip in October, The Conference Board Reports Today 6Health News:Stem Cells Restore Memory in Mice 2Health News:Stem Cells Restore Memory in Mice 3Health News:ADH2 and ALDH2 are associated with esophageal cancer 2Health News:Threshold for bowel surgery may be too high, warn experts 2
(Date:8/27/2014)...  CVS Caremark (NYSE: CVS ) announced ... with MedStar Health, a leading health care system with ... the Washington, DC , region, which ... for patients. Through this clinical affiliation, MedStar Health patients ... counseling, chronic disease monitoring and wellness programs at CVS/pharmacy ...
(Date:8/27/2014)... NINGBO, China , Aug. 27, 2014  Amerigen ... Ltd, ("Menovo") today announced they had entered into a ... targeting the United States market. ... will jointly develop products for Amerigen to commercialize in ... be responsible for manufacturing API and finished product whereas ...
(Date:8/27/2014)... , Aug. 27, 2014 /PRNewswire-iReach/ -- "Fatty Liver Disease ... the Fatty Liver Disease clinical trial scenario. This report ... clinical trials on Fatty Liver Disease . It includes ... status as per the site of trial conduction across ... disease clinical trials by their phase, trial status, prominence ...
Breaking Medicine Technology:CVS Caremark Announces New Clinical Affiliation with MedStar Health 2CVS Caremark Announces New Clinical Affiliation with MedStar Health 3Amerigen Pharmaceuticals Limited and the Ningbo Menovo Pharmaceutical Co., Ltd, today announced they had entered into a collaboration agreement regarding the development of generic pharmaceuticals, primarily targeting the United States market 2Fatty Liver Disease Therapeutics Clinical Trials Market Review 2014 Analysis Report Available at MarketOptimizer.org 2Fatty Liver Disease Therapeutics Clinical Trials Market Review 2014 Analysis Report Available at MarketOptimizer.org 3Fatty Liver Disease Therapeutics Clinical Trials Market Review 2014 Analysis Report Available at MarketOptimizer.org 4Fatty Liver Disease Therapeutics Clinical Trials Market Review 2014 Analysis Report Available at MarketOptimizer.org 5
... Rapid 5 minutes immunoassay, based on ... a monoclonal antibody, for the qualitative ... human stool. The Premier Platinum HpSA, ... after extensive evaluation, was accepted as ...
Unitary one step immuno-chromatographic assay for the qualitative detection of infectious mononucleosis heterophile antibodies in human serum, plasma or whole blood....
The NOW® Flu B test is the most frequently adopted rapid flu test on the market today. Testing could not be easier and the results are available in 15 minutes. Now you can focus on the results an...
... PRISM 310 Genetic Analyzer is an automated ... range of sequencing and fragment analysis applications. ... forensic labs who incorporate genetic analysis into ... the ideal alternative to gel-based DNA analysis ...
Medicine Products: