Navigation Links
Breakthrough in Predicting Invasive Breast Cancer

New way to predict spread could avoid overly aggressive treatment, researchers say

WEDNESDAY, April 28 (HealthDay News) -- A new way to predict whether women with the most common form of breast cancer are at risk of developing more invasive tumors later in life will help those women be more selective about their treatment, U.S. researchers report.

They analyzed the medical records of 1,162 women, aged 40 and older, who were diagnosed with ductal carcinoma in situ (DCIS) and underwent lumpectomy, which is surgical removal of the tumor and some of the surrounding normal tissue.

The researchers found that two factors -- method of diagnosis and expression of several biomarkers -- were predictors of the risk of developing invasive breast cancer within eight years of being diagnosed with DCIS.

The risk was higher among women who had a breast lump diagnosed as DCIS than among those whose DCIS was diagnosed by mammography. Women with high levels of the biomarkers p16, cyclooxygenase-2, and Ki67 in DCIS tissue were also more likely to develop invasive breast cancer.

Women with the lowest risk had only a 2 percent chance of developing invasive breast cancer at five years after diagnosis and a 4 percent chance at eight years.

As a result of the research, doctors can better predict whether women treated with a lumpectomy only are at a very low or a high risk of developing invasive cancer later.

The findings mean that women with DCIS "will have much more information, so they can better know their risk of developing invasive cancer. It will lead to a more personalized approach to treatment. As many as 44 percent of patients with DCIS may not require any further treatment, and can rely instead on surveillance," study author Dr. Karla Kerlikowske, a professor of medicine, and epidemiology and biostatistics at the University of California, San Francisco Helen Diller Comprehensive Cancer Center, said in a news release.

Only about 1 percent to 2 percent of women with DCIS die of breast cancer within 10 years of diagnosis, but many choose aggressive treatment because they don't fully understand their risk of developing invasive breast cancer, the researchers said.

The study appears online April 28 in the Journal of the National Cancer Institute.

More information has more about DCIS.

-- Robert Preidt

SOURCE: University of California, San Francisco, news release, April 28, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Breakthrough by Danish scientists in preventing maternal malaria
2. Stem cell breakthrough: Bone marrow cells are the answer
3. Breakthrough heart scanner will allow earlier diagnosis
4. Breakthrough Approach to Age-old Ailment, Renowned Doctor Introduces Powerful Headache Medicine
5. Medical Breakthrough: Drug Free Strategy Shows Promise for Reversing or Halting Osteoporosis for Michigan Men and Women
6. Autism Research at the Childrens Hospital of Philadelphia Is Among Time Magazines Top 10 Medical Breakthroughs
7. Breakthrough Invention: New Device Makes Contact Lenses and Eye Drops Easier Than Ever Before
8. Leading Orthopaedic Surgeon Thomas A. Einhorn Offers Breakthrough Non-Embryonic Stem Cell Surgery to Reverse Early Necrosis of the Hip
9. Now Millions Suffering With Alcohol Addiction Can Get Breakthrough Recovery in Ultimate Privacy
10. Breakthrough Treatment for Diabetic Neuropathy Introduced
11. Biggest Medical Breakthroughs and Milestones of the Last Decade Broadcast on SIRIUS XMs Doctor Radio Channel
Post Your Comments:
(Date:6/24/2016)... ... 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 ... by their peers for this recognition are considered among the top 2 percent of ... honors as members of this year’s Legal Elite Hall of Fame: Miami Shareholders ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. ... magazine’s Code Talker Award, an essay contest in which patients and their families pay ... be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... feeding the Frederick area economy by obtaining investment capital for emerging technology companies. ... 2½ years that have already resulted in more than a million dollars of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
Breaking Medicine Technology: