Navigation Links
Brain damage found in cognitively normal people with Alzheimer's marker
Date:3/10/2009

March 10, 2009 -- Researchers at Washington University School of Medicine in St. Louis have linked a potential indicator of Alzheimer's disease to brain damage in humans with no signs of mental impairment.

Although their cognitive and neurological assessments were normal, study participants with lower levels of a substance known as amyloid beta 42 (A-beta 42) in their cerebrospinal fluid (CSF) had reduced whole brain volumes, suggesting that Alzheimer's changes might already be damaging their brains. Scientists previously showed that low CSF levels of A-beta 42 mark the presence of amyloid deposition in the brain, a key diagnostic marker of the amyloid plaques that characterize Alzheimer's disease.

Evidence is mounting that Alzheimer's harms the brain for many years before physicians and family members can detect symptoms, and this has led many to conclude that successful Alzheimer's treatments may only be possible if scientists find ways to identify pre-symptomatic sufferers.

The results are an encouraging sign that this search for new indicators, known as antecedent biomarkers, may be succeeding, according to senior author David M. Holtzman, M.D., the Andrew and Gretchen Jones Professor and chair of the Department of Neurology at the School of Medicine and neurologist-in-chief at Barnes-Jewish Hospital.

"We still need to confirm with long-term follow-up studies that subjects with this biomarker and brain damage go on to develop the cognitive changes characteristic of Alzheimer's," says Holtzman. "For now, the evidence we've uncovered further proves that identification and treatment prior to the start of the symptoms of Alzheimer's disease are likely going to be essential to preventing irreversible brain injury."

The results were published in the February issue of Annals of Neurology.

A-beta 42 is a protein fragment that clumps together in the brain to form the plaques that have long been the diagnos
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UH research team developing new noninvasive brain-mapping technology
2. Combo Treatment for Aggressive Brain Tumor May Lengthen Life
3. Think About It. Barry Spiegelman Memorial Golf Classic Benefits Brain Cancer Research
4. Brain tumors: New therapy surprisingly successful
5. Brain Tumor Drug May Help Spur Cancers Return
6. Brain tumor treatment may increase number of cancer stem-like cells
7. European Commission and United States Food and Drug Administration (FDA) Both Approve New Options for Patients With Certain Primary Brain Tumors
8. Now Hear This: Brain Fitness Exercises Improve Listening
9. Nearly 1.4 Million Sustain Traumatic Brain Injuries Each Year
10. National Council on Disability Says More Needs to be Done for Service Members and Veterans With Post Traumatic Stress Disorder and Traumatic Brain Injury
11. Brain Adapts to Age-Related Eye Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... (PRWEB) July 28, 2014 To commemorate ... Editorial Board of Living with a Disability magazine ... disabling digestive disorders that include hepatitis, gastrointestinal hemorrhage, inflammatory ... , The important new article highlights that, in the ... afflicted with hepatitis and other disabling conditions related to ...
(Date:7/28/2014)... July 28, 2014 According to the Heartburn ... a comprehensive guide that will help people get rid of ... all the necessary information about heartburn and acid reflux. In ... about heartburn , and risk factors for reflux disease. ... help people get rid of symptoms of reflux disease naturally ...
(Date:7/28/2014)... According to the Drama Method Pdf review ... that helps women easily get the attention of the men ... in its review that this book can teach ladies how ... The book also instructs them how to conquer a man, ... Drama Method review that this book is divided into 30 ...
(Date:7/28/2014)... 2014 Building a sense of neighborhood ... Where personal outdoor space is not possible, building ... fun and exercise outside is important. That’s why ... quality commercial playground equipment from APCPLAY. , Old Buckingham ... Virginia. It is an historic tourist location of one ...
(Date:7/28/2014)... Mitul R. Patel, DDS and concerned leading Dentists ... Experts Benefit Dinner May 30, in St. Petersburg, FL. ... raise funds for the Improving Youth Literacy Campaign in ... Programs across America. The funds raised are providing hundreds ... books to directly tackle illiteracy and help to break ...
Breaking Medicine News(10 mins):Health News:Living with a Disability Magazine Marks World Hepatitis Day on July 28 with New Article on Disabling Digestive Disorders 2Health News:Living with a Disability Magazine Marks World Hepatitis Day on July 28 with New Article on Disabling Digestive Disorders 3Health News:Heartburn No More Pdf Review Exposes Jeff Martin's Guide For Treating Heartburn – Vkool.com 2Health News:Heartburn No More Pdf Review Exposes Jeff Martin's Guide For Treating Heartburn – Vkool.com 3Health News:The Drama Method Pdf Review Exposes Aaron Fox's Relationship Guide – Vkool.com 2Health News:The Drama Method Pdf Review Exposes Aaron Fox's Relationship Guide – Vkool.com 3Health News:Playground Creates Outdoor Fun for Community at Old Buckingham Station at Midlothian Village (VA) with APCPLAY© 2Health News:Mitul R. Patel, DDS Successfully Attacks a Major Source of Economic Destruction in the Battle Against Illiteracy and Poverty 2Health News:Mitul R. Patel, DDS Successfully Attacks a Major Source of Economic Destruction in the Battle Against Illiteracy and Poverty 3
... depression, study suggests , , WEDNESDAY, Aug. 29 (HealthDay News) -- ... be as simple as seeing which arm she uses to ... mothers who cradle their baby on their right side may ... mothers feel some levels of stress during the first weeks ...
... a 58-year-old business owner from Waxahachie, Texas, was fortunate. ... but a side effect of his successful surgery was ... cancer, I started experiencing incontinence, said Mr. Yarborough, who ... better than most, the condition, simply put, drove me ...
... anesthesia, faster recovery, less cost, study finds , , TUESDAY, Aug. ... may ease the pain of surgery -- both during and ... who received hypnosis before breast cancer surgery needed less anesthesia ... in the operating room and had reduced costs. , ...
... and therapies, researchers say , , TUESDAY, Aug. 28 (HealthDay ... of multiple sclerosis patients may help predict the severity ... reporting. , "This is a new way to ... of the patient,s lesions," said lead researcher Dr. Rohit ...
... ear, nose and throat specialists at Thomas Jefferson University ... apnea syndrome. , In the procedure, known as Genial ... lower jaw which attaches to the tongue is moved ... of the airway, increasing the airway space. It is ...
... Genes connected with higher functions are changed by continued ... -- Alcoholics with cirrhosis (scarring and dysfunction) of the ... according to new research. , Researchers examined gene expression ... alcoholics with cirrhosis and 14 alcoholics without cirrhosis. , ...
Cached Medicine News:Health News:Stressed-Out Moms Carry Babies on the Right 2Health News:New male sling procedure helps prostate cancer survivors who suffer from urinary incontinence 2Health News:Hypnosis Eases Pain of Breast Cancer Surgery 2Health News:Hypnosis Eases Pain of Breast Cancer Surgery 3Health News:Brain Lesions Predict MS Progression 2Health News:Brain Lesions Predict MS Progression 3Health News:Jefferson specialists studying innovative surgery for effectively treating sleep apnea 2Health News:Alcoholics With Cirrhosis Have More Brain Damage 2
(Date:7/28/2014)... und LONDON , July ... , Ziel der Zusammenarbeit sind Entwicklung und Kommerzialisierung ... Plasmaproben zur Steuerung von Therapien mit IRESSA bei ... Neuer Bluttest basiert auf QIAGENs von der ... Rotor-Gene Q, einer Automationsplattform der QIAsymphony-Produktfamilie, laufen  ...
(Date:7/28/2014)... , Germany and ... , Collaboration aims to create and ... to guide the use of IRESSA  for non-small cell ... build on QIAGEN,s FDA-approved  therascreen   EGFR test and is ... of automated instruments  Project enabled by AstraZeneca ...
(Date:7/28/2014)... , July 28, 2014 CTI BioPharma ... it will report its second quarter 2014 financial results ... the U.S. financial markets. Following the announcement, members of ... to discuss the results and provide a general corporate ... to the event can be obtained as follows: ...
Breaking Medicine Technology:QIAGEN und AstraZeneca entwickeln Begleittest auf Basis von Flüssigbiopsien zur erweiterten Bestimmung von EGFR-Mutationen bei Lungenkrebspatienten 2QIAGEN und AstraZeneca entwickeln Begleittest auf Basis von Flüssigbiopsien zur erweiterten Bestimmung von EGFR-Mutationen bei Lungenkrebspatienten 3QIAGEN und AstraZeneca entwickeln Begleittest auf Basis von Flüssigbiopsien zur erweiterten Bestimmung von EGFR-Mutationen bei Lungenkrebspatienten 4QIAGEN und AstraZeneca entwickeln Begleittest auf Basis von Flüssigbiopsien zur erweiterten Bestimmung von EGFR-Mutationen bei Lungenkrebspatienten 5QIAGEN und AstraZeneca entwickeln Begleittest auf Basis von Flüssigbiopsien zur erweiterten Bestimmung von EGFR-Mutationen bei Lungenkrebspatienten 6QIAGEN und AstraZeneca entwickeln Begleittest auf Basis von Flüssigbiopsien zur erweiterten Bestimmung von EGFR-Mutationen bei Lungenkrebspatienten 7QIAGEN and AstraZeneca Collaborate to Develop Liquid Biopsy-Based Companion Diagnostic to Advance EGFR Mutation Profiling in Lung Cancer Patients 2QIAGEN and AstraZeneca Collaborate to Develop Liquid Biopsy-Based Companion Diagnostic to Advance EGFR Mutation Profiling in Lung Cancer Patients 3QIAGEN and AstraZeneca Collaborate to Develop Liquid Biopsy-Based Companion Diagnostic to Advance EGFR Mutation Profiling in Lung Cancer Patients 4QIAGEN and AstraZeneca Collaborate to Develop Liquid Biopsy-Based Companion Diagnostic to Advance EGFR Mutation Profiling in Lung Cancer Patients 5QIAGEN and AstraZeneca Collaborate to Develop Liquid Biopsy-Based Companion Diagnostic to Advance EGFR Mutation Profiling in Lung Cancer Patients 6CTI BioPharma to Report Second Quarter 2014 Financial Results on August 4, 2014 2
... Receiving the herpes zoster vaccine was associated with a ... Kaiser Permanente study of 300,000 people that appears in the ... Association . This retrospective study observed the outcomes ... large, diverse population of men and women ages 60 years ...
... 11, 2011 Celleration, Inc., a privately held medical ... products, today announced the closing of an $8 million ... Company,s existing institutional investors participated in this round in ... a new investor. "The addition of ...
Cached Medicine Technology:Shingles Vaccine Associated With 55 Percent Reduced Risk of Disease 2Shingles Vaccine Associated With 55 Percent Reduced Risk of Disease 3Shingles Vaccine Associated With 55 Percent Reduced Risk of Disease 4
Stryker Leibinger offers a variety of different Titanium Implant Systems and special instrument sets, which enable our customers to treat a wide range of indication...
Stryker Leibinger offers a variety of different Titanium Implant Systems and special instrument sets, which enable our customers to treat a wide range of indication...
Anatomical implants for the entire hand, in five sizes...
... a brief magnetic pulse to stimulate deep ... in Magnetic Nerve Stimulators. Based upon equipment ... in 1985. A powerful monophasic stimulator for ... best stimulator for Central Motor Conduction Studies, ...
Medicine Products: