Navigation Links
Brain network decay detected in early Alzheimer's
Date:8/19/2013

In patients with early Alzheimer's disease, disruptions in brain networks emerge about the same time as chemical markers of the disease appear in the spinal fluid, researchers at Washington University School of Medicine in St. Louis have shown.

While two chemical markers in the spinal fluid are regarded as reliable indicators of early disease, the new study, published in JAMA Neurology, is among the first to show that scans of brain networks may be an equally effective and less invasive way to detect early disease.

"Tracking damage to these brain networks may also help us formulate a more detailed understanding of what happens to the brain before the onset of dementia," said senior author Beau Ances, MD, PhD, associate professor of neurology and of biomedical engineering.

Diagnosing Alzheimer's early is a top priority for physicians, many of whom believe that treating patients long before dementia starts greatly improves the chances of success.

Ances and his colleagues studied 207 older but cognitively normal research volunteers at the Charles F. and Joanne Knight Alzheimer's Disease Research Center at Washington University. Over several years, spinal fluids from the volunteers were sampled multiple times and analyzed for two markers of early Alzheimer's: changes in amyloid beta, the principal ingredient of Alzheimer's brain plaques, and in tau protein, a structural component of nerve cells.

The volunteers were also scanned repeatedly using a technique called resting state functional magnetic resonance imaging (fMRI). This scan tracks the rise and fall of blood flow in different brain regions as patients rest in the scanner. Scientists use the resulting data to assess the integrity of the default mode network, a set of connections between different brain regions that becomes active when the mind is at rest.

Earlier studies by Ances and other researchers have shown that Alzheimer's damages connections in the default mode network and other brain networks.

The new study revealed that this damage became detectable at about the same time that amyloid beta levels began to rise and tau levels started to drop in spinal fluid. The part of the default mode network most harmed by the onset of Alzheimer's disease was the connection between two brain areas associated with memory, the posterior cingulate and medial temporal regions.

The researchers are continuing to study the connections between brain network damage and the progress of early Alzheimer's disease in normal volunteers and in patients in the early stages of Alzheimer's-associated dementia.


'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Epilepsy Leads to More Brain Abnormalities Over Time
3. UCLA Brain Injury Research Center gets NCAA funding for research on sports concussions
4. Why is traumatic brain injury increasing among the elderly?
5. Brain Falters Near End of Life, but Games, Puzzles Might Slow Decline
6. Dental X-Rays May Be Linked to Benign Brain Tumors
7. Nonsurgical Method to Measure Brain Pressure Shows Promise
8. Researchers Map Brain Regions Linked to Intelligence
9. Football-related catastrophic brain injuries on the rise
10. Brain Tumor Vaccine Shows Promise in Early Trial
11. Brain Surgery Might Ease Tough-to-Treat OCD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... , ... June 23, 2017 , ... ... surgeon practicing in Newburgh, New York, has recently begun offering three new minimally ... offering the best cutting-edge procedures and reducing downtime, Dr. Rubinstein is excited to ...
(Date:6/23/2017)... ... June 23, 2017 , ... Goodcents Deli Fresh Subs today ... is located at 4210 SW 21st St. Topeka, Kan. 66604 (near 21st and Gage). ... Restaurant Group who owns three other locations in the Topeka and Bonner Springs, Kan. ...
(Date:6/23/2017)... ... June 23, 2017 , ... Georgia State University will ... 20. , The two-day conference is focused on advancing scientific knowledge about the ... lives and eliminating racial breast cancer-related disparities. The conference theme is “Illuminating Actionable ...
(Date:6/23/2017)... ... 23, 2017 , ... PureLife Dental is pleased to announce that California Dental ... As part of the amalgam separator endorsement, all CDA members may purchase an ECO ... the retail value. This partnership between PureLife and CDA is especially timely as it ...
(Date:6/23/2017)... San Francisco, CA (PRWEB) , ... June 23, 2017 , ... ... Conference on 26th June, 2017 from 9 am to 3 pm to present to ... curriculum. The program is an original curriculum project led by The Health Improvement ...
Breaking Medicine News(10 mins):
(Date:6/12/2017)... Kineta, Inc., a biotechnology company focused on the ... President of R&D and Head of Virology Kristin Bedard has ... the Northwest and Beyond meeting sponsored by Life Science ... from 8:30-10:30 AM PDT at the Agora Conference Center in ... Bedard will be joined by other leaders in infectious disease ...
(Date:6/8/2017)... 8, 2017  Less than a month ago, amateur ... 200,000 companies, including hospital networks, in over 150 countries. ... of the largest online extortion attempts ever recorded. With ... it is imperative that providers understand where the risks ... this — and many other very real cyber threats.  ...
(Date:6/7/2017)... June 6, 2017  Diplomat Specialty Infusion Group, a brand of ... to its Iowa location. The ... now features an ISO 7 cleanroom—the standard needed to compound ... a low level of pollutants. ... consumers and better serve our Iowa patients," ...
Breaking Medicine Technology: