Navigation Links
Brainstem discovered as important relay site after stroke
Date:2/25/2014

Around 16,000 people in Switzerland suffer a stroke every year. Often the result of a sudden occlusion of a vessel supplying the brain, it is the most frequent live-threatening neurological disorder. In most cases, it has far-reaching consequences for survivors. Often the stroke sufferers have to cope with handicaps and rehabilitation is a long process. The brain does, however, have a "considerable capacity for regeneration" explains Lukas Bachmann from the Brain Research Institute of the University of Zurich. As member of Professor Martin Schwab's research team, he found that the brainstem, the oldest region in the brain, could play an important role in recovery. The results have now been published in "The Journal of Neuroscience".

The healthy half of the brain assumes control

A stroke in the cerebral cortex frequently leads to motor constraints of one half of the body, to what is known as hemiparesis. This is due to the loss of neuron pathways which transmit signals from the cortex to the spinal cord. As these pathways are crossed, the side of the body contralateral to the affected half of the brain is affected. The major impairments at the beginning are often only temporary and stroke sufferers can sometimes stage an amazing recovery. "The side of the body affected is increasingly controlled by the ipsilateral side of the cortex, i.e. the healthy side", explains Lukas Bachmann. As the neuron pathways are crossed, this raised the following question for the neuroscientists: by which pathway are the signals rerouted from the motor cortex to the ipsilateral parts of the spinal cord?

Sprouting of neurons from the brainstem

In their study in mice the researchers in Martin Schwab's team now demonstrate that the brainstem probably plays a key role in the rerouting of neural impulses. Images of the brain show that after a major stroke nerve fibers from specific core regions of the brain sprout into the area of the spinal cord that had lost its input after a stroke. "At the same time, more fibers sprout from the intact cortex into these same regions of the brainstem", continues Lukas Bachmann. These changes in the neuronal circuits may mediate the non-crossed flow of nerve impulses after a stroke. "This could turn out to be a key mechanism which facilitates recovery after a stroke", says the brain researcher. The scientists now want to use these findings to steer the sprouting of neurons in various areas of the brain by means of targeted therapy to maximise the recovery of motor functions.


'/>"/>

Contact: Dr. Lukas C. Bachmann
bachmann@hifo.uzh.ch
41-446-353-261
University of Zurich
Source:Eurekalert

Related medicine news :

1. Critical protein discovered for healthy cell growth in mammals
2. Molecule discovered that protects the brain from cannabis intoxication
3. CU researchers may have discovered a plan to disable Menieres disease
4. Newly discovered brown fat cells hold possibilities for treating diabetes, obesity
5. Discovered a mechanism that induces migration of tumor cells in liver cancer
6. 11 new genetic susceptibility factors for AD discovered through the largest study
7. Newly discovered weakness in cancer cells make them more susceptible to chemotherapy
8. Cell memory mechanism discovered
9. Pedata RV Center Warns of Plagued Squirrels Discovered in San Diego Area
10. Second door discovered in war against mosquito-borne diseases
11. Bellovin & Karnas, P.C. in Arizona Investigate after Hepatitis A Tainted Berries Are Discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2017)... ... ... “Squiggy’s Outdoor Adventure”: a turtle’s backyard adventure that teaches the importance of ... Christian, a wife and mother to three amazing, and supportive, children. Paula lives ... God. She loves to tell stories to her children, play board games, bake, ...
(Date:7/22/2017)... ... July 22, 2017 , ... The arthroscopic superior ... the opportunity to return to sports and jobs that require heavy physical work, ... Medicine’s Annual Meeting in Toronto, Ontario, Canada. , “We studied 100 ...
(Date:7/21/2017)... Augusta, GA (PRWEB) , ... July 21, 2017 , ... ... is teaming up with the Epilepsy Foundation in a community wide charity event with ... region. , Delaney Sunde, a young local woman who lives with epilepsy, recently launched ...
(Date:7/21/2017)... ... , ... Fresh Wave® IAQ today announced the launch of its innovative ... at the APPA 2017 Annual Conference and Exhibition in Booth #414. , ... the use of harsh chemicals, Fresh Wave IAQ Smoke Away Air & Fabric Liquid ...
(Date:7/21/2017)... ... ... Margarian Law Firm has filed a class action lawsuit against Dr. Pepper ... Dr. Pepper produces the “Canada Dry” brand of ginger ale products. In Gegham Margaryan ... claims on its bottle that it is made from real ginger. , When consumers ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... 10, 2017  BDI Group subsidiary Pathway Purchasing ... services organization serving specialty pharmacies, home infusion companies ... four significant, value-added member programs designed to help ... reimbursement and improve access and affordability for patients ... Pathway has ...
(Date:7/6/2017)... 6, 2017 ThriveRx, the nutrition division of Diplomat Specialty Infusion ... thrive on nutrition support. To celebrate its anniversary, ThriveRx recently ... a fresh new look with improved organization to create the best user ... ... "We,ve made several ...
(Date:7/5/2017)... company of over 2,000 employees and a leader in environmental and life science ... their position as the top American owned and operated environmental testing firm in ... ... ... , enhances Pace Analytical,s capability as an innovative full service provider in ...
Breaking Medicine Technology: