Navigation Links
Brandeis scientist invents anti-cholesterol process
Date:6/18/2013

Senior Brandeis research scientist Daniel Perlman has discovered a way to make phytosterol molecules from plants dispersible in beverages and foods that are consumed by humans, potentially opening the way to dramatic reductions in human cholesterol levels.

A U.S. patent (#8,460,738) on the new process and composition was issued on June 11.

Phytosterols in plants and cholesterol molecules in animals are highly similar and when both are dispersed together they are attracted to one another. When they mix in the gut of an animal, the cholesterol molecules are competitively inhibited from passing into the blood stream and instead are excreted.

The ability of phytosterols to reduce cholesterol levels in animals has been recognized since the 1950s, but practical application of this knowledge was difficult because phytosterols are not naturally water-soluble, and they are only poorly soluble in fatty substances.

Perlman and K.C. Hayes, professor emeritus of biology and former director of the Foster Biomedical Research Laboratories, invented and patented a way to increase the bioavailability of phytosterols in fats more than 10 years ago. Their separate discoveries relating to fat metabolism and oxidative stability led to development of the Smart Balance blend of oils and a number of other food products.

However, improving dispersal of phytosterols in water has remained problematic, and was an obstacle to their general use in foods and beverages. Phytosterols placed in water-based substances will not disperse, and this has thwarted their cholesterol-reducing potential.

Now, Perlman has found a way to change the behavior of phytosterols in liquids by forming a new complex in which glycerin molecules attach to phytosterol molecules. Phytosterols and glycerin are heated together to a temperature at which the water molecule that usually attaches to each phytosterol molecule boils off and is replaced by a glycerin molecule. Because glycerin molecules have multiple places at which water molecules can be attached and because glycerin also inhibits crystal growth that complicates dispersal, the phytosterol-glycerin complex together with an emulsifier becomes dispersible in water-based foods.

"I had been playing with ideas on how to enhance the dispersibility of this molecule for a number of years," said Perlman, who has more than 100 patents and pending patents on inventions he has made in his years at Brandeis. This was critically important, he explained, because "if you really want to have widespread public health benefits, you want to be able to put [phytosterols] in foods and beverages."

Hayes said he has tested Perlman's new compound on gerbils in his laboratory and obtained results from the water-dispersed phytosterols that are excellent in terms of their cholesterol-reducing action.

Physics Professor Seth Fraden, who is director of the Brandeis Materials Research Science and Engineering Center, said "the actual science of how it all works" when the attachment of glycerin changes phytosterol behavior "is not understood."

Perlman, he said, "had a chemical intuition for doing this. He is a good chemist; he has a feeling for molecules and what they'll do when you mix them. In addition to this intuition, he is very open-minded and will go in the lab and try things that other people don't do because their professors have told them it won't work.

"That's why he's a good inventor," Fraden said.


'/>"/>

Contact: Charles A. Radin
radin@brandeis.edu
781-736-4210
Brandeis University
Source:Eurekalert

Related medicine news :

1. Scientists at UMass Medical School identify neurons that control feeding behavior in Drosophila
2. Scientists ID Gene Behind Early Onset Puberty
3. NIH scientists discover how HIV kills immune cells
4. Scientists find potential new clues for identifying breast cancer risk
5. PolyU Scientists Help Identify Genes Causing Myopia
6. Scientists Gauge Radiation Dose From Trip to Mars
7. Scientists Spot Genes Tied to Success at School, College
8. German and Israeli scientists gain new insights into protein disposal
9. Scientists Cant Replicate Surprising Finding on Alzheimers Treatment
10. Scientists discover how rapamycin slows cell growth
11. Scientists Map the Fungi on Your Feet
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... technology to revolutionize the emergency ambulance transport experience for the millions of people ... how Uber has disrupted the taxi industry through the use of technology. Now, ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A ... 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the ... history as home to some of the world’s leading providers of cereal and other ...
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... 25, 2016 , ... Austin residents seeking Mohs surgery services, can now turn ... to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization ... selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
(Date:6/23/2016)... -- Any dentist who has made an implant supported denture ... of them do not even offer this as a viable ... costs involved. And those who ARE able to offer that ... cost that the majority of today,s patients would not be ... , founder of Dental Evolutions Inc. and inventor of Implanova ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
Breaking Medicine Technology: