Navigation Links
Breakthrough in Predicting Invasive Breast Cancer
Date:4/28/2010

New way to predict spread could avoid overly aggressive treatment, researchers say

WEDNESDAY, April 28 (HealthDay News) -- A new way to predict whether women with the most common form of breast cancer are at risk of developing more invasive tumors later in life will help those women be more selective about their treatment, U.S. researchers report.

They analyzed the medical records of 1,162 women, aged 40 and older, who were diagnosed with ductal carcinoma in situ (DCIS) and underwent lumpectomy, which is surgical removal of the tumor and some of the surrounding normal tissue.

The researchers found that two factors -- method of diagnosis and expression of several biomarkers -- were predictors of the risk of developing invasive breast cancer within eight years of being diagnosed with DCIS.

The risk was higher among women who had a breast lump diagnosed as DCIS than among those whose DCIS was diagnosed by mammography. Women with high levels of the biomarkers p16, cyclooxygenase-2, and Ki67 in DCIS tissue were also more likely to develop invasive breast cancer.

Women with the lowest risk had only a 2 percent chance of developing invasive breast cancer at five years after diagnosis and a 4 percent chance at eight years.

As a result of the research, doctors can better predict whether women treated with a lumpectomy only are at a very low or a high risk of developing invasive cancer later.

The findings mean that women with DCIS "will have much more information, so they can better know their risk of developing invasive cancer. It will lead to a more personalized approach to treatment. As many as 44 percent of patients with DCIS may not require any further treatment, and can rely instead on surveillance," study author Dr. Karla Kerlikowske, a professor of medicine, and epidemiology and biostatistics at the University of California, San Francisco Helen Diller Comprehensive Cancer Center, said in a news release.

Only about 1 percent to 2 percent of women with DCIS die of breast cancer within 10 years of diagnosis, but many choose aggressive treatment because they don't fully understand their risk of developing invasive breast cancer, the researchers said.

The study appears online April 28 in the Journal of the National Cancer Institute.

More information

Breastcancer.org has more about DCIS.



-- Robert Preidt



SOURCE: University of California, San Francisco, news release, April 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Breakthrough by Danish scientists in preventing maternal malaria
2. Stem cell breakthrough: Bone marrow cells are the answer
3. Breakthrough heart scanner will allow earlier diagnosis
4. Breakthrough Approach to Age-old Ailment, Renowned Doctor Introduces Powerful Headache Medicine
5. Medical Breakthrough: Drug Free Strategy Shows Promise for Reversing or Halting Osteoporosis for Michigan Men and Women
6. Autism Research at the Childrens Hospital of Philadelphia Is Among Time Magazines Top 10 Medical Breakthroughs
7. Breakthrough Invention: New Device Makes Contact Lenses and Eye Drops Easier Than Ever Before
8. Leading Orthopaedic Surgeon Thomas A. Einhorn Offers Breakthrough Non-Embryonic Stem Cell Surgery to Reverse Early Necrosis of the Hip
9. Now Millions Suffering With Alcohol Addiction Can Get Breakthrough Recovery in Ultimate Privacy
10. Breakthrough Treatment for Diabetic Neuropathy Introduced
11. Biggest Medical Breakthroughs and Milestones of the Last Decade Broadcast on SIRIUS XMs Doctor Radio Channel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: