Navigation Links
Breakthrough by Danish scientists in preventing maternal malaria
Date:2/4/2010

Researchers at the University of Copenhagen have become the first in the world to synthesize the entire protein that is responsible for life-threatening malaria in pregnant women and their unborn children. The protein known as VAR2CSA enables malaria parasites to accumulate in the placenta and can therefore potentially be used as the main component in a vaccine to trigger antibodies that protect pregnant women against malaria. The research team is now planning to test the efficacy of the protein-based vaccine on humans. The hope is that within 10 years all African girls could be vaccinated against maternal malaria, thereby preventing more than 200,000 deaths a year.

Each year, 25 million pregnant women in sub-Saharan Africa run the risk of contracting malaria. Women who have become infected with malaria parasites during their first pregnancy are at considerable risk of severe anaemia and significant impairment of foetal growth. The malaria parasites accumulate in the placenta, resulting in children being born prematurely and underweight. These women are also at greater risk of dying during pregnancy and childbirth. Maternal malaria is the cause of death of between 100,000 and 200,000 newborn babies and 10,000 women each year.

"The malaria research group discovered the protein VAR2CSA, which is responsible for malaria parasite binding in the placenta, in 2003," says Associate Professor Ali Salanti from the centre. "The aim is to produce a vaccine based on VAR2CSA which elicits antibodies that stop the parasite from binding to the placenta. The challenge for us has been to produce the entire protein in the laboratory, as it is very large and so technically complex. Now that we've managed to do this, we're a big step closer to developing a human vaccine, as we can already test it as a vaccine in animals."

"In collaboration with scientists at The Tanzanian National Institute for Medical Research, we've tested the antibodies that were produced in the laboratory on a number of malaria parasites from pregnant women in Tanzania," says Professor Thor Theander from the centre. "These antibodies seem to be effective at preventing the parasite from accumulating in the placental tissue. The next step is to investigate whether we can elicit the same antibodies and so protect against the disease by vaccinating humans. Then the vaccine will be a reality."


'/>"/>

Contact: Sandra Szivos
sasz@sund.ku.dk
453-532-6921
University of Copenhagen
Source:Eurekalert

Related medicine news :

1. On 30th Anniversary, Angioplasty Celebrated as Modern Medical Breakthrough in Stopping Heart Attack
2. drugstore.com and Revolution Health Group Announce Breakthrough Deal
3. New Round of Lupus Research Institute Awards Brings Promise of More Breakthroughs
4. CBaySystems Introduces CBayPraxis - A Breakthrough Solution Focused on Physician Practice Efficiency
5. Oosight Imaging System Enables a Breakthrough: The Viable Transfer of Genetic Material for Stem Cell Nuclear Reprogramming in Primates
6. Breakthrough in organ rejection diagnosis examines gene behavior
7. Safe Sex Passport Launches to Provide Breakthrough Protection Against STDs and HIV
8. Major breakthrough toward the treatment of HIV/HAART-associated Lipodystrophy Syndrome
9. Cardica Announces Live Webcast Demonstrating Breakthrough Device to Facilitate Beating Heart and Robotic Coronary Revascularization Surgery
10. TIME Magazine Names GeneSearch(TM) One of the Top 10 Medical Breakthroughs in 2007
11. California Breakthrough a Pivotal Moment in Fight to Transform Nations Health Care System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
(Date:6/24/2016)... San Francisco, CA (PRWEB) , ... June 24, ... ... at CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has ... , self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , ...
(Date:6/24/2016)... ... 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ... raise to $12 an hour by 2020 and then adjusting it yearly to increase at ... the minimum wage, assure the wage floor does not erode again, and make future increases ...
(Date:6/24/2016)... ... 2016 , ... EB Medicine presented its first-ever “Issue of ... in Ponte Vedra Beach, FL. The awards honor the outstanding work of leading ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the efforts ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions today ... cultivation and processing operations at its production facility, and opened its first two ... the manufacturer of a complete system of proactive air and surface purification solutions ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 26, 2016 Story Highlights: ... models within the health care industry is causing providers ... , Deloitte offers a suite of solutions for ... impacting efficient cost optimization: labor resource analysis, revenue cycle ... facilitate better outcomes and better economics ...
(Date:6/24/2016)... N.J. , June 24, 2016  Collagen ... the design, development and manufacturing of collagen and ... regeneration announced today that Bill Messer ... and Marketing to further leverage the growing portfolio ... medical devices. Bill joins the Collagen ...
(Date:6/24/2016)... June 24, 2016   Bay Area Lyme ... Dean Center for Tick Borne Illness , ... Rehabilitation, MIT Hacking Medicine, University of California, Berkeley, ... announced the five finalists of Lyme Innovation ... More than 100 scientists, clinicians, researchers, entrepreneurs, and ...
Breaking Medicine Technology: