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Brain implant surgeries at UCSF dramatically improve symptoms of debilitating condition
Date:3/8/2011

Implanting electrodes into a pea-sized part of the brain can dramatically improve life for people with severe cervical dystonia a rare but extremely debilitating condition that causes painful, twisting neck muscle spasms according to the results of a pilot study led by Jill Ostrem, MD and Philip Starr, MD PhD at the University of California, San Francisco.

Today, people with cervical dystonia can be treated with medications or injections of botulinum toxin (e.g., Botox), which interrupt signals from the brain that cause these spasms. However, those treatments do not provide adequate relief for all patients.

Over the last decade, doctors at UCSF and elsewhere have turned to a technique called deep brain stimulation to help people with debilitating dystonia. Also used to treat Parkinson's disease and the neurological disorder essential tremor, the technique is like putting a pacemaker inside a heart patient's chest except that deep brain stimulation requires a neurosurgeon to implant electrodes inside the brain.

Scientists are not sure exactly why deep brain stimulation works. The electrodes deliver electric current to tiny parts of the brain, likely altering abnormal brain circuitry and alleviating symptoms by overriding the signals coming from those parts of the brain.

Traditionally doctors have treated cervical dystonia with deep brain stimulation by targeting a brain nucleus known as the "globus pallidus internus." Reporting this week in the journal Neurology, the UCSF team described the results of the first detailed clinical study looking at deep brain stimulation targeting a completely different part of the brain: the "subthalamic nucleus."

"This target is very widely used for Parkinson's disease but not widely used for dystonia," said Starr, a professor of neurological surgery at UCSF and senior author of the paper.

The study, led by Ostrem, an associate professor of neurology at UCSF, involved nine
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Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

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