Navigation Links
Brain tumor cells killed by anti-nausea drug

New research from the University of Adelaide has shown for the first time that the growth of brain tumors can be halted by a drug currently being used to help patients recover from the side effects of chemotherapy.

The discovery has been made during a study looking at the relationship between brain tumors and a peptide associated with inflammation in the brain, called "substance P".

Substance P is commonly released throughout the body by the nervous system, and contributes to tissue swelling following injury. In the brain, levels of substance P greatly increase after traumatic brain injury and stroke.

"Researchers have known for some time that levels of substance P are also greatly increased in different tumor types around the body," says Dr Elizabeth Harford-Wright, a postdoctoral fellow in the University's Adelaide Centre for Neuroscience Research.

"We wanted to know if these elevated levels of the peptide were also present in brain tumor cells, and if so, whether or not they were affecting tumor growth. Importantly, we wanted to see if we could stop tumor growth by blocking substance P."

In laboratory studies for her PhD, Dr Harford-Wright found that levels of substance P were greatly increased in brain tumor tissue.

Knowing that substance P binds to a receptor called NK1, Dr Harford-Wright used an antagonist drug called Emend to stop substance P binding to the receptor. Emend is already used in cancer clinics to help patients with chemotherapy-induced nausea.

The results were startling.

"We were successful in blocking substance P from binding to the NK1 receptor, which resulted in a reduction in brain tumor growth and it also caused cell death in the tumor cells," Dr Harford-Wright says.

"So preventing the actions of substance P from carrying out its role in brain tumors actually halted the growth of brain cancer.

"This is a very exciting result, and it offers further opportunities to study possible brain tumor treatments over the coming years."


Contact: Dr Elizabeth Harford-Wright, University of Adelaide
University of Adelaide

Related medicine news :

1. Immortality gene mutation identifies brain tumors and other cancers
2. Similar neuro outcomes in preterm infants with low-grade brain bleeding as infants with no bleeding
3. Univ. of MD School of Medicine finds depression stems from miscommunication between brain cells
4. Penn research shows that suppressing the brains filter can improve performance in creative tasks
5. Outside the box: UCLA uses brain aneurysm treatment to stop irregular heart rhythms
6. Study: Dynamic new software improves care of aging brain
7. New early warning system for the brain development of babies published in video journal
8. Brain researcher James Poulet receives the 2013 Paul Ehrlich Prize for Young Researchers
9. Brain stent offers alternative to shunt for fixing potentially blinding vein narrowing
10. Certain Men May Face Higher Risk of Brain Injury
11. Bradley Hospital researchers find age-related changes in how autism affects the brain
Post Your Comments:
(Date:10/13/2015)... Dallas, Texas (PRWEB) , ... October 13, 2015 ... ... network headquartered in McHenry County, Illinois with more than 59,000 emergency department visits ... department information system (EDIS) from T-System, to help improve clinical, operational and financial ...
(Date:10/13/2015)... ... ... Tempe Dental Care, a leading Tempe dentists’ office, celebrates offering gentle, pain free sedation ... than 5 years. A leading cause of emergency room visits, school absences, and missed ... , Sedation dentistry provides an anxiety-free dental experience with safe and ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... World ... Driveway Snow Blanket, a snow melting invention that helps people in clearing snow away ... and will continue to grow at 3.8% per year," says Scott Cooper, CEO and ...
(Date:10/13/2015)... ... 13, 2015 , ... According to an ESPN report published on ... teammate accidentally elbowed him in the left eye during the first day of practice ... of a series of setbacks, including a knee injury that has interfered with his ...
(Date:10/13/2015)... ... October 13, 2015 , ... Thermi, an award-winning and ... to introduce the latest development, ThermiVa® temperature controlled radiofrequency to the medical community. ... Obstetrics and Gynecology and a pioneer in the field of laparoscopy. On June ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... , Oct. 13, 2015 Health Gorilla ( ... Clinical Network – a secure platform for clinical data ... patients interact about and manage healthcare in the US. The ... round, for a combined total of $4.4M raised to date, ... from True Ventures , Harris Barton , ...
(Date:10/13/2015)... CARLOS, Calif. , Oct. 13, 2015   ... development advisory firm in Quantitative Systems Pharmacology (QSP)/ PhysioPD™ ... Chief Engineer, will lead a workshop at the ... 2015 in Boston, MA.  The ... in pharmaceutical drug development.  Dr. Friedrich,s workshop is entitled ...
(Date:10/13/2015)... , Oct. 13, 2015 China Jo-Jo ... " China Jo-Jo "), a leading China-based retail, wholesale ... through its own online and retail pharmacies, announced preliminary ... official branded online pharmacy through , growing ... a record 25%. China Jo-Jo,s ...
Breaking Medicine Technology: