Navigation Links
Brain scans show effects of Parkinson's drug
Date:11/30/2010

eeded to affect particular regions of the brain. They were able to demonstrate that the drug may be a viable therapy when combined with levodopa (L-Dopa), currently the most effective treatment for patients with Parkinson's disease.

The study, a Phase 2 clinical trial, used two doses of the investigational drug. Its safety already had been tested in healthy volunteers. The goal was to determine what might be a reasonable dose for a larger clinical trial in Parkinson's disease.

Unlike L-Dopa, which works through the brain's dopamine system, SYN115 interacts with the brain's adenosine A2a receptor. That receptor can modify the effects of the neurotransmitters glutamate and dopamine and is thought to be a potential therapeutic target not only for Parkinson's disease but also for insomnia, pain, drug addiction and depression.

"This study is important because it demonstrates this may be a useful approach for studying investigational drugs," says lead investigator Kevin J. Black, MD. "We were able to determine both that the drug gets into the brain to exert its effects and that it has a larger effect at a higher dose."

Black, a professor of psychiatry, of neurology, of neurobiology and of radiology, and his team used a new, FDA-approved type of perfusion MRI called arterial spin labeling (ASL), which uses MRI scans to measure blood flow in the brain. A similar technique uses positron emission tomography (PET) scans. Older forms of MRI scanning could not provide scientists with similar functional measurements.

Although PET scans can measure many of the same things, a large number of medical centers don't have PET scanners, and depending how it's done, PET may cost more, Black explains. The previous method of measuring blood flow with functional MRI is called BOLD scanning (Blood Oxygen Level Dependent).

"That's a wonderful technique for watching someone's brain respond to a question or a task or to compare blood
'/>"/>

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3 4 5

Related medicine news :

1. Acupuncture changes brains perception and processing of pain
2. Researchers identify a molecular switch that controls neuronal migration in the developing brain
3. Chronic high cholesterol diet produces brain damage
4. Better Helmet Design Might Lower Soldiers Risk for Brain Injury
5. Mayo Clinic study finds aggressive surgery is best for children with brain tumors
6. Protein found to predict brain injury in children on ECMO life support
7. Young Motorcycle Riders Suffering More Brain Injuries
8. Researchers identify PTSD measures for use in traumatic brain injury research
9. Key Brain Area for Vision May Be Organized by Color
10. Tiny Trojan horses attack brain cancer cells
11. Early Pot Use May Harm Brain More: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Brain scans show effects of Parkinson's drug
(Date:12/20/2014)... BambooIndustry.com is a professional company ... business has recently shown its new engineered bamboo flooring ... bamboo flooring models. , BambooIndustry.com’s customers come from many ... more. According to the CEO of the company, the ... in the past few years, and the demand for ...
(Date:12/20/2014)... Weddingshe.com has recently announced its new ... promotion of special occasion dresses for the coming new ... special occasion dresses for global women. Now, all the ... up to 80% off. Among the new items, the ... 16 Dress) is very popular. What’s more, Weddingshe.com also ...
(Date:12/20/2014)... York, NY (PRWEB) December 20, 2014 ... that allege a metal-on-metal version of the artificial ... forward in state and federal courts, Bernstein Liebhard ... New Jersey’ Bergen County Superior Court on December ... permitted to begin deposition of plaintiffs on November ...
(Date:12/20/2014)... Recently, VogueQueen.com, a leading wedding dress wholesaler and retailer, ... for 2015. Great discounts are now offered on all ... get a discount, up to 80% off, when they ... 30, 2015. , VogueQueen.com has recently released its new ... promotion. Many customers worldwide like VogueQueen’s special designs which ...
(Date:12/20/2014)... 2014 As Risperdal lawsuits ( ... U.S. courts, Bernstein Liebhard LLP notes the publication ... treated with the medication may experience elevated levels ... and lactation. The study, which appears in International ... who began treatment with risperidone, an antipsychotic medication ...
Breaking Medicine News(10 mins):Health News:BammbooIndustry.com: Big Discounts On All Kinds Of Bamboo Flooring Collections 2Health News:Tons of New-in Winter Sweet 16 Dresses from Weddingshe Online Now 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 3Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 4Health News:VogueQueen Big Sale Online For The Coming 2015 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 3Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 4
... prescription drug cards now available to older Americans offer ... which are marketed by private companies, charge seniors a ... exchange for discounts. But savings are minimal for many ... average, seniors in three large cities -- Washington, Chicago ...
... model that mimics two human hereditary dental defects-dentinogenesis ... Kulkarni and his colleagues genetically// engineered mice that ... beta-1) in their teeth. The animals were born ... their teeth became discolored and eventually fractured, leaving ...
... more or less than seven hours a night have increased ... over a six year time period// shows that the old ... need modifying. Looking at the length of time people sleep ... of Texas, and colleagues, find that seven hours is the ...
... no longer an exclusively Western problem. Researchers say ... to people in developing nations, particularly children. Until ... biggest threats to the health of poor people ... technology, food processing and even leisure time in ...
... The incidence of kidney cancer in the UK has risen by ... almost 6,000 people a year. Research in UK says that 5,700 ... are among the lowest in Europe.// The disease accounts for an ... the UK. ,According to Dr Nick James, a consultant at ...
... to conduct tests for any Indian doctor having graduated abroad ... a higher standards amongst doctors, the government has made it ... said today. , The new ... that students who want to enrol in MBBS course abroad ...
Cached Medicine News:Health News:Heriditary dental disorders 2
(Date:12/19/2014)... DIEGO and CARDIFF-BY-THE-SEA, Calif. ... Inc. (NASDAQ: SRNE ;  Sorrento), an ... associated pain, and Conkwest, Inc., a privately-held immuno-oncology ... Natural Killer (NK) cell-line based therapy, announced today ... agreement to jointly develop next generation CAR-TNK™ (pronounced ...
(Date:12/19/2014)... -- Decision Resources Group finds that the laparoscopic device market ... increase to a value of over $4.3 billion by ... the large direct energy device market. In particular, premium-priced ... to the advantages they offer and as new products ... Resources Group,s coverage of the U.S. laparoscopic device market: ...
(Date:12/19/2014)... 18, 2014   Aratana Therapeutics, Inc . ... focused on the licensing, development and commercialization of ... results from its pivotal field study of AT-001 ... in dogs with osteoarthritis.  In the study, dogs ... that were statistically significant compared to placebo (p<0.05) ...
Breaking Medicine Technology:Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5
... 3, 2011 Zimmer Holdings, Inc. (NYSE: ZMH ... and earnings conference call will be broadcast live over the ... Time.  A news release detailing the quarterly results will be ... the conference call. The live audio webcast ...
... NEW YORK, Oct. 3, 2011 BioElectronics Corporation (OTC: BIEL), ... today announced that Andrew J. Whelan, President, will present ... 5:00 PM EDTLINK: www.retailinvestorconferences.com > Click ... a live, interactive online event where investors are invited ...
Cached Medicine Technology:Zimmer Holdings Announces Live Audio Webcast and Conference Call of Third Quarter 2011 Results 2BioElectronics Corporation to Webcast, Live, at RetailInvestorConferences.com on October 6th 2
... The 1081 is an all-in-one drape ... The drape includes a pouch with filter ... finger cot. 64 inches (164cm) TUR ... Elastic aperture, Neoprene finger cot, Fluid collection ...
... Both the Penilab IV and the Penilab V ... studies. Model 1060 is similar to the Model ... nor can one be added later. The Penilab ... including all of the accessories you'll need to get ...
The Model 240 is a single-channel instrument designed for penile tumescence monitoring. It features exceptional stability. It's ready for use with most multi-channel recorders having a DC input....
... II SP MRI-Compatible Anesthesia System is perfect for ... than one type of anesthetic agent. , ... due to its wider stance, has a larger ... bellows assembly is utilized in both the Integra ...
Medicine Products: