Navigation Links
Brain damage found in cognitively normal people with Alzheimer's marker
Date:3/10/2009

March 10, 2009 -- Researchers at Washington University School of Medicine in St. Louis have linked a potential indicator of Alzheimer's disease to brain damage in humans with no signs of mental impairment.

Although their cognitive and neurological assessments were normal, study participants with lower levels of a substance known as amyloid beta 42 (A-beta 42) in their cerebrospinal fluid (CSF) had reduced whole brain volumes, suggesting that Alzheimer's changes might already be damaging their brains. Scientists previously showed that low CSF levels of A-beta 42 mark the presence of amyloid deposition in the brain, a key diagnostic marker of the amyloid plaques that characterize Alzheimer's disease.

Evidence is mounting that Alzheimer's harms the brain for many years before physicians and family members can detect symptoms, and this has led many to conclude that successful Alzheimer's treatments may only be possible if scientists find ways to identify pre-symptomatic sufferers.

The results are an encouraging sign that this search for new indicators, known as antecedent biomarkers, may be succeeding, according to senior author David M. Holtzman, M.D., the Andrew and Gretchen Jones Professor and chair of the Department of Neurology at the School of Medicine and neurologist-in-chief at Barnes-Jewish Hospital.

"We still need to confirm with long-term follow-up studies that subjects with this biomarker and brain damage go on to develop the cognitive changes characteristic of Alzheimer's," says Holtzman. "For now, the evidence we've uncovered further proves that identification and treatment prior to the start of the symptoms of Alzheimer's disease are likely going to be essential to preventing irreversible brain injury."

The results were published in the February issue of Annals of Neurology.

A-beta 42 is a protein fragment that clumps together in the brain to form the plaques that have long been the diagnos
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UH research team developing new noninvasive brain-mapping technology
2. Combo Treatment for Aggressive Brain Tumor May Lengthen Life
3. Think About It. Barry Spiegelman Memorial Golf Classic Benefits Brain Cancer Research
4. Brain tumors: New therapy surprisingly successful
5. Brain Tumor Drug May Help Spur Cancers Return
6. Brain tumor treatment may increase number of cancer stem-like cells
7. European Commission and United States Food and Drug Administration (FDA) Both Approve New Options for Patients With Certain Primary Brain Tumors
8. Now Hear This: Brain Fitness Exercises Improve Listening
9. Nearly 1.4 Million Sustain Traumatic Brain Injuries Each Year
10. National Council on Disability Says More Needs to be Done for Service Members and Veterans With Post Traumatic Stress Disorder and Traumatic Brain Injury
11. Brain Adapts to Age-Related Eye Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... US medical facilities are expected to ... in 2014. Due to public safety concerns, such waste ... municipal solid waste. An increasing number of laws and ... This includes disposable items that may be contaminated by ... a result of increased regulation, most small quantity RMW-generating ...
(Date:9/17/2014)... York (PRWEB) September 18, 2014 Mercy College ... Dean of the School of Social and Behavioral Sciences. ... enhancing the quality of the academic mission of the dynamic ... Dean said: “I am honored to join Mercy College. ... staff members across the campuses dedicated to the educational mission ...
(Date:9/17/2014)... September 17, 2014 In its latest ... drug and alcohol treatment program that gets clients off ... foundation in recovery they can believe in, is exploring ... 20% of Americans who are afflicted with depression are ... Forever Recovery’s CEO Per Wickstrom . “Unfortunately, these ...
(Date:9/17/2014)... September 17, 2014 Fitness-conscious people are ... even when they're already practicing or participating in specific ... to design a special fitness system that employs resistance ... or football," said an inventor from Maynard, Mass. , ... SYSTEM, which maximizes a body workout while the user ...
(Date:9/17/2014)... Cut Pro X plugin developers have announced a new anamorphic ... “ProBlue 5k is a compilation of anamorphic flares that can ... Austin, CEO of Pixel Film Studios. “Blurring the line between ... , ProBlue 5k is the ultimate Ultra High Definition anamorphic ... compilation of over 100 anamorphic flares can be applied to ...
Breaking Medicine News(10 mins):Health News:Medical Waste Disposal Services in the US Industry Market Research Report Now Available from IBISWorld 2Health News:Medical Waste Disposal Services in the US Industry Market Research Report Now Available from IBISWorld 3Health News:Mercy College Welcomes New Dean of the School of Social and Behavioral Sciences 2Health News:Latest A Forever Recovery Blog Post Explores the Link Between Addiction and Depression 2Health News:Latest A Forever Recovery Blog Post Explores the Link Between Addiction and Depression 3Health News:A New Plugin Entitled ProBlue 5k Was Released Today from Pixel Film Studios Exclusively for Final Cut Pro X 2
... Research Inc. (TSX: NRI), a Canadian drug development company ... that are delivered to and through the skin using ... its financial and operational results for the year and ... Key Corporate Developments:, - ...
... radiologists and referring, ... physicians and specialists , ... GE Healthcare,announced today in Asia the release of Centricity PACS Web ... is tightly,integrated to Centricity RIS/ PACS, which bring comprehensive detailed patient,history ...
... Nursing Productivity in the Treatment of Renal Disease , ... ... 2009 -- iSirona®, an innovative provider of data automation solutions ... agreement with NxStage Medical, Inc. (Nasdaq: NXTM), a leading manufacturer ...
... announces the implementation of its rehabilitation software by HealthPoint ... Southeast Missouri Hospital, a 269-bed regional medical complex serving ... functionality for electronically managing therapy documentation, scheduling, referrals, insurance ... ...
... , New web-based research has quantified the attractiveness of ... the features of one woman into 243 variations with ... waist widths. Then more than 34,000 people judged the ... exactly the same in all of the photos, researchers ...
... Modernizes TechnologyWASHINGTON, Feb. 26 President Obama,s first ... (VA) expands eligibility for health care to an ... years, meets the need for continued growth in ... Afghanistan and provides the resources to deliver quality ...
Cached Medicine News:Health News:Nuvo announces 2008 fourth quarter and year-end financial results 2Health News:Nuvo announces 2008 fourth quarter and year-end financial results 3Health News:Nuvo announces 2008 fourth quarter and year-end financial results 4Health News:Nuvo announces 2008 fourth quarter and year-end financial results 5Health News:Nuvo announces 2008 fourth quarter and year-end financial results 6Health News:Nuvo announces 2008 fourth quarter and year-end financial results 7Health News:Nuvo announces 2008 fourth quarter and year-end financial results 8Health News:Nuvo announces 2008 fourth quarter and year-end financial results 9Health News:Nuvo announces 2008 fourth quarter and year-end financial results 10Health News:Nuvo announces 2008 fourth quarter and year-end financial results 11Health News:Nuvo announces 2008 fourth quarter and year-end financial results 12Health News:GE Healthcare Introduces New Web-Based Diagnostic Viewer with Workflow Integration and Streaming Technology for Hospitals in Asia 2Health News:GE Healthcare Introduces New Web-Based Diagnostic Viewer with Workflow Integration and Streaming Technology for Hospitals in Asia 3Health News:iSirona Signs Reference Selling Agreement with NxStage 2Health News:Southeast Missouri Hospital Implements Chart Links Rehabilitation Software for Therapists 2Health News:Southeast Missouri Hospital Implements Chart Links Rehabilitation Software for Therapists 3Health News:Plastic and reconstructive surgery ... in brief 2Health News:President's 2010 Budget Request Strongly Supports VA Programs 2
(Date:9/17/2014)... , Sept. 17, 2014 ... Summary GlobalData,s new ... provides key market data on the Brazil Gynecological ... of US dollars, volume (in units) and average ... Female Sterilization Devices (Transcervical Sterilization Devices (Micro-inserts) and ...
(Date:9/17/2014)... Sept. 17, 2014  Levi & Korsinsky, LLP is ... possible claims of breaches of fiduciary duty by the ... get more information, click here: http://zlk.9nl.com/alexza-pharmaceuticals-alxa . There ... If you own common stock in Alexza Pharmaceuticals Inc. ... Eduard Korsinsky, Esq. either via email at ...
(Date:9/17/2014)... PITTSBURGH , Sept. 17, 2014 /PRNewswire-iReach/ ... a white paper discussing improvements in the ... anatomic structures for both normal and diseased ... real-time information, simplifies surgical procedures, lowers surgical ... robot-assisted surgical procedures. The ...
Breaking Medicine Technology:Brazil Gynecological Devices Market Outlook to 2020 2Brazil Gynecological Devices Market Outlook to 2020 3Patient Outcomes Improve When Molecular Chemical Imaging Technology Is Used to Aid Robotic Surgical Procedures, According to New White Paper 2
... ... Schizophrenia, WASHINGTON, MAY 6 Data ... candidate,iloperidone, included its 4-week, short-term Phase III trial, as well as ... of iloperidone. Iloperidone is a 5HT2/D2 antagonist ("atypical"),antipsychotic currently under review ...
... - Data Presented in Poster Session at American College ... Gynecologists, 56th Annual ... PEAK Surgical, Inc., a medical,device company that is ... released results from a preclinical study,demonstrating that its PEAK ...
Cached Medicine Technology:Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidone's Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events 2Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidone's Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events 3Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidone's Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events 4Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidone's Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events 5Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidone's Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events 6Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidone's Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events 7PEAK Surgical Announces Positive Results From Preclinical Study of PEAK PlasmaBlade(TM) for Obstetric and Gynecologic Surgery 2PEAK Surgical Announces Positive Results From Preclinical Study of PEAK PlasmaBlade(TM) for Obstetric and Gynecologic Surgery 3PEAK Surgical Announces Positive Results From Preclinical Study of PEAK PlasmaBlade(TM) for Obstetric and Gynecologic Surgery 4
Heavy duty, all purpose illuminator available in black only. Unique Clip Switch automatically turns off when returned to pocket. Pre-focused lens tip Heine XHL Halogen bulb for bright, concentrated l...
Convenient clip-activated switch with removable cobalt blue filter attachment....
Convenient clip-activated switch with imprinted 2 mm - 9 mm pupil gauge and medical caduceus....
... most affordable, compact and lightweight video magnifier. ... 18 pounds, the Companion is the perfect ... Companions easy-to-use controls allow you to read ... magazines, newspapers and even curved surfaces on ...
Medicine Products: