Navigation Links
Bread mold may hold secret to eliminating disease-causing genes
Date:5/8/2008

COLUMBIA, Mo. When most people discover mold on their bread, they immediately throw it out. Others see a world of possibilities in the tiny fungus. A University of Missouri scientist, along with a collaborative research team, has examined a new mechanism in the reproductive cycle of a certain species of mold. This mechanism protects the organism from genetic abnormalities by silencing unmatched genes during meiosis (sexual reproduction). The finding could have implications for higher organisms and may lead to precise targeting of unwanted genes, such as those from the HIV virus.

Meiotic silencing also occurs in worms, mice and human beings, said Patrick Shiu, assistant professor of biological sciences in the MU College of Arts and Science. Its unlikely that all share the same mechanism, but the principle of targeting unpaired DNA for silencing seems to be found in both simple and complex organisms. Knowing the process of how DNA in molds is targeted for silencing could be important for silencing genes you dont want to be expressed, like disease-causing genes.

Shiu and his colleagues discovered that each sexual cell in mold has an internal mechanism that scans paired chromosomes for anomalies. The researchers found that when one chromosome in a pair carries an extra copy of a gene not found in its partner chromosome, it is a good indication of an intruder and the fungus will turn off all copies of that gene during meiosis. The researchers call this process "meiotic silencing by unpaired DNA, or MSUD.

"MSUD defends the fungus against invasion at a time when chromosomes are especially vulnerable to the spread of viruses and insertion sequences," Shiu said.

Shius research enhances understanding of how to shut off undesirable genes, sheds light on the genetic components of the MSUD pathway, and may have applications in a number of industries, including pharmaceuticals and agriculture.

Because of his contribution to the field of genetics, Shiu recently received the Beadle and Tatum Award, named after Nobel Prize-winning geneticists George Beadle and Edward Tatum. The award was established to recognize outstanding and original research by a scientist using Neurospora, a type of bread mold, as a model organism.


'/>"/>

Contact: Bryan E. Jones
jonesbry@missouri.edu
573-882-9144
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Most Baby Boomers Overestimate Breadth and Depth of Public Safety Net for Disabled Workers
2. Dempsters Smart(TM) 100% Whole Grain Wheat Bread Launched With lifesDHA(TM)
3. New Assessment Highlights Breadth and Depth of Looming Public Health Workforce Crisis
4. Right breakfast bread keeps blood sugar in check all day
5. Secret to Treating Tinnitus in Vets May Be Unlocked in Zebrafish
6. Secretary Cortes Calls Latino Community to Action Against Ailing Health Care System
7. State Health Secretary Visits City of Chester for Cover the Uninsured Week
8. Aspirin-like compounds increase insulin secretion in otherwise healthy obese people
9. Fleeting Facial Expressions Reveal Deep Secrets
10. Seattle-Based Law Firm Williams Kastner Receives Significant Defense Verdict in Trade Secret Business Litigation Case
11. PA Secretary of Public Welfare Releases 2007 Child Abuse Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... ... February 21, 2017 , ... Robins & ... in Durant, Oklahoma, on Feb. 21. , The celebration began with a ribbon ... clinic employees, the construction team and tribal leadership. , Choctaw Nation Durant ...
(Date:2/21/2017)... ... ... Individuals who have been diagnosed with cancer are at ... management. Regular exercise in proper environments has been shown to benefit these patients, ... 23, 2017, 1:00-2:00 p.m. E.S.T., a dynamic HydroWorx webinar led by ...
(Date:2/21/2017)... ... February 21, 2017 , ... Each ... Black History Month (officially African American History Month ). This ... society of a diverse race of people, but also the opportunity to examine ...
(Date:2/21/2017)... ... February 21, 2017 , ... CLICKco LLC, a company dedicated ... are now available for purchase on RonnieColemanNutrition.com, a popular website for health and ... health-conscious consumers who love coffee but are looking to add more protein to ...
(Date:2/20/2017)... Raton, FL (PRWEB) , ... February 20, 2017 ... ... creating a patent-pending probiotic supplement that supports the proper levels of “good” bacteria ... purchase on StackedNutrition.com, a popular nutritional products website. , Daily Body Restore® ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... 21, 2017 Cognitive Computing for Cancer ... allowing a previously unattainable level of personalized treatment ... ability, it is anticipated that the Global Cancer ... by 2022. The growth of the market is ... platforms, rising installation of cognitive computing software in ...
(Date:2/21/2017)... 2017 Sangamo Therapeutics, Inc. (Nasdaq: SGMO), the ... company will release its fourth quarter and full year ... February 28, 2017. The press release will be followed ... will be open to the public via telephone and ... its financial results and provide a business update. ...
(Date:2/21/2017)... Feb. 21, 2017  International Isotopes Inc. (OTCQB: INIS) ... placement with certain investors for approximately $3.4 million of ... Series C Convertible Redeemable Preferred Stock (the "Series C ... annual rate of 6% and is convertible into common ... use the proceeds for operating capital, to pay off ...
Breaking Medicine Technology: