Navigation Links
Brain chemical may explain why heavy smokers feel sad after quitting
Date:8/2/2011

August 2 (Toronto) Heavy smokers may experience sadness after quitting because early withdrawal leads to an increase in the mood-related brain protein monoamine oxidase A (MAO-A), a new study by the Centre for Addiction and Mental Health (CAMH) has shown. This finding, which was published in the Archives of General Psychiatry, may also explain why heavy smokers are at high risk for clinical depression.

Using an advanced brain imaging method, a team led by Senior Scientist Dr. Jeffrey Meyer discovered that MAO-A levels in the brain regions that control mood rose by 25 per cent eight hours after withdrawal from heavy cigarette smoking. These levels were much higher than in a comparison group of non-smoking study participants. All 48 participants filled out questionnaires, and smokers with high brain MAO-A levels during withdrawal also reported greater feelings of sadness.

"Understanding sadness during cigarette withdrawal is important because this sad mood makes it hard for people to quit, especially in the first few days. Also, heavy cigarette smoking is strongly associated with clinical depression," said Dr. Meyer, who holds a Canada Research Chair in the Neurochemistry of Major Depression. "This is the first time MAO-A, a brain protein known to be elevated in clinical depression has been studied during cigarette withdrawal."

MAO-A "eats up" chemicals in the brain, such as serotonin, that help maintain a normal mood. When MAO-A levels are higher as in early cigarette withdrawal, it means that this removal process is overly active, making people feel sad. For this study, MAO-A was detected using a brain imaging technique called positron emission tomography (PET). CAMH has the only PET scanner in the world dedicated solely to mental health and addiction research.

A specific substance in cigarette smoke, called harman, may be responsible for these changes, the researchers note. During active smoking, harman attac
'/>"/>

Contact: Michael Torres
media@camh.net
416-595-6015
Centre for Addiction and Mental Health
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Smoking, Diabetes, Obesity May Shrink Your Brain
2. New CMU brain imaging research reveals why autistic individuals confuse pronouns
3. Concussion Project Finds Disease in Two Autopsied Brains
4. Brain Injury Appears to Boost Stroke Risk
5. The brains connectome -- from branch to branch
6. Children and adolescent mobile phone users at no greater risk of brain cancer than non-users
7. New imaging technique captures brain activity in patients with chronic low back pain
8. Researchers aim for direct brain control of prosthetic arms
9. Eliminating protein in specific brain cells blocks nicotine reward
10. Fatty Comfort Foods May Alter Brains Response to Sadness
11. Brain autopsies of 4 former football players reveal not all get chronic traumatic encephalopathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... July 30, 2014 Ticket Down is ... Tickets in Ann Arbor, MI on Saturday, August 2nd. ... international football will be competing on American soil on Aug. 2 ... in Ann Arbor, Mich. The home of the University of Michigan ... the most prestigious in all of American sports and has also ...
(Date:7/30/2014)... HealthDay Reporter WEDNESDAY, July ... their preschooler shed excess pounds may want to team up ... joined them in a supervised behavioral modification program gained less ... child-only program (an average difference of about four pounds over ... pounds over two years, according to the study. "In ...
(Date:7/30/2014)... well as evolutionary changes in a living organismhad been ... the genome. , However, recent studies have shown that ... that arise simultaneously and in close proximity to each ... in regions where chromosomal rearrangements take place. , The ... may one day lead to new cancer therapies, according ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 Hamilton ... opening of its new Carmel office on July 30th. ... will finally be moving to the state-of-the-art suite, located ... and innovative space will allow for one-on-one patient comfort, ... surgery experience. , Dr. Hamilton’s new office-suite will ...
(Date:7/30/2014)... 2014. A new network of 25 regional stroke centers ... (NIH StrokeNet) is working to change the way ... advances of the last two decades, stroke remains a ... or disability for 795,000 Americans. The numbers are expected ... , To accelerate the pace of progress, NIH ...
Breaking Medicine News(10 mins):Health News:Manchester United vs. Real Madrid Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for Real Madrid vs. ManU Guinness International Champions Cup Match 2Health News:Manchester United vs. Real Madrid Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for Real Madrid vs. ManU Guinness International Champions Cup Match 3Health News:Manchester United vs. Real Madrid Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for Real Madrid vs. ManU Guinness International Champions Cup Match 4Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 2Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 3Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 4Health News:Biologists describe mechanism promoting multiple DNA mutations 2Health News:Hamilton Facial Plastic Surgery Opens New Carmel Office 2Health News:Kessler funded as satellite site for NIH Stroke Trials Network 2
... , ... recent report in the medical journal Osteoporosis International found that women taking AdvaCAL® calcium ... 1977 and 2008. The 32 studies involved 3,169 postmenopausal women, 79 skeletal measures and ... ...
... ... settled in Dubai, received the very prestigious ,HIND RATTAN AWARD, this week ... was presented at a ceremony in connection with the yearly International Congress ... Industries and Public Enterprises, Government of India. Dr. Mehta was awarded for ...
... ... Logan Consulting, a Chicago, IL based management consulting and technology firm, ... Chicago, IL based Microsoft Gold Certified Partner, effective January 1, 2010. ... services, serving clients across North America, Europe and Asia since 1992. ...
... ... connectors, is utilizing their nano-connector Bi-lobes® to help handle difficult signal routing and ... ... the leading manufacturer of miniature high-rel connectors, is utilizing their nano-connector Bi-lobes® to ...
... ... Vemma Nutrition Company launches Vemma THIRST, ... other sports drinks, Vemma THIRST goes beyond hydration by delivering ... while replenishing the body with necessary electrolytes, specialized carbohydrates and ...
... , Majority of Mississippi voters support e-tracking ... The following is a statement by Linda ... Association (CHPA): , "Today, the Mississippi House of Representatives ... becomes law, will greatly limit how cold and allergy sufferers access ...
Cached Medicine News:Health News:Report: AdvaCALCalcium Builds Bone Best 2Health News:Dr. Mahaveer Mehta, A Well Known Dermatologist from Dubai, Receives Prestigious 'Hind Rattan Award' 2Health News:Dr. Mahaveer Mehta, A Well Known Dermatologist from Dubai, Receives Prestigious 'Hind Rattan Award' 3Health News:Logan Consulting Merges with Cornerstone Solutions 2Health News:Logan Consulting Merges with Cornerstone Solutions 3Health News:Omnetics Nano-to-Flex Connectors Solve Big Problems in Small Spaces 2Health News:Vemma Revolutionizes the Sports Drink Market With Vemma THIRST™ 2Health News:Statement from the Consumer Healthcare Products Association on Mississippi Bill that Seeks to Make Cold, Allergy Medicines Containing Pseudoephedrine Prescription-Only 2Health News:Statement from the Consumer Healthcare Products Association on Mississippi Bill that Seeks to Make Cold, Allergy Medicines Containing Pseudoephedrine Prescription-Only 3
(Date:7/30/2014)... BEDFORD, Mass., July 30, 2014  Hologic, Inc. (NASDAQ: ... the third fiscal quarter ended June 28, 2014. ... , Revenues increased 1.0% to $632.6 million, reflecting operational ... 0.5%, compared to the same period in the prior ... four business segments. , Breast Health revenues grew 3.5%. ...
(Date:7/30/2014)... , July 30, 2014 The ... Care Pharmacy (AMCP) last evening expressed support for ... the Joint Commission of Pharmacy Practitioners (JCPP).  As ... organizations over a two-year period to develop a ... pharmacists.  "Pharmacists are fast becoming ...
(Date:7/30/2014)... , July 30, 2014  El Camino Hospital, a ... care, is utilizing the Leaf Patient Monitoring system to ... and movement of patients susceptible to bed sores. ... month-long, 138-patient study of the system, which showed dramatic ... Turning patients regularly is the one of the most ...
Breaking Medicine Technology:Hologic Announces Third Quarter Fiscal 2014 Operating Results 2Hologic Announces Third Quarter Fiscal 2014 Operating Results 3Hologic Announces Third Quarter Fiscal 2014 Operating Results 4Hologic Announces Third Quarter Fiscal 2014 Operating Results 5Hologic Announces Third Quarter Fiscal 2014 Operating Results 6Hologic Announces Third Quarter Fiscal 2014 Operating Results 7Hologic Announces Third Quarter Fiscal 2014 Operating Results 8Hologic Announces Third Quarter Fiscal 2014 Operating Results 9Hologic Announces Third Quarter Fiscal 2014 Operating Results 10Hologic Announces Third Quarter Fiscal 2014 Operating Results 11Hologic Announces Third Quarter Fiscal 2014 Operating Results 12Hologic Announces Third Quarter Fiscal 2014 Operating Results 13Hologic Announces Third Quarter Fiscal 2014 Operating Results 14Hologic Announces Third Quarter Fiscal 2014 Operating Results 15Hologic Announces Third Quarter Fiscal 2014 Operating Results 16Hologic Announces Third Quarter Fiscal 2014 Operating Results 17AMCP Endorses JCPP "Pharmacists' Patient Care Process" 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 3
... 09, 2007 /PRNewswire-FirstCall/ --,Catalyst Pharmaceutical Partners, Inc. ... bioequivalence study demonstrating,that CPP-109 (Catalyst's Vigabatrin Tablets) ... version of vigabatrin marketed,in Europe by Sanofi ... linking CPP-109 to the extensive body of ...
... N.J. and BRISTOL, Tenn., May 09, 2007,/PRNewswire-FirstCall/ ... today announced plans to present the results,from ... with erectile,dysfunction (ED). The presenters are Jed ... NYU School of Medicine;,Stanley E. Althof, PhD, ...
Cached Medicine Technology:Catalyst Pharmaceutical Partners, Inc. Announces Top-Line Results,of Its Bioequivalence Study of CPP-109 (Vigabatrin), the Company's,Investigational Drug to Treat Cocaine and Methamphetamine Addiction 2Catalyst Pharmaceutical Partners, Inc. Announces Top-Line Results,of Its Bioequivalence Study of CPP-109 (Vigabatrin), the Company's,Investigational Drug to Treat Cocaine and Methamphetamine Addiction 3Catalyst Pharmaceutical Partners, Inc. Announces Top-Line Results,of Its Bioequivalence Study of CPP-109 (Vigabatrin), the Company's,Investigational Drug to Treat Cocaine and Methamphetamine Addiction 4Palatin Technologies and King Pharmaceuticals Announce Plan To,Present Results of Bremelanotide Phase 2b Studies in Men With,Erectile Dysfunction 2Palatin Technologies and King Pharmaceuticals Announce Plan To,Present Results of Bremelanotide Phase 2b Studies in Men With,Erectile Dysfunction 3Palatin Technologies and King Pharmaceuticals Announce Plan To,Present Results of Bremelanotide Phase 2b Studies in Men With,Erectile Dysfunction 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: