Navigation Links
Bread mold may hold secret to eliminating disease-causing genes
Date:5/8/2008

COLUMBIA, Mo. When most people discover mold on their bread, they immediately throw it out. Others see a world of possibilities in the tiny fungus. A University of Missouri scientist, along with a collaborative research team, has examined a new mechanism in the reproductive cycle of a certain species of mold. This mechanism protects the organism from genetic abnormalities by silencing unmatched genes during meiosis (sexual reproduction). The finding could have implications for higher organisms and may lead to precise targeting of unwanted genes, such as those from the HIV virus.

Meiotic silencing also occurs in worms, mice and human beings, said Patrick Shiu, assistant professor of biological sciences in the MU College of Arts and Science. Its unlikely that all share the same mechanism, but the principle of targeting unpaired DNA for silencing seems to be found in both simple and complex organisms. Knowing the process of how DNA in molds is targeted for silencing could be important for silencing genes you dont want to be expressed, like disease-causing genes.

Shiu and his colleagues discovered that each sexual cell in mold has an internal mechanism that scans paired chromosomes for anomalies. The researchers found that when one chromosome in a pair carries an extra copy of a gene not found in its partner chromosome, it is a good indication of an intruder and the fungus will turn off all copies of that gene during meiosis. The researchers call this process "meiotic silencing by unpaired DNA, or MSUD.

"MSUD defends the fungus against invasion at a time when chromosomes are especially vulnerable to the spread of viruses and insertion sequences," Shiu said.

Shius research enhances understanding of how to shut off undesirable genes, sheds light on the genetic components of the MSUD pathway, and may have applications in a number of industries, including pharmaceuticals and agriculture.

Because of his contribution to the field of genetics, Shiu recently received the Beadle and Tatum Award, named after Nobel Prize-winning geneticists George Beadle and Edward Tatum. The award was established to recognize outstanding and original research by a scientist using Neurospora, a type of bread mold, as a model organism.


'/>"/>

Contact: Bryan E. Jones
jonesbry@missouri.edu
573-882-9144
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Most Baby Boomers Overestimate Breadth and Depth of Public Safety Net for Disabled Workers
2. Dempsters Smart(TM) 100% Whole Grain Wheat Bread Launched With lifesDHA(TM)
3. New Assessment Highlights Breadth and Depth of Looming Public Health Workforce Crisis
4. Right breakfast bread keeps blood sugar in check all day
5. Secret to Treating Tinnitus in Vets May Be Unlocked in Zebrafish
6. Secretary Cortes Calls Latino Community to Action Against Ailing Health Care System
7. State Health Secretary Visits City of Chester for Cover the Uninsured Week
8. Aspirin-like compounds increase insulin secretion in otherwise healthy obese people
9. Fleeting Facial Expressions Reveal Deep Secrets
10. Seattle-Based Law Firm Williams Kastner Receives Significant Defense Verdict in Trade Secret Business Litigation Case
11. PA Secretary of Public Welfare Releases 2007 Child Abuse Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2017)... , ... February 19, 2017 , ... ProBrand Glitch is a set of 30 glitch ... Glitch users can easily reveal any logo with a glitch reveal in just a few ... over the style and animation of each preset. Use these presets to add a uniquely ...
(Date:2/18/2017)... Church, VA (PRWEB) , ... ... ... Culture of Change for Devicemakers , Sponsored by Axendia, **FDAnews Free Webinar**, ... , Are manufacturers looking to reduce their regulatory burden? Pay dividends ...
(Date:2/18/2017)... ... February 17, 2017 , ... ... , Beverly Hills plastic surgeon Dr. Glenn Vallecillos experiments SculpSure, ... Vallecillos says, "Traditionally, plastic surgery has been centered around that idea that to ...
(Date:2/18/2017)... ... February 18, 2017 , ... ... latest information and contact points to easily connect elderly veterans of America's armed ... and elder-care funding. It also conveys material on this year's increase in the ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... sustainable systems change designed to further positively impact the health and wellness of ... has long considered it our duty to seriously consider releasing our assets beyond ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... , February 20, 2017 ... reach USD 58.4 billion by 2025, according to ... The market is driven by technological advancements in ... growth opportunities to the market. For instance, MediLabSecure, ... aim of identifying emerging viruses and pathogens in ...
(Date:2/20/2017)... , Feb. 20, 2017   Alberty   ... Batavia, NY has announced a significant ... compounding and wellness programs to servicing local Veteran Affairs ... on budgets and an increased need to secure cost ... looking to source locally for their goods & services. ...
(Date:2/19/2017)... 2017   AC Group Inc. , a leading ... vendors in the PMS/EHR healthcare marketplace, will exhibit the ... to succeed in this ecosystem at HIMSS,17. ... obtained from over 200 ACOs, compared and analyzed an ... companies that are providing different pieces of Population Health ...
Breaking Medicine Technology: