Navigation Links
Breakthrough in Predicting Invasive Breast Cancer
Date:4/28/2010

New way to predict spread could avoid overly aggressive treatment, researchers say

WEDNESDAY, April 28 (HealthDay News) -- A new way to predict whether women with the most common form of breast cancer are at risk of developing more invasive tumors later in life will help those women be more selective about their treatment, U.S. researchers report.

They analyzed the medical records of 1,162 women, aged 40 and older, who were diagnosed with ductal carcinoma in situ (DCIS) and underwent lumpectomy, which is surgical removal of the tumor and some of the surrounding normal tissue.

The researchers found that two factors -- method of diagnosis and expression of several biomarkers -- were predictors of the risk of developing invasive breast cancer within eight years of being diagnosed with DCIS.

The risk was higher among women who had a breast lump diagnosed as DCIS than among those whose DCIS was diagnosed by mammography. Women with high levels of the biomarkers p16, cyclooxygenase-2, and Ki67 in DCIS tissue were also more likely to develop invasive breast cancer.

Women with the lowest risk had only a 2 percent chance of developing invasive breast cancer at five years after diagnosis and a 4 percent chance at eight years.

As a result of the research, doctors can better predict whether women treated with a lumpectomy only are at a very low or a high risk of developing invasive cancer later.

The findings mean that women with DCIS "will have much more information, so they can better know their risk of developing invasive cancer. It will lead to a more personalized approach to treatment. As many as 44 percent of patients with DCIS may not require any further treatment, and can rely instead on surveillance," study author Dr. Karla Kerlikowske, a professor of medicine, and epidemiology and biostatistics at the University of California, San Francisco Helen Diller Comprehensive Cancer Center, said in a news release.

Only about 1 percent to 2 percent of women with DCIS die of breast cancer within 10 years of diagnosis, but many choose aggressive treatment because they don't fully understand their risk of developing invasive breast cancer, the researchers said.

The study appears online April 28 in the Journal of the National Cancer Institute.

More information

Breastcancer.org has more about DCIS.



-- Robert Preidt



SOURCE: University of California, San Francisco, news release, April 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Breakthrough by Danish scientists in preventing maternal malaria
2. Stem cell breakthrough: Bone marrow cells are the answer
3. Breakthrough heart scanner will allow earlier diagnosis
4. Breakthrough Approach to Age-old Ailment, Renowned Doctor Introduces Powerful Headache Medicine
5. Medical Breakthrough: Drug Free Strategy Shows Promise for Reversing or Halting Osteoporosis for Michigan Men and Women
6. Autism Research at the Childrens Hospital of Philadelphia Is Among Time Magazines Top 10 Medical Breakthroughs
7. Breakthrough Invention: New Device Makes Contact Lenses and Eye Drops Easier Than Ever Before
8. Leading Orthopaedic Surgeon Thomas A. Einhorn Offers Breakthrough Non-Embryonic Stem Cell Surgery to Reverse Early Necrosis of the Hip
9. Now Millions Suffering With Alcohol Addiction Can Get Breakthrough Recovery in Ultimate Privacy
10. Breakthrough Treatment for Diabetic Neuropathy Introduced
11. Biggest Medical Breakthroughs and Milestones of the Last Decade Broadcast on SIRIUS XMs Doctor Radio Channel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... ... newest advanced absorption cannabidiol (CBD) serum, “NANOCALM 300” Microemulsified Hemp Extract. This ... instant absorption from the mouth into the bloodstream. Far outpacing the ...
(Date:2/22/2017)... ... February 22, 2017 , ... Becker’s Spine Review, the leading ... Michigan neurosurgeon Jay Jagannathan, M.D., as a “Spine Surgeon to Know.” http://www.beckersspine.com/spine-leaders/item/35348- ... in Michigan performing minimally invasive back surgery that often results in less post-operative ...
(Date:2/22/2017)... ... February 22, 2017 , ... The SeniorCare Investor will host an important ... February 23, 2017, at 1:00 PM ET. A recording of the webinar will also ... Webinar Series. , If you want to find out what really happened in the ...
(Date:2/22/2017)... ... , ... BrightStar Care Charleston , a home care and medical staffing ... (MUSC) Center on Aging’s Senior Expo on Thursday, March 23, 2017, at the ... resource in our community. We are thrilled to participate in this event because we ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... pipeline and the number of African American/Black students who want to become physicians. ... to pursue their careers as physicians in the Oakland/San Francisco Northern California, Bay ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... 22, 2017 Kineta, Inc., a biotechnology ... immune modulating therapies, today announced that KCP-400 (RgIA4), ... receptor (nAChR), demonstrates robust chronic pain relief and ... study also establishes the a9a10 nAChR as a ... pain. The findings were reported online in the ...
(Date:2/22/2017)... and HAMBURG, Germany , February 22, 2017 ... precision oncology headquartered in Hamburg, Germany and ... research institution, announced today a collaboration to support the first Indian ... research. ... Indivumed signed an agreement with an initial three-year term. The collaboration ...
(Date:2/21/2017)... NEW YORK , Feb. 21, 2017 ... equipment with specialized versions are used to monitor physiological ... or as remote patient monitors. Remote patient monitoring is ... of the patient monitoring equipment in the market. Hence, ... integrated with smartphones and applications, which can send test ...
Breaking Medicine Technology: