Navigation Links
Brain cell activity regulates Alzheimer’s protein
Date:2/25/2014

Increased brain cell activity boosts brain fluid levels of a protein linked to Alzheimer's disease, according to new research from scientists at Washington University School of Medicine in St. Louis.

Tau protein is the main component of neurofibrillary tangles, one of the hallmarks of Alzheimer's disease. It has been linked to other neurodegenerative disorders, including frontotemporal dementia, supranuclear palsy and corticobasal degeneration.

"Healthy brain cells normally release tau into the cerebrospinal fluid and the interstitial fluid that surrounds them, but this is the first time we've linked that release in living animals to brain cell activity," said senior author David M. Holtzman, MD. "Understanding this link should help advance our efforts to treat Alzheimer's and other neurodegenerative disorders associated with the tau protein.

The study appears online in the Journal of Experimental Medicine.

Tau protein stabilizes microtubules, which are long columns that transport supplies from the center of the cell to the distant ends of the cell's branches. Some tau in the cell is not bound to microtubules. This tau can become altered and clump together inside brain cells, forming structures called tangles. Scientists have tracked the spread of these clumps through brain networks in animal models.

"In Alzheimer's disease, you first see clumps of tau in a region called the entorhinal cortex, and then in the hippocampus, and it continues to spread through the brain in a regular pattern," said Holtzman, the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology. "In another disorder, supranuclear palsy, tau clumps first appear in the brain stem and then spread to regions that the brain stem projects to."

These regular patterns of tau spread through brain networks have led scientists to speculate that dysfunctional tau travels to different brain regions via synapses the areas where individual nerve cells communicate with each other.

Holtzman's results support this hypothesis, showing that when nerve cells "talk" to each other, tau levels go up in the fluids between those cells, suggesting that brain cells are secreting tau when they send signals.

So far, the researchers only have been able to measure single copies of tau in brain fluid, not the tau clumps. They are looking for a way to detect the clumps. If brain cells can secrete and take in clumps of tau, the scientists believe, these clumps may cause previously normal tau in the receiving cell to become corrupted, fostering the spread of a form of tau involved in disease.

"We also want to know whether brain cells are secreting tau as waste or if tau has a function to perform outside the cell," Holtzman said. "For example, there have been hints that tau may modulate how easy or difficult it is to get brain cells to communicate with each other."


'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Related medicine news :

1. Study uncovers surprising differences in brain activity of alcohol-dependent women
2. Our brain has switch board to guide behavior in response to external stimuli
3. Rebuilding the brain after stroke
4. Grant supports Cedars-Sinai study of possible links between air pollution and brain cancer
5. Brilliant blue G may shine in treating traumatic brain injuries
6. Males and females differ in specific brain structures
7. Long distance signals protect brain from viral infections
8. Study identifies protein to repair damaged brain tissue in MS
9. Toxin from brain cells triggers neuron loss in human ALS model
10. Monkeys that eat omega-3 rich diet show more developed brain networks
11. High long-term survival of most common pediatric brain tumor, less when radiation was used
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... Sandbox, one of the ... serve in the newly created position of executive vice president, chief creative officer.     ... in the Chicago and LA offices. He reports to Nancy Finigan, president of ...
(Date:5/3/2016)... ... May 03, 2016 , ... Elizabeth Murray has always loved walking ... her with one on her shoulder and one on her arm. But she got ... of years of mitral valve prolapse. , The valves of the heart wouldn’t close ...
(Date:5/3/2016)... ... 03, 2016 , ... Excessive panting in the car or cowering when new ... often think anxiety only manifests itself as trembling or ‘tail between the legs,’ but ... that be done about it,” says Dr. Jim Lowe, technical services veterinarian for Tomlyn ...
(Date:5/3/2016)... ... 2016 , ... Diagnotes, a leader in digital healthcare communications, ... system in South Carolina, to provide its secure mobile communication platform. , “Healthcare ... drives workflow efficiencies and improves provider and patient satisfaction,” said Dr. Todd Rowland, ...
(Date:5/3/2016)... ... 2016 , ... Boston Children’s Hospital today announced its new pediatric Simulation (SIM) ... or rare procedures in an environment that looks and feels real. , Located in ... inventors and “hackers” to develop and test new devices or software platforms and see ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... , May 3, 2016  Axiogenesis has acquired a major investment from Sino-German High-Tech Fund to further expand ... Photo - http://photos.prnewswire.com/prnh/20160503/362921 ... ... ... ...
(Date:5/3/2016)... BROOMALL, Pa. , May 3, 2016 ... Attorney Jack Whelan and Delaware County ... NARCAN® (naloxone HCI) Nasal Spray in all ACME ... the U.S. Centers for Disease Control and Prevention (CDC), naloxone has ... 2014, when police officers in Delaware County ...
(Date:5/3/2016)... 2016  While you may be familiar with watching a film or TV show in high ... or 8MP in the Medical Industry.  Ampronix  is a renowned authorized reseller of the medical ... Photo - http://photos.prnewswire.com/prnh/20160502/362730 ... ... ...
Breaking Medicine Technology: