Navigation Links
Brain region implicated in emotional disturbance in dementia patients
Date:7/12/2013

A study by researchers at Neuroscience Research Australia (NeuRA) is the first to demonstrate that patients with frontotemporal dementia (FTD) lose the emotional content/colour of their memories. These findings explain why FTD patients may not vividly remember an emotionally charged event like a wedding or funeral.

The research team discovered that a region of the brain, called the orbitofrontal cortex, plays a key role in linking emotion and memories.

"This step forward in the mapping of the brain will improve how we diagnose different types of dementia," says the study's lead author, Associate Professor Olivier Piguet.

The fact that we vividly remember events infused with emotion - like birthday parties - is well established. Patients with frontotemporal dementia (FTD) - a degenerative condition that affects the frontal and temporal lobes of the brain - show profound difficulty understanding and expressing emotion. Yet the extent to which such deficits weaken emotional enhancement of memory remains unknown.

To find out, the NeuRA team showed patients images that prompt an emotional reaction in healthy people. Healthy control subjects and patients with Alzheimer's disease remembered more emotional than neutral images. The FTD patients, however, did not.

Professor Piguet says, "Up until now, we knew that emotional memories were supported by the amygdala, a brain region also involved with emotion regulation. This study is the first to demonstrate the involvement of the orbitofrontal cortex in this process. This is an important development in how we understand the relations between emotions and memory and the disturbance of the emotional system in this type of dementia."

NeuRA researcher, Fiona Kumfor, says the findings will help carers better understand why their loved ones may find personal interactions difficult. "Imagine if you attended the wedding of your daughter, or met your grandchild for the first time, but this event was as memorable as doing the groceries. We have discovered that this is what life is like for patients with FTD," says Fiona.

"This is the first study that has looked at memory and emotion together in FTD and that is exciting. We now have new insight into the disease and can demonstrate that emotional memories are affected differently, depending on the type of dementia.

This information could help us create diagnostic tools and change how we diagnose certain types of dementias and differentiate between them. We have basically found the source of the deficit driving these impairments in patients, which brings us a step closer to understanding what it means to have FTD," she concluded.


'/>"/>

Contact: Kirsty Doole
kirsty.doole@oup.com
0044-186-535-5439
Oxford University Press
Source:Eurekalert

Related medicine news :

1. Voices Against Brain Cancer Commends Neuropsychologist and Team for Research on Cognitive Brain-Training for Cancer Survivors
2. CogniFit Launches a Specific Brain Training for ADHD
3. A fundamental problem for brain mapping
4. Voices Against Brain Cancer Comments on Discovery of a Cause of Resistance to Therapy in Cases of Brain Cancer
5. Suspicions confirmed: Brain tumors in children have a common cause
6. American Brain Tumor Association Conference to Help Patients/Caregivers Map Road to Wellness
7. Brain structural deficits may contribute to increased functional connections
8. Teens self-consciousness linked with specific brain, physiological responses
9. Long-term cannabis use may blunt the brains motivation system
10. 1 in 5 grade 7-12 students report having a traumatic brain injury in their lifetime
11. Memory improves for older adults using computerized brain-fitness program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... 2016 , ... An April Gallup survey found rising health care costs to ... Sun Health Senior Living (SHSL) may not share those same worries thanks to ... for the year, while holding the line on increasing their contributions, including premiums, deductibles ...
(Date:5/26/2016)... ... May 26, 2016 , ... Leadership of Life Science ... the organization has earned its ISO 13485 certification, indicating the company’s quality control ... rules and policies associated with ISO quality standard 13485. , BSI Group ...
(Date:5/26/2016)... Texas (PRWEB) , ... May 26, 2016 , ... ... Friday, May 13 at Blackhorse Golf Club in Cypress. With the help of community ... non-profit that restores, empowers, and renews hope for wounded service members and their families ...
(Date:5/26/2016)... ... May 26, 2016 , ... The MIAMI Institute for Age Management and ... Adonis Maiquez MD, ABAARM. Dr. Adonis , Wellness Physician of the MIAMI Institute ... of the Institute for Functional Medicine. , He also heads up FITTLab, the comprehensive ...
(Date:5/26/2016)... ... ... Bunion Bootie , the manufacturer of the newest and best in ... customer demand over the Mother’s Day Weekend promotion. So much so, that they completely ... completely replenished its inventory levels, it hopes to continue its current sales pace, and ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... ReportsnReports.com adds "Chronic Cough ... provides an overview on therapeutic pipeline of Chronic ... therapeutics assessment by drug target, mechanism of action ... along with latest updates, and featured news and ... in the therapeutic development for Chronic Cough and ...
(Date:5/24/2016)... 2016  Diana Russell suffers from a form of ... inside out.  This disease has put her in a ... and grandchildren to leave her home.  Because of the ... haul the wheelchair.  So if there is a family ... is left to wait for the bus. ...
(Date:5/24/2016)... May 24, 2016 The ... world , s first dual therapy stent, ...   OrbusNeich, a global company specializing in ... portfolio to include products to treat peripheral artery disease. ... first entry devices for lower limb and arteriovenous (AV) ...
Breaking Medicine Technology: