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Brandeis scientist invents anti-cholesterol process
Date:6/18/2013

Senior Brandeis research scientist Daniel Perlman has discovered a way to make phytosterol molecules from plants dispersible in beverages and foods that are consumed by humans, potentially opening the way to dramatic reductions in human cholesterol levels.

A U.S. patent (#8,460,738) on the new process and composition was issued on June 11.

Phytosterols in plants and cholesterol molecules in animals are highly similar and when both are dispersed together they are attracted to one another. When they mix in the gut of an animal, the cholesterol molecules are competitively inhibited from passing into the blood stream and instead are excreted.

The ability of phytosterols to reduce cholesterol levels in animals has been recognized since the 1950s, but practical application of this knowledge was difficult because phytosterols are not naturally water-soluble, and they are only poorly soluble in fatty substances.

Perlman and K.C. Hayes, professor emeritus of biology and former director of the Foster Biomedical Research Laboratories, invented and patented a way to increase the bioavailability of phytosterols in fats more than 10 years ago. Their separate discoveries relating to fat metabolism and oxidative stability led to development of the Smart Balance blend of oils and a number of other food products.

However, improving dispersal of phytosterols in water has remained problematic, and was an obstacle to their general use in foods and beverages. Phytosterols placed in water-based substances will not disperse, and this has thwarted their cholesterol-reducing potential.

Now, Perlman has found a way to change the behavior of phytosterols in liquids by forming a new complex in which glycerin molecules attach to phytosterol molecules. Phytosterols and glycerin are heated together to a temperature at which the water molecule that usually attaches to each phytosterol molecule boils off and is replaced by a glycerin m
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Contact: Charles A. Radin
radin@brandeis.edu
781-736-4210
Brandeis University
Source:Eurekalert

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