Navigation Links
Brain tumor cells penetrated by tiny, degradable particles carrying genetic instructions
Date:4/29/2014

Working together, Johns Hopkins biomedical engineers and neurosurgeons report that they have created tiny, biodegradable "nanoparticles" able to carry DNA to brain cancer cells in mice.

The team says the results of their proof of principle experiment suggest that such particles loaded with "death genes" might one day be given to brain cancer patients during neurosurgery to selectively kill off any remaining tumor cells without damaging normal brain tissue.

A summary of the research results appeared online on April 26 in the journal ACS Nano.

"In our experiments, our nanoparticles successfully delivered a test gene to brain cancer cells in mice, where it was then turned on," says Jordan Green, Ph.D., an assistant professor of biomedical engineering and neurosurgery at the Johns Hopkins University School of Medicine. "We now have evidence that these tiny Trojan horses will also be able to carry genes that selectively induce death in cancer cells, while leaving healthy cells healthy."

Green and his colleagues focused on glioblastomas, the most lethal and aggressive form of brain cancer. With standard treatments of surgery, chemotherapy and radiation, the median survival time is only 14.6 months, and improvement will only come with the ability to kill tumor cells resistant to standard treatments, according to Alfredo Quiones-Hinojosa, M.D., a professor of neurosurgery at the Johns Hopkins University School of Medicine and a member of the research team.

Because nature protects the brain by making it difficult to reach its cells through the blood, efforts turned to the use of particles that could carry tumor-destroying DNA instructions directly to cancer cells during surgery.

The initial experiments made use of cancer cells that Quiones-Hinojosa and his team removed from willing patients and grew in the laboratory until they formed little spheres of cells, termed oncospheres, likely to be the most resistan
'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Stroke risk reduced if brain blood vessel disorder is left alone
2. Diabetes duration and severity associated with brain atrophy
3. Precise brain mapping can improve response to deep brain stimulation in depression
4. Stanford scientists create circuit board modeled on the human brain
5. Study finds almost half of homeless men had traumatic brain injury in their life
6. Study finds almost half of homeless men had traumatic brain injury in their
7. Inaugural Brain Health Summit focuses on brain resilience and regeneration
8. Breast cancer replicates brain development process
9. Newly approved brain stimulator offers hope for individuals with uncontrolled epilepsy
10. Brain size matters when it comes to animal self-control
11. Sleep disorder linked to brain disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Brain tumor cells penetrated by tiny, degradable particles carrying genetic instructions
(Date:7/28/2014)... Parker Waichman LLP, a personal injury law firm ... heroes of 9/11 are never forgotten, comments that the September ... According to a VCF message dated July 3, ... or before October 12, 2012 must file a Registration Form ... who were allegedly injured by the toxic dust cloud that ...
(Date:7/28/2014)... 28, 2014 The Brooke Jackman ... donated more than 200,000 books to children and families ... launch of Brooke’s Cooks, a new initiative designed to ... living among at-risk children and their families in the ... series of nutrition information workshops, cooking demonstrations and readings. ...
(Date:7/28/2014)... 28, 2014 Bariatric Eating, a leading ... that it will be introducing three additional flavors to ... summer. The additional flavors include: , Inspire Summer Melon ... , Inspire Pomegranate Razz Berry -­ Pomegranate, razz and ... vanilla cone , Bariatric Eating's Inspire protein powders ...
(Date:7/28/2014)... Stimulating one of two dopamine-producing regions in the brain ... either isoflurane or propofol. In the August issue ... (MGH) report that rats anesthetized with continuous doses of ... stand up in response to electrical stimulation delivered to ... other major dopamine-releasing area, the substantia nigra, did not ...
(Date:7/28/2014)... York, New York (PRWEB) July 28, 2014 ... the long-acting birth control device caused some users to ... proper position in the uterus continue to mount in ... a new case list issued last month in New ... are pending in a multicounty litigation underway in Bergen ...
Breaking Medicine News(10 mins):Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 2Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 4Health News:Bariatric Eating Announces Three New Protein Shake Flavors 2Health News:Stimulation of brain region restores consciousness to animals under general anesthesia 2Health News:Mirena IUD Lawsuit Filings Exceed 920 in New Jersey Litigation, Bernstein Liebhard LLP Reports 2Health News:Mirena IUD Lawsuit Filings Exceed 920 in New Jersey Litigation, Bernstein Liebhard LLP Reports 3Health News:Mirena IUD Lawsuit Filings Exceed 920 in New Jersey Litigation, Bernstein Liebhard LLP Reports 4
... the Ontario Government to launch a programme to ensure ... sexual assault, who might have been exposed to the ... treatment ($1,200) has resulted in a limited availability of ... ,Very little effort is being done to ...
... taking their example from movies, and starting to experiment with ... has measured the influence of alcohol use in movies and, ... found that movies play a significant role in an adolescent's ... ,The regional study was published in the January issue of ...
... Mohan Rai, the Health Minister of the Indian State of Bihar ... will be introduced// in the state. An annual premium of Rs ... five members. This will serve to provide the family with free ... live below the poverty line will receive the benefits without having ...
... rural areas have to undertake long treks to receive medical ... ,Nine per cent of all physicians in Canada worked in ... of the population, according to a report issued by the ... from the mid-1990s, despite a wide variety of strategies implemented ...
... therapy is being provided to people who wish to give ... are over the age of 18 years// will benefit from ... Treatment for Ontario Patients (STOP) Study, which will also provide ... to which quitting method is more effective, according to Center ...
... to replace the conventional Pap smear was proved that it ... of the liquid-based// cytology (LBC), was introduced across Scotland. ... not more reliable than the older one. ,The ... probe inside the issue. But he said till now this ...
Cached Medicine News:Health News:Reach Of The Morning-After Pill Treatment Inadequate Among Sexual Assault Victims 2Health News:Rural Canadians travel far for specialists: study 2
(Date:7/28/2014)... HONG KONG , July 28, 2014  Syneron ... global aesthetic device company, announced today that its new ... tattoos of all types and colors and pigmented lesions ... innovative dual wavelength device, with 532nm and 1064nm wavelengths, ... to the skin using pulses which are trillionths of ...
(Date:7/28/2014)... July 28, 2014  ResMed (NYSE: RMD ... the treatment of sleep-disordered breathing and other chronic respiratory ... Germany against Taiwanese medical device manufacturer APEX ... on APEX WiZARD 210 and 220 masks.  The judgment ... Munich , is appealable, and applies throughout ...
(Date:7/28/2014)... and NEW PROVIDENCE, N.J. ... engineering professionals are invited to meet with Linde,s Healthcare ... Technical Exhibition to be held at McCormick Place in ... "Hospitals demand nothing less than complete ... Mark Sanda , Linde,s Healthcare Segment manager. "Linde understands ...
Breaking Medicine Technology:Syneron Announces CE Mark for PicoWay Dual Wavelength Picosecond Laser for Tattoo Removal and Treatment of Pigmented Lesions 2Syneron Announces CE Mark for PicoWay Dual Wavelength Picosecond Laser for Tattoo Removal and Treatment of Pigmented Lesions 3Syneron Announces CE Mark for PicoWay Dual Wavelength Picosecond Laser for Tattoo Removal and Treatment of Pigmented Lesions 4ResMed Receives Permanent Injunction against APEX in Germany, Continues Enforcement of Patents in Europe 2Linde's Healthcare division to display new Hospital Services platform at the national ASHE Conference in Chicago 2
Aplicare's disposable 1-ounce pouches are designed for individual application and are ideal for reducing waste. They are used in nursing homes, home healthcare settings, blood banks, laboratories, em...
... a gentle and effective surgical scrub with ... Iodine is known to kill skin surface ... viruses, protozoa and yeasts. It produces a ... patient pre-operative prepping, as well as for ...
... is appropriate for pre-surgical patient preparation ... spray); disinfecting of wounds and burns; ... and abrasions. It also acts as ... and office procedures, providing protection against ...
Pre-Saturated Sponge Sticks...
Medicine Products: