Navigation Links
Brain responds same to acute and chronic sleep loss
Date:8/9/2010

MADISON, Wis. Burning the candle at both ends for a week may take an even bigger toll than you thought.

Researchers at the University of Wisconsin-Madison have found that five nights of restricted sleep--four hours a night--affect the brain in a way similar to that seen after acute total sleep deprivation.

The new study in rats, appearing in the current online edition of the Proceedings of the National Academy of Sciences, adds to the growing evidence scientists are accumulating about the negative effects of restricted sleep for both the brain and the body.

"There's a huge amount of interest in sleep restriction in the field today," says Dr. Chiara Cirelli, associate professor of psychiatry at the School of Medicine and Public Health, who led the research.

Many people are sleep restricted, either because they have to or because they choose to be, she says.

"Instead of going to bed when they are tired, like they should, people watch TV and want to have an active social life," she says. "People count on catching up on their sleep on the weekends, but it may not be enough."

This "casual" lack of sleep can be harmful.

"Even relatively mild sleep restriction for several nights can affect an individual's ability to perform cognitive tasks," Cirelli says. "For instance, recent studies in humans have shown that 5 days with only 4 h of sleep/night result in cumulative deficits in vigilance and cognition, and these deficits do not fully recover after one night of sleep, even if 10 hours in bed are allowed. Sleep restriction can also increase resistance to insulin, leading to a risk of diabetes."

Cirelli and her team kept rats awake 20 hours a day over five days while continuously recording the animals' brain waves with a sophisticated EEG as they were asleep and awake. The EEGs measured slow wave activity (SWA), the best marker of an individual's need to sleep as well as the intensity of sleep that follows a period of wakefulness.

"Slow-wave activity reflects the fact that sleep is regulated by homeostasis: in general, the longer we stay awake, the higher is SWA in the subsequent sleep. We knew that this was true after acute total sleep deprivation (for instance when we stay up all night); now we found that this is also true after chronic sleep restriction. " Cirelli notes..

According to the rat cumulative SWA measures, the sleep restriction produced intense recovery sleep following each wake cycle, with both longer and deeper sleep. The more effective the researchers were in keeping the animals awake during those 20 hours, the larger the sleep rebound they saw during the following four hours.

"It was an indirect but powerful indication of how sleepy the animals actually were," Cirelli says.

Even when the animals seemed awake and were moving around, heightened SWA was evident in their "wake" EEG.

"Monitoring SWA levels during waking time is very important in understanding the whole picture," she says. "High SWA levels during periods of both sleeping and waking signal that you need to go to sleep."

The researchers also found that SWA levels were different in different areas of the brain, and they speculate that this may depend on what parts of the brain had been used during the waking period.

Knowing that sleep restriction evokes the same brain response as sleep deprivation will help scientists better understand the harmful effects of sleep disturbances, says Cirelli.

"Scientists have learned much from 40 years of studies on total sleep deprivation, she says. "Now we know we can apply the lessons we learned from acute sleep deprivation to chronic sleep restriction, which is very relevant to people's lives today."


'/>"/>

Contact: Susan Lampert Smith
ssmith5@uwhealth.org
608-262-7335
University of Wisconsin-Madison
Source:Eurekalert

Related medicine news :

1. Gadgets not related to teenagers brain pain
2. Dementia Rates Escalate as Brain Capacity Diminishes with Age
3. Researchers discover new way to kill pediatric brain tumors
4. Scientists Pinpoint Area of Brain That Fears Losing Money
5. Physical Changes in Brain Linked to Altered Spirituality
6. Pro Athletes Brains React at Olympic Speed
7. Neuroscientists reveal new links that regulate brain electrical activity
8. Brain Scan Shows What Beauty is Worth
9. Study supports alternative anti-seizure medication following acute brain injury
10. Exercise helps protect brain of multiple sclerosis patients
11. Pittsburgh Neurosurgeons Explore Use of Drug that Illuminates Brain Tumor Cells To Guide Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/27/2016)... ... 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best Buy ... in the United States and Canada wear eyeglasses. Once considered to be a purely ... make a fashion statement. Even celebrities use glasses as a way of creating an ...
(Date:6/26/2016)... Battle Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... abuse, joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table ... held in honor of the city’s history as home to some of the world’s ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... PawPaws ... a new product that was developed to enhance the health of felines. The formula ... , The two main herbs in the PawPaws Cat Kidney Support Supplement ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... Research and Markets has announced the ... Tests" report to their offering. ... The World Market for Companion Diagnostics covers the ... analysis in the report includes the following: ... Kits) by Region (N. America, EU, ROW), 2015-2020 , ...
Breaking Medicine Technology: