Navigation Links
Brain cancer survival improved following FDA approval of bevacizumab, Mayo study finds
Date:8/19/2013

ROCHESTER, Minn. -- A new population-based study has found that patients with glioblastoma who died in 2010, after the Food and Drug Administration (FDA) approval of bevacizumab, had lived significantly longer than patients who died of the disease in 2008, prior to the conditional approval of the drug for the treatment of the deadly brain cancer. Bevacizumab is used to treat patients with certain cancers whose cancer has spread. The study appears in the journal Cancer.

"There has been a great deal of debate about the effectiveness of bevacizumab in treating patients with glioblastoma," says lead author Derek Johnson, M.D., a neuro-oncologist at Mayo Clinic Cancer Center. "Our study found that, at the population level, treatment strategies involving bevacizumab prolonged survival in patients with progressive glioblastoma."

Researchers analyzed data on 5,607 adult patients from the National Cancer Institute (NCI) Surveillance, Epidemiology and End Results (SEER) database before and after the conditional approval of bevacizumab for the treatment of glioblastoma in 2009. The SEER database covers 18 geographic areas of the U.S., which collectively represent 28 percent of the U.S. population.

Researchers studied survival in 1,715 patients with glioblastoma who died in 2006, 1,924 who died in 2008 and 1,968 who died in 2010. "The difference in survival between 2008 and 2010 was highly significant and likely unrelated to any advancements in supportive care," Dr. Johnson says. "This study provides the strongest evidence to date that bevacizumab therapy improves survival in patients with glioblastoma."

Glioblastoma, is an aggressive cancer in which tumors grow rapidly and spread rapidly to new sites. It is the most common malignant brain tumor in adults and accounts for about 22 percent of all brain cancers. About 3,000 people develop a glioblastoma each year in the U.S.


'/>"/>

Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Epilepsy Leads to More Brain Abnormalities Over Time
3. UCLA Brain Injury Research Center gets NCAA funding for research on sports concussions
4. Why is traumatic brain injury increasing among the elderly?
5. Brain Falters Near End of Life, but Games, Puzzles Might Slow Decline
6. Dental X-Rays May Be Linked to Benign Brain Tumors
7. Nonsurgical Method to Measure Brain Pressure Shows Promise
8. Researchers Map Brain Regions Linked to Intelligence
9. Football-related catastrophic brain injuries on the rise
10. Brain Tumor Vaccine Shows Promise in Early Trial
11. Brain Surgery Might Ease Tough-to-Treat OCD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... August 29, 2015 , ... Rio Salado College joined nine ... experience as part of the EDUCAUSE - Next Generation Learning Challenges 2015 Breakthrough Models ... the third Breakthrough Models Incubator hosted by EDUCAUSE and NGLC, which is ...
(Date:8/28/2015)... ... August 28, 2015 , ... Approximately 2,000 United ... to celebrate children helping children, a thank you to the many creative and ... contributed to the United Methodist initiative to end malaria deaths. , The Columbus ...
(Date:8/28/2015)... ... August 28, 2015 , ... With the goal of furthering ... the second year to the Adams County Fairgrounds in Mendon, IL on May 30th, ... money to support music education in the underfunded school districts of Mendon and its ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... As ... from Merz, received FDA clearance for results that last for two years, the ... exciting news for patients who are looking for a long-lasting, effective solution for their ...
(Date:8/28/2015)... ... 2015 , ... Loved ones of a person suffering from ... dependency, may be able to find some hope in the latest video uploads ... addiction located in Western Michigan. Focusing on several different aspects of the powerful ...
Breaking Medicine News(10 mins):Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 3Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 4Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:Best Drug Rehabilitation Interviews Country-Rock Duo Highway Run at the 2015 "Music With A Mission" Benefit Concert 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 3Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 2Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 3
... The sickle cell trait could be a causealbeit rareof ... during football training, according to a scientific poster ... Cardiology (ACC) Scientific Sessions, April 1-3, in New Orleans. ... 8 percent of African-Americans in the U.S., has been ...
... Fla. A study published in Cancer Discovery, the ... debuting here at the AACR 102nd Annual Meeting 2011, ... in the tumor microenvironment may help researchers better target ... University of California, San Francisco, demonstrated that the level ...
... of a study presented at the AACR 102nd Annual Meeting ... that improving quality of life affects stress-related biological markers and ... that telomeres shorten and deteriorate with aging, but they are ... trying to understand the interconnections between the mind and the ...
... -- Researchers who sequenced the entire genomes of tumors ... mutations, most of which were unique to individual patients. ... predict breast cancer patient outcomes and to find new ... Louis and the Siteman Cancer Center. After sequencing ...
... Highly exciting new data presented today at the ... superior virological response in HCV patients of genotypes ... Pegylated Interferon-alpha (PegIFN-alpha-2a), the current standard of care ... so important because they show PegIFN-lambda could provide ...
... two compounds that inhibit two of the most frequently ... Phase I trial, according to data presented at the ... The research, presented by Johanna Bendell, M.D., ... GDC-0941, which inhibits PI3K. Bendell, director of Gastrointestinal ...
Cached Medicine News:Health News:Young black athletes with sickle cell trait might be susceptible to sudden death 2Health News:Immune system may guide chemotherapy for breast cancer 2Health News:Chronic stress of cancer causes accelerated telomere shortening 2Health News:Most Breast Tumors Have Unique Genetic 'Fingerprint,' Study Finds 2Health News:PegIFN-lambda shows superior virological response and improved safety than PegIFN-alpha-2a 2Health News:Combining MEK and PI3K inhibitors appears encouraging in a safety study with early signs of anti-tumor activity 2
(Date:8/28/2015)... Massachusetts and LONDON , August ... approach seamlessly connects ... continuum improving outcomes and the ...  (NYSE: PHG AEX: PHIA) today announced its presence at  ... latest cardiology solutions, including Heart Model A.I. , EchoNavigator and ...
(Date:8/27/2015)... 27, 2015  A recent study by Feucht ... compared the Arthrosurface HemiCAP® Wave implant, which is ... "onlay" design implant for isolated patellofemoral disease. While ... and pain scores, none of the patients in ... However, 53% of the patients in the "onlay" ...
(Date:8/27/2015)... , Aug. 27, 2015 ieCrowd™ ... in the commercial development of the company,s supplemental ... Smart Oxygen device, being developed by ieCrowd,s subsidiary ... a patient,s changing demand for oxygen based on ... 510 (k) submission for the Smart Oxygen device ...
Breaking Medicine Technology:Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 2Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 3Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 4Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 2Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 3Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 2Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 3Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 4
... Israel, August 31, 2011 Elbit Imaging Ltd. ... for the second quarter of 2011. Consolidated revenues ... to NIS 241 million (US$ 71 million) compared to NIS 573 ... decrease is mainly attributable to: (i) we reported non-recurring gain from ...
... EXTON, Pa., Aug. 30, 2011 Kensey Nash Corporation ... at the following investor conferences in September. ... Growth Conference 2011 in Chicago on Wednesday, September 7th, ... company,s website ( www.kenseynash.com ) at 8:00 a.m. ET ...
Cached Medicine Technology:Elbit Imaging Ltd. Announces Second Quarter Results for 2011 2Elbit Imaging Ltd. Announces Second Quarter Results for 2011 3Elbit Imaging Ltd. Announces Second Quarter Results for 2011 4Elbit Imaging Ltd. Announces Second Quarter Results for 2011 5Elbit Imaging Ltd. Announces Second Quarter Results for 2011 6Elbit Imaging Ltd. Announces Second Quarter Results for 2011 7Elbit Imaging Ltd. Announces Second Quarter Results for 2011 8Elbit Imaging Ltd. Announces Second Quarter Results for 2011 9Elbit Imaging Ltd. Announces Second Quarter Results for 2011 10Kensey Nash Investor Conference Schedule 2
... a 32 kDa glycoprotein secreted by the ... [1]. The structure of human TSH is ... placental gonadotropins, consisting of an a-subunit which ... and a unique beta-subunit, which confers hormonal ...
... Triiodothyronine (T3) is produced primarily by 5-monodeioination ... the thyroid gland, T3 production occurs at ... that for T4. Release of T3 from ... ~5-8 micrograms/day as compared to 80-100 micrograms/day ...
... factor binding protein-3 (IGFBP-3) is the main binding ... as a component of the ~150 kDa ternary ... of IGF-I or IGF-II and ALS, allowing IGFBP-3, ... the IGFs. The molar concentration of IGFBP-3 in ...
... Growth hormone (GH) is a monomeric ... the anterior pituitary gland. GH is released ... a pulsatile manner under the regulatory control ... (GHRF) [1]. The timing and frequency of ...
Medicine Products: