Navigation Links
Brain imaging reveals breakdown of normal emotional processing
Date:8/16/2007

WASHINGTON, DC, August 15, 2007 Brain imaging has revealed a breakdown in normal patterns of emotional processing that impairs the ability of people with clinical depression to suppress negative emotional states. Efforts by depressed patients to suppress their feelings when viewing emotionally negative images enhanced activity in several brain areas, including the amygdala, known to play a role in generating emotion, according to a report in the August 15 issue of The Journal of Neuroscience.

Identifying areas in the nervous system that correlate to pathological mood states is one of the pressing questions in mental illness today, says Carol Tamminga, MD, of the University of Texas Southwest Medical Center. Tamminga was not involved in the study.

Tom Johnstone, PhD, of the University of Wisconsin, and colleagues there and at Tufts University studied 21 adults diagnosed with major depressive disorder and 18 healthy subjects of comparable ages. Participants were asked to view a series of emotionally positive and negative images and then indicate their reaction to each one. Four seconds after the presentation of each picture, participants were asked either to increase their emotional response (for example, imagining a loved one experiencing what was depicted in the image), to decrease it, or simply to continue watching the image.

During the test, a functional magnetic resonance imaging scanner detected changes in neural activity. Johnstone and his colleagues also recorded levels of emotional excitement by measuring pupil dilation.

The data showed distinctive patterns of activity in the ventromedial prefrontal cortex (VMPFC) and the right prefrontal cortex (PFC), areas that regulate the emotional output generated from the amygdala. The VMPFC is compromised in depression, likely because of the inappropriate engagement of right PFC circuitry in depressed individuals.

These findings underscore the importance of emotional regulation deficits in depression, says Johnstone. They also suggest targets for therapeutic intervention.

According to previous research, normal interaction between the amygdala and the VMPFC may underlie the proper adaptation of levels of the stress hormone cortisol on a daily basis. These levels do not vary as widely in people with major depressive disorder; future research may now be able to clarify the mechanism that underlies this aspect of depression. It could also examine the possibility of using measurements of activity in the amygdala to predict the effectiveness of treatments for depression such as cognitive behavioral therapy.


'/>"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
Source:Eurekalert

Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Brain death – How to cope with it
3. Multi billion-dollar suit filed against cell phone firm for causing brain tumours
4. “Brain fingerprinting”- The new lie detectr
5. Nasal Spray Could Take Drugs Direct to Brain.
6. Two doctors suspended for wrong brain surgery
7. The brain loves a surprise
8. Virus Combats Brain Tumour
9. Increase in sugar...decrease in brain function!!!
10. Alcohol shrinks brain
11. Roller coaster takes brain for a big ride!!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... , ... December 07, 2016 , ... A quote from ... outpouring of comments on social media that offer a rare glimpse into the mind ... ADHD authority and New York Times bestselling author, has described people with ADHD as ...
(Date:12/7/2016)... ... December 07, 2016 , ... The Cliff Hart ... in South Lyon, Dewitt, Williamston, East Lansing, Ann Arbor, and Farmington Hills, is ... for a brain tumor. , Jason Bauer and his family are longtime members ...
(Date:12/7/2016)... ... ... A. Kevin Spann Insurance, a New York-based firm offering insurance and financial consultation ... drive to raise funds that will benefit the Marine Corps League. , The Marine ... Corpsmen. Working closely with the MCL, the A. Kevin Spann team plans to generate ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... Delete® - ... in Time For The Holiday Party Season. Save Up To 33% Off Botox® and ... Salon is providing the Phoenix Valley with Delightful Deals on Botox® and ...
(Date:12/7/2016)... ... 2016 , ... Gensuite is honored to be selected as ... Product Launch category. Gensuite’s entry on their EZ Scan feature detailed the tool’s ... Training Group is a professional event and training provider based in the United ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... 7, 2016  Organovo Holdings, Inc. (NASDAQ: ... focused on delivering scientific and medical breakthroughs using ... and Chief Executive Officer Keith Murphy ... December 14, 2016 at 1:00 p.m. Eastern Time ... yet familiar with the Company, an informational video ...
(Date:12/7/2016)... Today, Stock-Callers.com presents four Biotech equities for review, ... Pharmaceuticals Inc. (NASDAQ: ANTH ), ProNAi Therapeutics Inc. ... AVXS ). From its peak in July 2015, the ... level equal to what it saw at the start of ... year, it has still out-performed other market sectors, beating the ...
(Date:12/7/2016)... 7, 2016  Lannett Company, Inc. (NYSE: LCI ) ... Markets 2016 Prescription for Success Healthcare Conference on December 14, 2016 ... New York City . In addition, the ... Guggenheim Securities 4 th Annual Boston Healthcare Conference taking place ... ...
Breaking Medicine Technology: