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Brain cancer: Study focuses on forgotten cells
Date:4/13/2010

Glioblastoma is a guileful enemy. While most of the brain tumor can often be removed surgically, in virtually every case the tumor reappears. One reason for this is that sporadic, infiltrative tumor cells will remain in the brain even after most careful surgery. Researchers at the University of Bonn have now subjected these 'forgotten' cells to closer scrutiny for the first time. While doing this, they were able to show that many of the fundamental properties of these tumor cells were substantially different from the cells in the midst of the tumor mass. The findings could offer an opportunity to explain why radiation or chemotherapy cannot entirely prevent this deadly disease to reoccur. The study will now be published in the Annals of Neurology (DOI: 10.1002/ana.22036).

Patients with a glioblastoma generally undergo surgery as quickly as possible. During the process, starting from the center of the tumor, the neurosurgeon gently removes diseased tissue until the tumor appears to be removed entirely. Unfortunately, the cancer cells are hard to get hold of. They often migrate far into adjacent, healthy brain tissue. That is why there are basically always some malignant cells remaining after every surgery, from which then new tumors are formed.

The Bonn scientists have now taken a closer look at these residual cells for the first time.

Apart from being provided with samples from the main mass of the tumor for their research, the scientists were also provided with small diagnostic samples from adjacent tissue from 33 patients by the University of Bonn Department of Neurosurgery. 'From the small samples we then extracted and enriched the few tumor cells that would have normally remained in the patient.' Professor Bjrn Scheffler from the Institute of Reconstructive Neurobiology explains.

Astonishing discovery

While examining these residual cells, the researchers made an astonishing discovery. 'The cancer ce
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Contact: Dr. Bjrn Scheffler
bscheffler@uni-bonn.de
49-022-868-85473
University of Bonn
Source:Eurekalert

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