Navigation Links
Brain cancer study: Magnitude of post-vaccine immune response linked to clinical outcomes
Date:7/14/2008

to believe that while T-cell activity may not result in net destruction of the tumor it is fundamentally changing the tumor into one that is predominantly comprised of chemosensitive cells rather than chemoresistant cells."

The findings also appear to give scientists a way to more quickly evaluate future vaccine-related research.

"The demonstration that the magnitude of immune response is directly related to survival of patients gives us a very good tool or 'surrogate marker' for clinical benefit. If we can improve the immune response of our vaccine, we can anticipate that the clinical benefit will be improved as well. This allows us to fine-tune our vaccine in more of a real-time way," said John S. Yu, M.D., director of Surgical Neuro-oncology at Cedars-Sinai, principal investigator of the clinical trial and senior author of the article.

This study centered on the immune responses of 32 patients enrolled in a Phase II clinical trial. Seventeen patients had a significant positive response after three vaccinations; 15 showed no such responsiveness. Average time to tumor progression (based on when tumor volume increased by about 25 percent on MRI scans) was about 308 days among responders, compared to 167 days for non-responders. Average length of survival (based on date of death or date of last contact with surviving patients) was about 642 days (about 21 months) among responders, compared to 430 days (about 14 months) for non-responders.

Forty-one percent of vaccine responders, compared to seven percent of non-responders, survived at least two years. All patients in the trial had longer time to progression and longer time of survival, on average, than patients undergoing standard treatment without vaccination, although their pre-vaccine disease courses were similar.

The vaccine was first used experimentally in patient treatment in May 1998, and numerous studies have been conducted to fine-tune the therapy and combine it
'/>"/>

Contact: Sandy Van
sandy@prpacific.com
800-880-2397
Cedars-Sinai Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Exercise Might Slow Brain Shrinkage in Alzheimers Patients
2. Researchers hone technique to KO pediatric brain tumors
3. Researchers link Huntingtons disease to overactive immune response in the brain
4. Dartmouth research reveals passive learning imprints on the brain just like active learning
5. Posit Science Corporation Releases the Brain Fitness Program Classic(TM) for Mac OS X
6. Aging Brain Can Learn New Tricks
7. Rutgers research identifies brain cells related to fear
8. UAB joins elite brain cancer research group
9. Neurogenesis in the adult brain: The association with stress and depression
10. UF McKnight Brain Institute director honored by Italian scientists
11. Alcoholism-associated molecular adaptations in brain neurocognitive circuits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... (PRWEB) , ... July 01, ... ... in the communities of southeast Alabama, southwest Georgia and the Florida Panhandle, ... TelmedIQ as its primary secure text messaging and clinical communications workflow solution ...
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... ... the legal medical cannabis space, created a web-based resource where legal cannabis ... Harvest Financial brings together visionary entrepreneurs and medical marijuana advocates looking to strategically ...
(Date:7/1/2015)... ... ... Effective June 9, 2015, the Radiology Business Management Association (RBMA) ... process has been in place since the RBMA was founded in 1968 with all ... succeeds Keith E. Chew, MHA, CMPE, as president. Ms. Taylor has been an RBMA ...
(Date:6/30/2015)... , ... July 01, 2015 , ... Carey Danis ... lawsuits being managed in a West Virginia federal court. The court document outlined ... trial date for the 26 cases.¹ , Carey Danis & Lowe is a personal ...
(Date:6/30/2015)... ... ... Down is a reputable source of authentic Kid Rock tickets at the DTE Energy ... road again this summer in what is one of the most affordable summer tours in ... this year at the XFINITY Theatre in Hartford, CT on June 24th and the blockbuster ...
Breaking Medicine News(10 mins):Health News:Southeast Alabama Community Health System Chooses TelmedIQ to Meet Secure Text Messaging Challenges for Healthcare 2Health News:First Harvest Financial Partners in Launch of Legal Medical Cannabis Documentary Initiative 2Health News:First Harvest Financial Partners in Launch of Legal Medical Cannabis Documentary Initiative 3Health News:Radiology Business Management Association Announces Board of Directors and Officers for 2015-2016 2Health News:Radiology Business Management Association Announces Board of Directors and Officers for 2015-2016 3Health News:Radiology Business Management Association Announces Board of Directors and Officers for 2015-2016 4Health News:Carey Danis & Lowe Comments on New Pretrial Order in Vaginal Mesh Lawsuit 2Health News:Carey Danis & Lowe Comments on New Pretrial Order in Vaginal Mesh Lawsuit 3Health News:Cheap Kid Rock Tickets at the DTE Energy Music Theatre in Clarkston: Ticket Down Has Slashed Prices On All Kid Rock Tickets at DTE in the Detroit Metro Area 2
... 2,000,000 Minnesotans have designated their wishes to donate,on their ... April 1, 2008 When,Minnesotans apply for or renew ... with the opportunity to check the,box designating themselves organ ... taken that important step and said yes to the,life-saving ...
... CA, April 1, 2008 Rap music has gone from ... substance abuse to one that often glorifies illegal drug use, ... genre covering nearly two decades. The study is published ... a peer reviewed scientific journal., Positive portrayals of drug use ...
... protein helps virus conceal itself from body,s defenses , , ... discovered how HIV -- the virus that causes AIDS -- ... body,s immune cells. , They explained that when a normal ... immune system responds and produces cells that quickly eliminate the ...
... With Melanin-Rich Skin Tones, SKILLMAN, N.J., April 1, 2008 ... skin tones between,the ages of 25 and 54 experience dry ... only skin concern for these women. Women with,richer skin tones ... due to the excess melanin in their skin that often ...
... NEW YORK, April 1 SpongeTech Delivery,Systems, Inc. ... Darryl,Strawberry Foundation are pleased to announce corporate involvement ... for the New,York Mets, I am excited about ... have been a great tool for children with,autism, ...
... April 1, 2008 Valensa International,introduced Crannose(TM) ... Natural Products Expo West Conference. This patent-pending,supplement, ... known benefits of cranberry with D-mannose, a ... Larch tree. The,product is available in bulk, ...
Cached Medicine News:Health News:Minnesotans Demonstrate Commitment to Organ and Tissue Donation 2Health News:Drug use increasingly glamorized in rap music, according to new study of 2-decade trends 2Health News:Drug use increasingly glamorized in rap music, according to new study of 2-decade trends 3Health News:Scientists Uncover How HIV Hides Inside Cells 2Health News:AMBI(R) Introduces SOFT & EVEN(TM) 2Health News:AMBI(R) Introduces SOFT & EVEN(TM) 3Health News:SpongeTech Delivery Systems, Inc. to Donate to The Darryl Strawberry Foundation!! 2Health News:Crannose(TM) Extra Strength Women's Health Formula Targets Urinary Tract Infections 2
(Date:6/30/2015)... 30, 2015 Oramed Pharmaceuticals Inc. ... pharmaceutical Company focused on the development of oral drug ... been screened in the Company,s Phase IIb trial of ... will be performed under the active Investigational New Drug ... Drug Administration (FDA). The Phase IIb study ...
(Date:6/30/2015)... , June 30, 2015  July 4 th ... of independence, and the spirit and people behind it. To ... has partnered with USA Medical Card, ... increase funding for programs that empower independence for our disabled ... and help more people afford their prescriptions. "Due ...
(Date:6/30/2015)... June 30, 2015  EnteroMedics Inc. (NASDAQ: ETRM ... neuroblocking technology to treat obesity, metabolic diseases, and other ... public offering  of 40,229,886 units. Each unit consists of ... A warrant to purchase one share of common stock, ... one share of common stock, at a purchase price ...
Breaking Medicine Technology:Oramed Enrolls First Patient in its Phase IIb Oral Insulin Study 2Oramed Enrolls First Patient in its Phase IIb Oral Insulin Study 3Hope For Heroes and USA Medical Card Make a Difference for Our Nation's Heroes 2EnteroMedics Inc. Announces Pricing of $35.0 Million Public Offering of Common Stock and Warrants 2EnteroMedics Inc. Announces Pricing of $35.0 Million Public Offering of Common Stock and Warrants 3
... 3 Australian researchers have developed gene expression ... colorectal growths from non-cancerous controls. , , ... conference in Chicago, the preliminary findings are the ... Flinders University and Australian healthcare company, Clinical Genomics ...
... Day 3 And All Subsequent Study Visits - , ... Pharma Co., Ltd., (DSP) announced today that positive results from ... of patients with schizophrenia have been published in The ... placebo-controlled trial, involving 180 patients with acute schizophrenia, evaluated a ...
Cached Medicine Technology:Advance in Bowel Cancer Test Research 2Study Demonstrating Lurasidone Is Effective in Patients With Schizophrenia Published in The Journal of Clinical Psychiatry 2Study Demonstrating Lurasidone Is Effective in Patients With Schizophrenia Published in The Journal of Clinical Psychiatry 3Study Demonstrating Lurasidone Is Effective in Patients With Schizophrenia Published in The Journal of Clinical Psychiatry 4
Used for internal biliary drainage. Supplied sterile in peel-open packages. Intended for one-time use....
... Marker directly to the biopsy site helps ... performed. ,The MICROMARK® II Tissue Marker is ... for use with the MAMMOTOME Biopsy System. ... site after a biopsy with the MAMMOTOME ...
... wrap than VICRYL knitted mesh. Especially suitable ... contained. Predictable absorption. Polyglactin 910 has been ... ,VICRYL (polyglactin 910) woven mesh is prepared ... and lactide, derived respectively from glycolic and ...
Used for implantation to reinforce soft tissue. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: