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Brain Region Tied to Amphetamine Addiction
Date:10/25/2007

aking amphetamines. However, their craving for amphetamines returned when the insula went back into action.

In a second experiment, the rats received injections of lithium, a drug used to treat mood disorders that can cause gastrointestinal discomfort. The malaise promptly appeared under normal conditions but not when the rats' insulas were inactivated just before the lithium shots.

The Chilean researchers said they plan human trials to confirm what has been seen in the animal studies. They also plan more animal work to see if they can prevent amphetamine craving for longer periods and perhaps alleviate other distressing symptoms of amphetamine addiction.

More information

There's more on drug addiction at the U.S. National Institute on Drug Abuse.



SOURCES: Robert Vorel, M.D., Ph.D, fellow, division of drug abuse, Columbia University Medical Center, New York; Oct. 26, 2007, Science


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