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Brains of Fetuses 'Build a Bridge' Between Regions, Images Show
Date:2/20/2013

By Maureen Salamon
HealthDay Reporter

WEDNESDAY, Feb. 20 (HealthDay News) -- Using real-time images of brain connections developing in late-stage fetuses, scientists say they've been able for the first time to compare the order and strength of these connections.

The research, though very preliminary, might one day lead the way to more effective therapies for brain disorders such as dyslexia, attention-deficit/hyperactivity disorder (ADHD) and autism, the researchers said.

Scientists from the U.S. National Institute of Child Health and Human Development and Wayne State University School of Medicine looked at 25 fetal brains from a group of pregnant women between 24 and 38 weeks of gestation. The researchers used an imaging technique called functional MRI (fMRI) to visualize "communication" between various regions of the brain.

The scientists learned that connections between the right and left sides of the brains got stronger as fetuses grew older. They said they also learned that shorter distances between matching areas produced stronger signals than longer spans between corresponding areas on the brain's outer edges.

"What we're seeing is a picture of emerging connectivity . . . that the right and left side are kind of building a bridge to each other," said study author Moriah Thomason, an assistant professor of pediatrics at Wayne State, in Detroit. "It's evidence for the fact that already in fetal life, this anatomy is being constructed in a way that we would expect. But for the first time, we can show the development of these networks."

The findings are published in the Feb. 20 issue of the journal Science Translational Medicine.

While scientists had previously used fMRI scans on fetuses, this new research is the first to compare a group of fetuses and identify features of development, Thomason said. Nearly 90 percent of the pregnant mothers participating in the study were black,
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