Navigation Links
Bread mold may hold secret to eliminating disease-causing genes
Date:5/8/2008

COLUMBIA, Mo. When most people discover mold on their bread, they immediately throw it out. Others see a world of possibilities in the tiny fungus. A University of Missouri scientist, along with a collaborative research team, has examined a new mechanism in the reproductive cycle of a certain species of mold. This mechanism protects the organism from genetic abnormalities by silencing unmatched genes during meiosis (sexual reproduction). The finding could have implications for higher organisms and may lead to precise targeting of unwanted genes, such as those from the HIV virus.

Meiotic silencing also occurs in worms, mice and human beings, said Patrick Shiu, assistant professor of biological sciences in the MU College of Arts and Science. Its unlikely that all share the same mechanism, but the principle of targeting unpaired DNA for silencing seems to be found in both simple and complex organisms. Knowing the process of how DNA in molds is targeted for silencing could be important for silencing genes you dont want to be expressed, like disease-causing genes.

Shiu and his colleagues discovered that each sexual cell in mold has an internal mechanism that scans paired chromosomes for anomalies. The researchers found that when one chromosome in a pair carries an extra copy of a gene not found in its partner chromosome, it is a good indication of an intruder and the fungus will turn off all copies of that gene during meiosis. The researchers call this process "meiotic silencing by unpaired DNA, or MSUD.

"MSUD defends the fungus against invasion at a time when chromosomes are especially vulnerable to the spread of viruses and insertion sequences," Shiu said.

Shius research enhances understanding of how to shut off undesirable genes, sheds light on the genetic components of the MSUD pathway, and may have applications in a number of industries, including pharmaceuticals and agriculture.

Because of his contribution to the field of genetics, Shiu recently received the Beadle and Tatum Award, named after Nobel Prize-winning geneticists George Beadle and Edward Tatum. The award was established to recognize outstanding and original research by a scientist using Neurospora, a type of bread mold, as a model organism.


'/>"/>

Contact: Bryan E. Jones
jonesbry@missouri.edu
573-882-9144
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Most Baby Boomers Overestimate Breadth and Depth of Public Safety Net for Disabled Workers
2. Dempsters Smart(TM) 100% Whole Grain Wheat Bread Launched With lifesDHA(TM)
3. New Assessment Highlights Breadth and Depth of Looming Public Health Workforce Crisis
4. Right breakfast bread keeps blood sugar in check all day
5. Secret to Treating Tinnitus in Vets May Be Unlocked in Zebrafish
6. Secretary Cortes Calls Latino Community to Action Against Ailing Health Care System
7. State Health Secretary Visits City of Chester for Cover the Uninsured Week
8. Aspirin-like compounds increase insulin secretion in otherwise healthy obese people
9. Fleeting Facial Expressions Reveal Deep Secrets
10. Seattle-Based Law Firm Williams Kastner Receives Significant Defense Verdict in Trade Secret Business Litigation Case
11. PA Secretary of Public Welfare Releases 2007 Child Abuse Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... California (PRWEB) , ... January 17, 2017 , ... ... have a point of difference. Eden Activewear is a stand-out company for several ... are exclusively online and only manufacture on demand, this is called 'Agile' manufacturing ...
(Date:1/17/2017)... ... January 17, 2017 , ... Healthful Balance announces ... company, owned and operated by Ed Stroup, was created to offer the highest ... highest level of customer service. Healthful Balance products can be purchased online through ...
(Date:1/17/2017)... Grove Village, IL (PRWEB) , ... January 17, ... ... for musicians and music enthusiasts at the National Association of Music Merchants (NAMM) ... January 19 – 22, 2017. , Etymotic’s ER•4® has long been the gold ...
(Date:1/17/2017)... ... January 17, 2017 , ... Mirror Mirror Beauty Boutique, Houston’s ... honor of Diamond Level in Zeltiq’s Crystal Rewards Program. Practice founder, Paul Vitenas, MD ... elite group of providers. , Produced by Zeltiq, CoolSculpting is approved by the ...
(Date:1/17/2017)... ... January 17, 2017 , ... Surgeons from ... primary eye care practitioners on the latest breakthroughs in the prevention, diagnosis and ... Education Symposium, according to eye surgeon, Jeffrey Martin, MD, FACS, Chief Executive Officer ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... Md. , Jan. 18, 2017  Kratom ... the coffee family, are often used to prepare ... consumed by several million Americans annually to increase ... a natural remedy for minor aches and pains. ... effects is intended to assist FDA and DEA ...
(Date:1/18/2017)... , Jan. 18, 2017 Safe Rx LLC ... pharmacies based in Loveland, Colorado , ... (LPVs) in selected Good Day locations.     ... cost-effective alternative for secure storage," said Milton Cohen ... than the price of a cup of coffee, you ...
(Date:1/18/2017)... DIEGO , Jan. 18, 2017 ... solutions for cell and advanced therapies , has ... French biopharmaceutical company developing "tumor starvation" treatments for ... medical needs. Under the agreement, Invetech will develop ... based on Erytech,s proprietary ERYCAPS technology platform, which ...
Breaking Medicine Technology: