Navigation Links
Bread mold may hold secret to eliminating disease-causing genes
Date:5/8/2008

COLUMBIA, Mo. When most people discover mold on their bread, they immediately throw it out. Others see a world of possibilities in the tiny fungus. A University of Missouri scientist, along with a collaborative research team, has examined a new mechanism in the reproductive cycle of a certain species of mold. This mechanism protects the organism from genetic abnormalities by silencing unmatched genes during meiosis (sexual reproduction). The finding could have implications for higher organisms and may lead to precise targeting of unwanted genes, such as those from the HIV virus.

Meiotic silencing also occurs in worms, mice and human beings, said Patrick Shiu, assistant professor of biological sciences in the MU College of Arts and Science. Its unlikely that all share the same mechanism, but the principle of targeting unpaired DNA for silencing seems to be found in both simple and complex organisms. Knowing the process of how DNA in molds is targeted for silencing could be important for silencing genes you dont want to be expressed, like disease-causing genes.

Shiu and his colleagues discovered that each sexual cell in mold has an internal mechanism that scans paired chromosomes for anomalies. The researchers found that when one chromosome in a pair carries an extra copy of a gene not found in its partner chromosome, it is a good indication of an intruder and the fungus will turn off all copies of that gene during meiosis. The researchers call this process "meiotic silencing by unpaired DNA, or MSUD.

"MSUD defends the fungus against invasion at a time when chromosomes are especially vulnerable to the spread of viruses and insertion sequences," Shiu said.

Shius research enhances understanding of how to shut off undesirable genes, sheds light on the genetic components of the MSUD pathway, and may have applications in a number of industries, including pharmaceuticals and agriculture.

Because of his contribution to the field of genetics, Shiu recently received the Beadle and Tatum Award, named after Nobel Prize-winning geneticists George Beadle and Edward Tatum. The award was established to recognize outstanding and original research by a scientist using Neurospora, a type of bread mold, as a model organism.


'/>"/>

Contact: Bryan E. Jones
jonesbry@missouri.edu
573-882-9144
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Most Baby Boomers Overestimate Breadth and Depth of Public Safety Net for Disabled Workers
2. Dempsters Smart(TM) 100% Whole Grain Wheat Bread Launched With lifesDHA(TM)
3. New Assessment Highlights Breadth and Depth of Looming Public Health Workforce Crisis
4. Right breakfast bread keeps blood sugar in check all day
5. Secret to Treating Tinnitus in Vets May Be Unlocked in Zebrafish
6. Secretary Cortes Calls Latino Community to Action Against Ailing Health Care System
7. State Health Secretary Visits City of Chester for Cover the Uninsured Week
8. Aspirin-like compounds increase insulin secretion in otherwise healthy obese people
9. Fleeting Facial Expressions Reveal Deep Secrets
10. Seattle-Based Law Firm Williams Kastner Receives Significant Defense Verdict in Trade Secret Business Litigation Case
11. PA Secretary of Public Welfare Releases 2007 Child Abuse Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, ... at his family verbally and physically. , “When something upset him, he couldn’t control his ... it. He would throw rocks at my other children and say he was going to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda ... orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including ... accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 ... today announced the appointment of Dr. Edward ... as a Non-Executive Director, effective June 23, 2016.Dr. ... Compensation and Nominations and Governance Committees.  As a ... will provide independent expertise and strategic counsel to ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Market - Forecast to 2022" report to their offering. ... method for the patients with kidney failure, it replaces the ... from the patient,s blood and thus the treatment helps to ... chloride in balance. Increasing number of ESRD ...
(Date:6/23/2016)... -- In a startling report released today, National Safety Council ... comprehensive, proven plan to eliminate prescription opioid overdoses. Prescription ... are tackling the worst drug crisis in recorded U.S. history, assigned ... Kentucky , New Mexico , ... 28 failing states, three – Michigan , ...
Breaking Medicine Technology: