Navigation Links
Brain network linked to contemplation in adults is less complex in children
Date:3/7/2008

St. Louis, March 6, 2008 -- A brain network linked to introspective tasks -- such as forming the self-image or understanding the motivations of others -- is less intricate and well-connected in children, scientists at Washington University School of Medicine in St. Louis have learned. They also showed that the network establishes firmer connections between various brain regions as an individual matures.

The scientists are working to establish a picture of how these connections and other brain networks normally develop and interact. They want to use that picture to conduct more detailed assessments of the effects of aging, brain injuries and conditions such as autism on brain function.

"Having this information will not only help us understand what's going wrong in these patients, it will also allow us to better assess whether and how future interventions are providing those patients with effective treatment," says senior author Bradley L. Schlaggar, M.D., Ph.D., associate professor of pediatrics, radiology, neurology and anatomy and neurobiology.

The results appear online this week in The Proceedings of the National Academy of Sciences.

Neuroscientists including co-author Marcus E. Raichle, M.D., professor of radiology, of anatomy and neurobiology and of neurology first identified the network, which is called the default network, in 1996. Since then, scientists have linked it to a number of inward-looking activities, including the creation of the "autobiographical self," a person's internal narrative of their life story; and "mentalizing," the ability to analyze the mental states of others and use those insights to adjust the self's behavior appropriately.

Schlaggar, Raichle and colleagues including Steve Petersen, Ph.D., the James McDonnell Professor of Cognitive Neuroscience and professor of neurology and psychology, have been using a new technique called resting-state functional connectivity MRI to identify brain networks and analyze their functions and development. Instead of analyzing mental activity when a volunteer works on a cognitive task, resting-state connectivity scans their brains after they have been asked to rest and not engage in any specific tasks. The scans reveal changes in the oxygen levels in blood flowing to different areas of the brain. Researchers interpret correlations in the rise and fall of blood oxygen to different brain areas as a sign that those areas likely work together. In neuroscientist's terms, this means the regions have functional connectivity.

Damien A. Fair, a graduate student in Schlaggar's lab, led the new study, which compared functional connectivity in 13 brain regions linked to the default network in children ages seven to nine and adults ages 21 to 31.

"The difference between children and adults is profound," Fair says. "In a graph depicting the strength of connections between the brain regions we studied, children's minds have just a few connections between some regions, while the adult brains have a web-like mesh of many different interconnecting links involving all the regions."

In papers published in recent years, the researchers have used the same techniques to identify two networks that they think control much of the brain activity behind behaviors directed toward "external" goals (see http://mednews.wustl.edu/news/page/normal/9639.html and http://mednews.wustl.edu/news/page/normal/9778.html), including observing and interacting with the environment.

Schlaggar and colleagues plan further study of how the brain networks interact during development and in the mature brain. They also are looking at how network functions differ in patients with brain injuries and conditions such as autism.

"Autism spectrum disorder first manifests earlier than the time period we were studying," Schlaggar notes. "But many of the functions it affects have been associated with the default network, so we're eager to see if analysis of this network and its development can give us new insights into autism."


'/>"/>

Contact: Michael Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Vision restoration therapy shown to improve brain activity in brain injured patients
3. Clinical depression linked to abnormal emotional brain circuits
4. Brain imaging reveals breakdown of normal emotional processing
5. Brain cells work differently than previously thought
6. Vaccine Stops Alzheimers Brain Tangles
7. Research may unlock mystery of autisms origin in the brain
8. Scientists Spot Brains Free Will Center
9. Free will takes flight: how our brains respond to an approaching menace
10. Alcoholics With Cirrhosis Have More Brain Damage
11. Brain Lesions Predict MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... Despite last week’s media reports hinting ... and company to wait until March 2017 for an interest rate increase, according to ... College of Business. , “The Federal Open Market Committee (FOMC) dot charts are of ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... in intellectual property (IP) to its specialty academic programs. , Answering to the ... college’s existing certificate programs in health law, and environmental and land use law. ...
(Date:5/26/2016)... ... May 26, 2016 , ... There are nearly 14.5 ... 32 million cancer survivors worldwide. On Sunday, June 5, 2016, communities around the world ... Cancer Survivors Day®. , National Cancer Survivors Day® is an annual worldwide Celebration ...
(Date:5/26/2016)... ... 2016 , ... In an effort to provide hair restoration information to the widest possible audience, ... who do not use the app. Dr. Mohebi, the founder of Parsa Mohebi Hair Restoration, ... . , Dr. Mohebi says, “The positive response to the Snapchat videos we started ...
(Date:5/26/2016)... ... , ... North Cypress Medical Center hosted its 9th Annual Spring ... the help of community partners, the event organizers raised $45,000 for the Lone ... members and their families through health, wellness, and therapeutic support. , A special ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... YORK , May 25, 2016  According to ... reached $381 billion in 2015.  Though these are ... plenty of opportunity for success for companies that ... in search of new growth prospects medical device ... on research and development (R&D) than do companies ...
(Date:5/25/2016)... MedDay, a biotechnology company focused on the treatment ... "High doses of biotin in progressive multiple sclerosis: extension phase ... Ayman Tourbah , Principal Investigator of the Phase 3 ... Neurology (EAN) in Copenhagen, Denmark . The ... on Sunday, 29 May 2016 from 14:45 to 16:15 CEST ...
(Date:5/24/2016)... May 24, 2016   ... beide primären Endpunkte und demonstriert Ebenbürtigkeit ... ‚ausgezeichneter plus guter , ... ,      (Logo: http://photos.prnewswire.com/prnh/20130829/633895-a ... neue positive Daten von der MORA-Studie der Phase ...
Breaking Medicine Technology: