Navigation Links
Brain cell discovery could open doors to targeted cancer therapies
Date:4/11/2014

Fresh insights into the processes that control brain cell production could pave the way for treatments for brain cancer and other brain-related disorders.

Scientists have gained new understanding of the role played by a key molecule that controls how and when nerve and brain cells are formed a process that allows the brain to develop and keeps it healthy. Their findings could help explain what happens when cell production goes out of control, which is a fundamental characteristic of many diseases including cancer.

Researchers have focused on a RNA molecule, known as miR-9, which is linked to the development of brain cells, known as neurons and glial cells. They have shown that a protein called Lin28a regulates the production of miR-9, which in turn controls the genes involved in brain cell development and function.

Scientists carried out lab studies of embryonic cells, which can develop into neurons, to determine how Lin28a controls the amount of miR-9 that is produced.

They found that in embryonic cells, Lin28a prevents production of miR-9 by triggering the degradation of its precursor molecule. In developed brain cells, Lin28a is no longer produced, which enables miR-9 to accumulate and function. In cancer cells, Lin28a production is re-established, and as a result this natural process is disrupted.

Researchers used a series of lab tests to unravel the complex processes that are directed by the Lin28a protein. They say further studies could help explain fully the role of Lin28a and miR-9 in brain development, and pave the way to the development of novel therapies.

Dr Gracjan Michlewski of the School of Biological Sciences, who led the study, said: "Understanding more of the complex science behind the fundamental processes of cell development will helps us learn more about what happens when this goes wrong and what might be done to prevent it."


'/>"/>

Contact: Catriona Kelly
Catriona.Kelly@ed.ac.uk
44-131-651-4401
University of Edinburgh
Source:Eurekalert

Page: 1

Related medicine news :

1. Deep, integrated genomic analysis re-classifies lower-grade brain tumors
2. UCSF launches groundbreaking online registry to drive brain disease research
3. DNA modifications measured in blood signal related changes in the brain
4. Lipid levels during prenatal brain development impact autism: York U study
5. Fruitfly study: Epilepsy drug target implications for sleep disruption in brain disorders
6. Using your loaf to fight brain disease
7. Anesthetic technique important to prevent damage to brain
8. Adult cancer drugs show promise against an aggressive childhood brain tumor
9. The Brain & Behavior Research Foundation awards $4 million in NARSAD Grants
10. USF study finds stem cell combination therapy improves traumatic brain injury outcomes
11. US headache sufferers get $1 billion worth of brain scans each year, U-M study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... ... and deep lines by smoothing and tightening the skin of the face to ... to address facial aging with very little downtime, Silhouette Instalift is a novel, ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... women growing up with a schizophrenic mother in a unique, personal perspective through ... specializes in treating trauma and addictive disorders at her private psychotherapy practice. Sheri’s ...
(Date:12/7/2016)... ... December 07, 2016 , ... In the early morning of October ... emergency medical call when he lost control of his patrol car. The vehicle overturned ... vehicle, he was transported to Atlanta Medical Center, where he later succumbed to his ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... Castle Dermatology ... in several ways to restore a more youthful appearance to the face. Dr. Peyman ... Sculptra, along with a variety of other treatments, to rejuvenate and renew the facial ...
(Date:12/7/2016)... ... December 07, 2016 , ... Levels of a protein in the blood associated ... appearing online in the journal Radiology. , Heart disease and brain disease exact a ... the rapidly aging population. Damage to both organs often occurs at a subclinical stage, ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016 ... company advancing technologies designed to address rare, emerging ... Chitra Edwin , Ph.D., RAC, as Senior ... Edwin will provide leadership for all U.S. and ... approvals, preparation of regulatory submissions, serving as the ...
(Date:12/7/2016)...  Urinary catheters are used for patients suffering ... disorders. Urinary catheters include indwelling (Foley) catheter, intermittent ... Foley catheter is a flexible tube with lumens ... inserted into the bladder through the urethra and ... at one end of the catheter is inflated ...
(Date:12/7/2016)... , Dec. 7, 2016  Palatin Technologies, ... has closed on a previously disclosed underwritten public ... Canaccord Genuity acted as sole book-running manager, Roth ... Capital Markets acted as co-manager for the offering. ... $15.4 million in net proceeds, allowing us to ...
Breaking Medicine Technology: