Navigation Links
Brain cancer: Hunger for amino acids makes it more aggressive
Date:6/24/2013

To fuel phases of fast and aggressive growth, tumors need higher-than-normal amounts of energy and the molecular building blocks needed to build new cellular components. Cancer cells therefore consume a lot of sugar (glucose A number of tumors are also able to catabolize the amino acid glutamine, an important building block of proteins. A key enzyme in amino acid decomposition is isocitrate dehydrogenase (IDH). Several years ago, scientists discovered mutations in the gene coding for IDH in numerous types of brain cancer. Very malignant brain tumors called primary glioblastomas carry an intact IDH gene, whereas those that grow more slowly usually have a defective form.

"The study of the IDH gene currently is one of the most important diagnostic criteria for differentiating glioblastomas from other brain cancers that grow more slowly," says Dr. Bernhard Radlwimmer from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ). "We wanted to find out what spurs the aggressive growth of glioblastomas." In collaboration with scientists from other institutes including Heidelberg University Hospital, Dr. Martje Tnjes and Dr. Sebastian Barbus from Radlwimmer's team compared gene activity profiles from several hundred brain tumors. They aimed to find out whether either altered or intact IDH show further, specific genetic characteristics that might help explain the aggressiveness of the disease.

The researchers found a significant difference between the two groups in the highly increased activity of the gene for the BCAT1 enzyme, which in normal brain tissue is responsible for breaking down so-called branched-chain amino acids. However, Radlwimmer's team discovered, only those tumor cells whose IDH gene is not mutated produce BCAT1. "This is not surprising, because as IDH breaks down amino acids, it produces ketoglutarate a molecule which BCAT1 needs. This explains why BCAT1 is produced only in tumor cells carrying intact IDH. The t
'/>"/>

Contact: Dr. Sibylle Kohlstädt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Salk scientists discover previously unknown requirement for brain development
2. American Brain Tumor Association’s 2013 Patient & Family Conference Aims to Engage and Empower
3. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Now Help Patients Lose Weight Fast and Reap Weight Loss Benefits Like Increased Brain Activity and Memory Function
4. Voices Against Brain Cancer Awards Grant to Tocagen to Support Investigation of Toca 511 & Toca FC in Patients with Recurrent Brain Cancer
5. Virus combination effective against deadly brain tumor, Moffitt Cancer Center study shows
6. RKNet Studio Launched Online Website for Fun Games, Brain Training and Cognitive Skills Development
7. Brain Not Working? Minor Symptoms Now Could Mean MS, Alzheimer's, or Parkinson's Later
8. Long-term study reports deep brain stimulation effective for most common hereditary dystonia
9. New Alzheimers research suggests possible cause: The interaction of proteins in the brain
10. American Brain Tumor Association Conference Advances Holistic Approach to Living with a Brain Tumor
11. Its the way you tell em: Study discovers how the brain controls accents and impersonations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... The print component of Mental Health is distributed within ... approximately 327,720 copies and an estimated readership of 688,212. ... social media strategy and across a network of top ... version of the campaign, visit http://mentalhealthnews.ca/ . , ... host of TSN’s Off the Record. Landsberg, who battles ...
(Date:9/23/2014)... Antibiotics revolutionized health care in the early ... thousands of people. But bacteria are also constantly ... are popping up more frequently. This week,s Speaking ... new antibiotics and discusses the prospects for new ... should you finish your pills if you feel ...
(Date:9/23/2014)... Contrary to what is often assumed about single parents, ... from The Kinsey Institute has found that single parents ... active as often as singles without children -- and ... The study, "Dating and Sexual Behavior Among Single Parents ... online in the Journal of Sex Research ...
(Date:9/23/2014)... On September 23, 2014, My Positive Perspective founder ... Simmons is the founder of Traveler of Charleston magazine and ... to know. At the start of the interview, Deierlein asked ... magazine?” Simmons replied by saying, “I had worked for the ... quit that and decided to start my own magazine thinking ...
(Date:9/23/2014)... September 20- 21, 2014, people from all over the ... Retreat ‘Consciousness is Power’, online as well as in-person ... Mahendra Trivedi and Trivedi Masters™ Dahryn Trivedi and Alice ... group and live Energy Transmissions and also listened to ... Alice Branton, where, they described about the importance of ...
Breaking Medicine News(10 mins):Health News:‘Sick, not weak’: Mediaplanet’s "Mental Health” Campaign Dispels Stigmas and Bolsters Support for the One in Five Canadians Suffering Mental Illness 2Health News:Kinsey study of single parents' dating, sexual activity contradicts assumptions 2Health News:My Positive Perspective Airs Episode With the Founder of Traveler of Charleston Magazine 2Health News:The Trivedi Retreat ‘Consciousness is Power’ was Huge Success 2Health News:The Trivedi Retreat ‘Consciousness is Power’ was Huge Success 3
... ... an Austin, TX based scrubs manufacturer, has posted their client ratings to their website. ... Austin, TX (PRWEB) September 16, ... posted their client ratings to their website. "Ratings help potential clients make decisions on ...
... SEATTLE, Sept. 16 Cell Therapeutics, Inc. (CTI) (Nasdaq and ... conference on Wednesday, September 16, 2009, at 10:30 AM Eastern. , ... the Millennium Broadway Hotel in New York. , The conference ... presentation. The webcast can be accessed at www.celltherapeutics.com . ...
... NEW YORK, Sept. 15 The following was released today ... the United States who are concerned about the ongoing accusations of an ... the hospital,s Manhattan office at 50 W. 58th St. this Wednesday, September ... now three and a half years of age, was hospitalized at Hadassah ...
... ... of The ALS Association’s inaugural Partnership for Success Award for the firm’s longtime support ... ... Hamilton, a leading business strategy and technology consulting firm, is the recipient of The ...
... , , SAN DIEGO, Sept. 15 ... BMR ) today announced that its board of directors has declared a ... The dividend is equivalent to an annualized dividend of $0.44 per common ... board of directors has declared a dividend of $0.46094 per share of ...
... , , , , ... Awareness Calendar , , LOCAL CALENDAR ... many more celebrities featured with local Austin children in 2010 Down Syndrome ... Sept 15 The Down Syndrome Association of Central Texas, (DSACT) ...
Cached Medicine News:Health News:Clients Post 5-Star Product Reviews at blue sky scrubs 2Health News:Clients Post 5-Star Product Reviews at blue sky scrubs 3Health News:Clients Post 5-Star Product Reviews at blue sky scrubs 4Health News:American Jews to Protest Against Hadassah Hospital 2Health News:The ALS Association Honors Booz Allen Hamilton With the Inaugural Partnership for Success Award 2Health News:The ALS Association Honors Booz Allen Hamilton With the Inaugural Partnership for Success Award 3Health News:The ALS Association Honors Booz Allen Hamilton With the Inaugural Partnership for Success Award 4Health News:The ALS Association Honors Booz Allen Hamilton With the Inaugural Partnership for Success Award 5Health News:BioMed Realty Trust Declares Third Quarter 2009 Common Stock and Preferred Stock Dividends 2Health News:'Share the Passion' Photography Exhibition & Red Carpet Gala 2Health News:'Share the Passion' Photography Exhibition & Red Carpet Gala 3
(Date:9/23/2014)... , Sept. 23, 2014 Today, DripDrop, ... announced the formation of the DripDrop Foundation, with ... preventable dehydration worldwide. Utilizing scientific advancements in Oral ... solutions to reduce dehydration and healthcare costs through ... missions. "DripDrop has been used ...
(Date:9/23/2014)... Wash. , Sept. 23, 2014   BioLife ... leading developer, manufacturer and marketer of proprietary clinical grade ... media and precision thermal shipping products for ... two new additions to its Scientific Advisory Board.  The ... Anthony Davies , PhD. Dr. Acker ...
(Date:9/22/2014)... -- , La tecnología basada en ... satisfagan el creciente rigor de las autoridades sanitarias en ... permanentes de ensayo (TMF, por sus siglas en inglés) ... el sector de las ciencias biológicas hasta la fecha ... ensayos clínicos que planean proporcionar a los auditores acceso ...
Breaking Medicine Technology:DripDrop Forms Foundation To Scale Relief Efforts 2BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 2BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 3BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 4BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 5BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 6BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 7El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 2El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 3El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 4El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 5
... April 19, 2011 Genetic Technologies Limited ... preliminary research collaboration agreement to jointly develop a new ... pharmaceutical companies. Under the collaboration Genetic ... work with this world-leading pharmaceutical company to develop specific ...
... April 19, 2011 If your medicine has expired, ... this Consumer Update video, FDA pharmacist Ilisa Bernstein explains ... to use and will work as intended. ... http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm251658.htm Sign up for e-mail notices ...
Cached Medicine Technology:GTG Announces New Product Collaboration with Global Pharmaceutical Company for Companion Diagnostics in Oncology 2
... a sterile, single use bundle of absorbent matrix ... The synthetic matrix absorbs excess exudate fluid, swells ... slough and necrotic debris within its strands to ... matrix are bound together by a matrix bridge ...
A non-adhering hydrogel sheet dressing for use on all partial and full thickness wounds (excluding 3rd degree burns.) Hydrogel sheet contains 96% water and 4% insoluble cross-linked polyethylene oxid...
... offers for purchase a comprehensive Clinical ... highly recommends the implementation of this ... facility's clinical, financial and patient accounting ... provides the benefit of streamlined processes ...
... provides easy, intuitive routines for quick set ... multifacility features along with unparalleled integration provide ... usage calculates charges, bills patients, decrements inventory ... minute. The system's many powerful features enable ...
Medicine Products: