Navigation Links
Brain implant aims to stifle drug highs

What happens if addicts get no high from the drugs they take?

Researchers at Case Western Reserve and Illinois State universities have received a $390,000 National Institute on Drug Abuse grant to help answer the question.

Addiction experts believe a mechanism that robs drugs of their ability to hook users could treat and possibly cure drug abuse and even dependence.

Pedram Mohseni, an associate professor of electrical engineering and computer science at Case Western Reserve, is buildingand will soon start testinga brain implant aimed at sensing changes in the dopamine levels when a rat is given addictive substances and suppressing the reward-related signals associated with a pleasurable high.

"The idea is to build a closed-loop microsystem that senses and identifies changes in the dopamine levels induced by drugs of abuse, then activates a stimulator in real time to suppress the reward-related signals that promote drug-seeking behavior," said Mohseni, the leader of device development for the research project.

Mohseni has a first-generation prototype implant nearly ready and will take the device to Paul A. Garris, a professor of biological sciences at Illinois State, who will lead device testing in anesthetized laboratory rats as early as next month.

Mohseni's system is connected to a chemical microsensor that senses changes in the brain dopamine levels when a highly addictive amphetamine is administered.

The drug hyperactivates phasic dopamine signaling, or transient dopamine concentration spikes, which control brain reward pathways. This can lead to altered synaptic signaling and in turn overvaluation of cues predicting drug availability, leading to drug reinforcement, Mohseni said.

A computer circuit in the microsystem will use algorithms to determine if the drug-induced phasic dopamine signaling exceeds a threshold level set in the absence of drugs. When the threshold is exceeded, the system will then send electrical impulses to a stimulating electrode in the brain. The impulses are designed to inhibit dopamine neurons, silencing the phasic dopamine signaling.

Mohseni and Garris will spend the next two years evaluating and improving the microsystem. They plan to then seek another grant to test the device on rats that are awake and monitor changes in behavior.


Contact: Kevin Mayhood
Case Western Reserve University

Related medicine news :

1. Voices Against Brain Cancer Commends Brain Cancer Patient for Competing in Ironman Competitions
2. Digital PCR technology detects brain-tumor-associated mutation in cerebrospinal fluid
3. Tallahassee Girl Suffering from Chronic Headaches Diagnose with Lemon-sized Congenital Brain Cyst and Has Brain Surgery at Wolfson Children's Hospital in Jacksonville
4. Voices Against Brain Cancer Comments on Discovery of Nano Drug That May Aid in Treatment of Brain Tumors
5. Local Teen Organizes Charity WALK to Raise Awareness for Incurable Brain Condition
6. Mapping the brain to understand cultural differences
7. Nano drug crosses blood-brain tumor barrier, targets brain-tumor cells and blood vessels
8. Inner speech speaks volumes about the brain
9. Brain region implicated in emotional disturbance in dementia patients
10. Voices Against Brain Cancer Commends Neuropsychologist and Team for Research on Cognitive Brain-Training for Cancer Survivors
11. CogniFit Launches a Specific Brain Training for ADHD
Post Your Comments:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/26/2016)... Birmingham, Lake Orion, Clarkston, Michigan (PRWEB) , ... ... ... their direction with respect to fertility once they have been diagnosed with endometriosis. ... for tolerable intercourse but they also require a comprehensive approach that can help ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from reveals that behind the tendency to ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Story Highlights: ... the health care industry is causing providers to review ... Deloitte offers a suite of solutions for health care ... cost optimization: labor resource analysis, revenue cycle optimization and ... outcomes and better economics ...
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
Breaking Medicine Technology: