Navigation Links
Bread mold may hold secret to eliminating disease-causing genes
Date:5/8/2008

COLUMBIA, Mo. When most people discover mold on their bread, they immediately throw it out. Others see a world of possibilities in the tiny fungus. A University of Missouri scientist, along with a collaborative research team, has examined a new mechanism in the reproductive cycle of a certain species of mold. This mechanism protects the organism from genetic abnormalities by silencing unmatched genes during meiosis (sexual reproduction). The finding could have implications for higher organisms and may lead to precise targeting of unwanted genes, such as those from the HIV virus.

Meiotic silencing also occurs in worms, mice and human beings, said Patrick Shiu, assistant professor of biological sciences in the MU College of Arts and Science. Its unlikely that all share the same mechanism, but the principle of targeting unpaired DNA for silencing seems to be found in both simple and complex organisms. Knowing the process of how DNA in molds is targeted for silencing could be important for silencing genes you dont want to be expressed, like disease-causing genes.

Shiu and his colleagues discovered that each sexual cell in mold has an internal mechanism that scans paired chromosomes for anomalies. The researchers found that when one chromosome in a pair carries an extra copy of a gene not found in its partner chromosome, it is a good indication of an intruder and the fungus will turn off all copies of that gene during meiosis. The researchers call this process "meiotic silencing by unpaired DNA, or MSUD.

"MSUD defends the fungus against invasion at a time when chromosomes are especially vulnerable to the spread of viruses and insertion sequences," Shiu said.

Shius research enhances understanding of how to shut off undesirable genes, sheds light on the genetic components of the MSUD pathway, and may have applications in a number of industries, including pharmaceuticals and agriculture.

Because of his contribution to the field of genetics, Shiu recently received the Beadle and Tatum Award, named after Nobel Prize-winning geneticists George Beadle and Edward Tatum. The award was established to recognize outstanding and original research by a scientist using Neurospora, a type of bread mold, as a model organism.


'/>"/>

Contact: Bryan E. Jones
jonesbry@missouri.edu
573-882-9144
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Most Baby Boomers Overestimate Breadth and Depth of Public Safety Net for Disabled Workers
2. Dempsters Smart(TM) 100% Whole Grain Wheat Bread Launched With lifesDHA(TM)
3. New Assessment Highlights Breadth and Depth of Looming Public Health Workforce Crisis
4. Right breakfast bread keeps blood sugar in check all day
5. Secret to Treating Tinnitus in Vets May Be Unlocked in Zebrafish
6. Secretary Cortes Calls Latino Community to Action Against Ailing Health Care System
7. State Health Secretary Visits City of Chester for Cover the Uninsured Week
8. Aspirin-like compounds increase insulin secretion in otherwise healthy obese people
9. Fleeting Facial Expressions Reveal Deep Secrets
10. Seattle-Based Law Firm Williams Kastner Receives Significant Defense Verdict in Trade Secret Business Litigation Case
11. PA Secretary of Public Welfare Releases 2007 Child Abuse Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... D.C. (PRWEB) , ... April 28, 2016 , ... USA Medical Card reminds us that ... Prevention (CDC), a stroke is the fourth leading cause of death in the United States; ... with almost a quarter of them in individuals under 65 years old. A stroke ...
(Date:4/28/2016)... ... 2016 , ... Point Source Audio® (PSA) , an ... today that the US Patent Office has approved its patent submission that covers ... design creates a lightweight and modular audio headset that has been said to ...
(Date:4/28/2016)... Cary, NC (PRWEB) , ... April 28, 2016 ... ... to announce it has partnered with Community Oncology Pharmacy Association (COPA) to develop ... elevate the practice of oncology by introducing an accreditation distinction. ACHC provides a ...
(Date:4/28/2016)... , ... April 28, 2016 , ... ... Pharmacy Discount Cards in the mail from USA Medical Prescription Assistance Program. They ... , Each mailed package will include a ready-to-use, state-themed card and, ...
(Date:4/28/2016)... ... April 28, 2016 , ... For the 10,000 Americans who turn ... an important part of overall well-being: mental health. Now, a new book—Staying Sharp For ... aging and “cognitive vitality,” which can include everything from honing your memory and managing ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... -- Research and Markets has announced the ... 2016-2020" report to their offering.      ... global plastic surgery products market is expected to grow ... , ,The growing adoption of laser in aesthetics is ... market. Lasers are used to treat a broad range ...
(Date:4/28/2016)... 28, 2016  The blood testing market in ... to Kalorama Information and The Freedonia Group in a ... acid testing.  The healthcare research firm said that ... blood collection stations and in improving testing at the ... report, Blood Testing Market in China ...
(Date:4/28/2016)... April 28, 2016 Dr. Vivek ... and Ste phen Schmidt ... a leading provider of cloud-based software solutions for life sciences, today ... to bring a wealth of insight to a growing business.  This ... George Phillips joined ArisGlobal in the position ...
Breaking Medicine Technology: