Navigation Links
Brain's master switch is verified by Iowa State University researcher
Date:5/7/2010

AMES, IA - The protein that has long been suspected by scientists of being the master switch allowing brains to function has now been verified by an Iowa State University researcher.

Yeon-Kyun Shin, professor of biochemistry, biophysics and molecular biology at ISU, has shown that the protein called synaptotagmin1 (Syt1) is the sole trigger for the release of neurotransmitters in the brain.

Prior to this research, Syt1 was thought to be a part of the protein structure (not the sole protein) that triggered the release of neurotransmitters at 10 parts per million of calcium.

Shin's research is published in the current issue of the journal Science.

"Syt1 was a suspect previously, but people were not able to pinpoint that it's the real one, even though there were lots and lots of different trials," said Shin.

"In this case, we are trying to show in the laboratory that it's the real one. So we excluded everything else, and included SNARE proteins -- that's the machinery of the release, and the Syt1 is a calcium-sensing timer."

Syt1 senses, at 10 ppm of calcium, and tells the SNARE complex to open the pore to allow the movement of the neurotransmitters.

Brain activity occurs when neurotransmitters move into a fusion pore.

"We are showing that this Syt1 senses the calcium at 10 ppm, and sends the signal to the SNARE complex to open the fusion pore. That is the process that we are showing right now," Shin said.

Shin and his researchers were able to pinpoint the protein using a new technique called single vesicle fusion method. Using this method, they were able to create and monitor a single fusion event.

Previous research didn't allow scientists to look at single events, and instead required detecting many events and then taking an average of those events, Shin says.

Shin, who has been looking at this brain activity for 15 years, is happy about the discovery.

"We are quite excited that for the first time we are showing that Syt1 is really what triggers the signal in the brain," he said. "This is a really important thing in terms of neurosciences. This is the heart of the molecular part of the brain function."

Shin believes his discovery may be useful in understanding brain malfunctions such as autism, epilepsy and others.

While researching brain function, Shin has previously shown that taking statin drugs to lower cholesterol may actually inhibit some brain function.


'/>"/>

Contact: Yeon-Kyun Shin
colishin@iastate.edu
515-294-2530
Iowa State University
Source:Eurekalert  

Related medicine news :

1. SKyPRO Releases Public Beta of GWTalk at BrainShare
2. Morphine May Protect Brains of People With HIV
3. SharpBrains Launches First Brain Fitness Innovation Awards to Recognize Neuroplasticity Pioneers
4. Scientists Tweak Subjects Brains to Alter Their Moral Choices
5. MessageSolution First in the Market to Offer All-in-One, Integrated Cloud-Based Archiving for Email, File Systems and SharePoint at Novell BrainShare 2010
6. iPhone Memory Aid for Scatterbrains, Aging Baby Boomers and Busy, Forgetful People
7. Pro Athletes Brains React at Olympic Speed
8. Older brains make good use of useless information
9. First Global, Virtual Summit on Cognitive Health and Performance Features 200 Sharp Brains
10. Woodmeister Master Builders Announces Commitment to Preserve One Foot of Forest for Each Foot it Builds
11. Green-Buildings.com Launches LEED Green Associate Master Program
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Brain's master switch is verified by Iowa State University researcher
(Date:3/27/2017)... ... March 27, 2017 , ... According to the American ... all stages, is more than 95%. Once the cancer spreads to other organs, bones, ... To find out how to avoid this latter group, tune in to Lifestyle ...
(Date:3/27/2017)... Angel, Oregon (PRWEB) , ... March 27, 2017 ... ... company, is pleased to announce the launch of a months-long rebranding effort. This ... new formulations. , “Through focus group discussions and market research, we learned that ...
(Date:3/27/2017)... ... March 27, 2017 , ... From 1999 to 2015, the ... over 33,000 of the 52,404 drug-related deaths in 2015.(2) To combat the growing ... a tax on prescription opioids to fund drug rehabilitation and prevention services.(3) ...
(Date:3/26/2017)... , ... March 26, 2017 , ... ... to receive the RealSelf 100 Award, a prestigious award honoring the top influencers ... and to find and connect with doctors and clinics. , In 2016, more ...
(Date:3/24/2017)... ... March 24, 2017 , ... Clean Earth, Inc., a leader ... and non-hazardous materials announced today the acquisition of privately owned AERC Recycling ... additional processing facilities and a vast array of additional technologies, services, and new ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... 27, 2017  Twist Bioscience, a company accelerating science ... that it raised an additional $33 million. To date, ... "It is an exciting time to ... and continue to deliver industry-leading gene volume to our ... Emily M. Leproust, Ph.D., CEO of Twist Bioscience. "We ...
(Date:3/27/2017)... 2017 Arena Pharmaceuticals, Inc. (NASDAQ: ... small molecule drugs across multiple therapeutic areas, today announced that ... will present a corporate update at the 16th Annual Needham ... conference will take place April 4-5, 2017 at the Westin ... , NY.  A live audio webcast of ...
(Date:3/24/2017)... 24, 2017 New England Pediatric Device Consortium ... award including funding and in-kind service towards the commercialization ... "Making blood draws less traumatic for children ... hospital experience better.  We,re looking forward to working with ... improve care for the kids we treat," said ...
Breaking Medicine Technology: