Navigation Links
Brain tumor cells killed by anti-nausea drug
Date:3/19/2013

New research from the University of Adelaide has shown for the first time that the growth of brain tumors can be halted by a drug currently being used to help patients recover from the side effects of chemotherapy.

The discovery has been made during a study looking at the relationship between brain tumors and a peptide associated with inflammation in the brain, called "substance P".

Substance P is commonly released throughout the body by the nervous system, and contributes to tissue swelling following injury. In the brain, levels of substance P greatly increase after traumatic brain injury and stroke.

"Researchers have known for some time that levels of substance P are also greatly increased in different tumor types around the body," says Dr Elizabeth Harford-Wright, a postdoctoral fellow in the University's Adelaide Centre for Neuroscience Research.

"We wanted to know if these elevated levels of the peptide were also present in brain tumor cells, and if so, whether or not they were affecting tumor growth. Importantly, we wanted to see if we could stop tumor growth by blocking substance P."

In laboratory studies for her PhD, Dr Harford-Wright found that levels of substance P were greatly increased in brain tumor tissue.

Knowing that substance P binds to a receptor called NK1, Dr Harford-Wright used an antagonist drug called Emend to stop substance P binding to the receptor. Emend is already used in cancer clinics to help patients with chemotherapy-induced nausea.

The results were startling.

"We were successful in blocking substance P from binding to the NK1 receptor, which resulted in a reduction in brain tumor growth and it also caused cell death in the tumor cells," Dr Harford-Wright says.

"So preventing the actions of substance P from carrying out its role in brain tumors actually halted the growth of brain cancer.

"This is a very exciting result, and it offers further opportunities to study possible brain tumor treatments over the coming years."


'/>"/>

Contact: Dr Elizabeth Harford-Wright, University of Adelaide
elizabeth.harfordwright@adelaide.edu.au
61-883-134-261
University of Adelaide
Source:Eurekalert

Related medicine news :

1. Immortality gene mutation identifies brain tumors and other cancers
2. Similar neuro outcomes in preterm infants with low-grade brain bleeding as infants with no bleeding
3. Univ. of MD School of Medicine finds depression stems from miscommunication between brain cells
4. Penn research shows that suppressing the brains filter can improve performance in creative tasks
5. Outside the box: UCLA uses brain aneurysm treatment to stop irregular heart rhythms
6. Study: Dynamic new software improves care of aging brain
7. New early warning system for the brain development of babies published in video journal
8. Brain researcher James Poulet receives the 2013 Paul Ehrlich Prize for Young Researchers
9. Brain stent offers alternative to shunt for fixing potentially blinding vein narrowing
10. Certain Men May Face Higher Risk of Brain Injury
11. Bradley Hospital researchers find age-related changes in how autism affects the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... “The Communion of Saints: A ... God in congregations across the United States. “The Communion of Saints” is ... who has served congregations in seven states throughout his long career of devotion ...
(Date:3/23/2017)... ... 23, 2017 , ... In 2016 the World Health Organization declared the Zika ... million Zika-related cases in the Americas within the next year. Lyme disease is one ... year skyrocketing to an estimated 329,000. Yet, Zika, Lyme and other insect borne illnesses ...
(Date:3/23/2017)... ... ... The physicians of KSF Orthopaedic Center PA are proud to announce the opening ... at 2255 E. Mossy Oaks Rd., Suite 440, Spring, Texas 77389 inside the new ... in the north Houston area (The Woodlands, Conroe, Magnolia, Kingwood, Humble) with an even ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... Texas ... located at 960 Gruene Road in Building 2. The clinic is the group’s second ... Bennett, PT, says opening the company’s second New Braunfels location brings things full circle ...
(Date:3/23/2017)... ... ... The IoT (Internet of Things) is revolutionizing the way the world operates. ... and individual consumers alike. Laboratories can maximize their profit margin by increasing throughput. ... trillion to $11 trillion dollars by the year 2025. McKinsey expects the IoT to ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , March 23, 2017  Mirabilis Medical, ... advanced medical technology for non-invasive surgery, announced today ... System for treatment of uterine fibroids throughout the ... had received approval from the US Food and ... the Mirabilis System in the United States.  The ...
(Date:3/23/2017)... Care, based in St. Joseph, Missouri , has selected AccuReg to ... located in 22 cities, and its flagship St. Joseph Medical Center. Mosaic ... health care to its patients, including the insurance, billing and collections processes. ... ... Care St. Joseph Medical Center ...
(Date:3/23/2017)... and INDIANAPOLIS , March ... LLY ) and the William Sansum Diabetes Center ... of Latino people affected by diabetes through enhanced research, ... of diabetes and cardiovascular disease bears a disproportionate weight ... ," said David Kerr , M.D., FRCPE, ...
Breaking Medicine Technology: