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Brain tumor cells penetrated by tiny, degradable particles carrying genetic instructions
Date:4/29/2014

n this case at causing cell death in the brain cancer cells (up to 97 percent effective) than in the non-cancerous cells (0 to 27 percent, depending on nanoparticle type).

Green emphasizes that for nanoparticle-based genetic therapies that are safe for patients, the specific siRNA or DNA being delivered in a clinical treatment would be carefully chosen so that, even if there was off-target delivery to healthy cells, it would only be detrimental to cancer cells. Green is encouraged by the results so far. "Combining what we've learned in these two studies, we might even be able to design particles that can deliver DNA and siRNA at the same time," he says. "That would allow us to fine tune the genetic self-destruct code that our particles deliver so that cancer cells die and healthy cells do not."

"Dr. Green and his colleagues have taken important steps in developing polymeric nanoparticles for DNA and siRNA delivery, with promising specificity for tumor cells and enhanced stability," said Jessica Tucker, Ph.D., program director for drug and gene delivery systems and devices at the National Institute of Biomedical Imaging and Bioengineering, which provided partial funding for these studies. "Though many challenges still remain, such work could potentially transform treatment outcomes for patients with glioblastoma and related brain tumors, for which current therapies provide limited benefits."


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Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

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