Navigation Links
Brain Scan May Help Predict Cancer Drug Response

Identifying tumors treatable with Avastin has multiple benefits, researchers say,,

THURSDAY, July 30 (HealthDay News) -- A new way to predict which brain cancer patients will respond to the drug Avastin has been developed by U.S. researchers.

Avastin, which shrinks tumors by cutting off their blood supply, was approved this spring by the U.S. Food and Drug Administration for treatment of aggressive brain cancer. However, half of those with the cancer don't respond to the drug, which can cost up to $10,000 a month, according to a news release from the University of California, Los Angeles.

UCLA researchers examined 82 people who had surgery and radiation to treat glioblastoma, the most common and deadly form of adult brain cancer. Half of them were given infusions of Avastin every two weeks, and all had monthly MRI brain scans to monitor changes.

An analysis of the scans showed that there was greater water movement in the tumors of people who later had the best response to Avastin. By using MRI to measure the amount of water motion within the tumor, the researchers were able to predict with 70 percent accuracy which tumors would progress within six months and which would not.

Increased water movement in tumors is linked with higher levels of a growth factor called VEGF, which is secreted by a tumor to promote the growth of new blood vessels that provide the tumor with oxygen and nutrients. Avastin blocks VEGF, the researchers explained.

"When we realized that high levels of VEGF are linked to greater cell death and increased water movement, we were able to predict the patients' response to Avastin before they began treatment," lead author Dr. Whitney Pope, assistant professor of radiological sciences at UCLA's David Geffen School of Medicine, said in the news release.

"We were correct 70 percent of the time," Pope said. "Previously, identifying which patients would respond was like flipping a coin. This is a huge improvement."

The study appears in the July issue of Radiology.

"Knowing this information ahead of time will help doctors personalize therapy for each patient and decrease exposure to side effects," Pope said.

He and a co-author are consultants for Genentech, which makes Avastin, and are working with the company on several research studies.

More information

The U.S. National Cancer Institute has more about brain tumors.

-- Robert Preidt

SOURCE: University of California, Los Angeles, news release, July 30, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Vision restoration therapy shown to improve brain activity in brain injured patients
3. Clinical depression linked to abnormal emotional brain circuits
4. Brain imaging reveals breakdown of normal emotional processing
5. Brain cells work differently than previously thought
6. Vaccine Stops Alzheimers Brain Tangles
7. Research may unlock mystery of autisms origin in the brain
8. Scientists Spot Brains Free Will Center
9. Free will takes flight: how our brains respond to an approaching menace
10. Alcoholics With Cirrhosis Have More Brain Damage
11. Brain Lesions Predict MS Progression
Post Your Comments:
Related Image:
Brain Scan May Help Predict Cancer Drug Response
(Date:12/1/2015)... N.C. (PRWEB) , ... December 01, 2015 , ... The ... to drive awareness and funds for Multiple System Atrophy (MSA) research, timed today to ... Atrophy takes many things from patients including their ability to work and be productive, ...
(Date:12/1/2015)... ... December 01, 2015 , ... The North American Meat Institute ... meat and poultry play in a healthy, balanced diet. , includes a ... can check their “meat IQ,” a section offering straight talk on controversies, information ...
(Date:12/1/2015)... , ... December 01, 2015 , ... World Patent ... Multi Jar, a container patent that allows for easier packing and organizing of items ... is worth $90 billion," says Scott Cooper, CEO and Creative Director of World Patent ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... ... area in rural West Tennessee to receive Gigabit Internet through a partnership this ... of America’s largest cities, Henderson is an attractive destination for entrepreneurs who want ...
(Date:12/1/2015)... ... ... ClinicoEconomics and Outcomes Research has published the ... ”. , As corresponding author Dr Ankita Modi says “Pre-existing gastrointestinal events may ... a large US managed care database, women aged 55 years or older with ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... VANCOUVER , Dec. 1, 2015 /PRNewswire/ ... Pharmaceuticals, Inc. (NASDAQ: OGXI ) announced today that ... the pre-planned interim futility analysis of the intent-to-treat (ITT) ... issues were identified by the DMC. Both the DMC ... results are expected in the second half of 2016, ...
(Date:12/1/2015)... -- As enforcement of the Food and Drug ... approaches, InfiniTrak announced today new partnerships ... looming FDA regulations. --> ... with State Pharmacy Associations, an independent pharmacist association, ... exclusively provide the InfiniTrak track-and-trace software solution to ...
(Date:12/1/2015)... ) ... "Medium Molecular Weight Polyisobutylene Market for Gum ... - Global Industry Analysis, Size, Share, Growth, ... report to their offering. --> ... the "Medium Molecular Weight Polyisobutylene Market ...
Breaking Medicine Technology: