Navigation Links
Brain Region Tied to Amphetamine Addiction
Date:10/25/2007

When the insula was switched off, rats lost the craving, scientists say

THURSDAY, Oct. 25 (HealthDay News) -- A specific brain region may be crucial to drug addiction, according to a new study conducted with amphetamine-addicted rats.

"This work in rats lines up nicely with new findings in humans involved with drug-seeking behavior," said one outside expert, Dr. Robert Vorel, a fellow at Columbia University Medical Center's division of drug abuse in New York City.

The brain segment, called the insular cortex, "may be a key structure in decision-making by informing the executive prefrontal cortex of our needs -- as in the case of drug abuse," study lead author Dr. Fernando Torrealba, a neuroscientist at the Pontifical Catholic University of Chile, in Santiago, said in a statement.

The insular cortex, also known as the insula, is part of the sensory system that monitors the body's perception of physical states and needs. The new study shows that the insula "may guide behavior in humans," Torrealba said.

Prior studies done in humans looked at the role of the insula in nicotine craving. They revealed insula activity in smokers exposed to tobacco fumes, Vorel said.

And he added that other work has studied people who suffered brain injuries. They showed that smokers who had strokes that damaged the insula were most likely to give up smoking. "That raised a lot of attention," Vorel said.

The new Chilean work on amphetamines and the insula, "probably confirms what is already known in humans," Vorel said.

The Chilean researchers worked with amphetamine-addicted rats. In one series of studies, insular cortex activity was silenced by injections of a drug that inactivated brain cells in the area. When that happened, the rats stopped seeking amphetamines and returned to their normal behaviors -- for example, going to a dark compartment rather than the brighter region they favored while taking amphetamines. However, their craving for amphetamines returned when the insula went back into action.

In a second experiment, the rats received injections of lithium, a drug used to treat mood disorders that can cause gastrointestinal discomfort. The malaise promptly appeared under normal conditions but not when the rats' insulas were inactivated just before the lithium shots.

The Chilean researchers said they plan human trials to confirm what has been seen in the animal studies. They also plan more animal work to see if they can prevent amphetamine craving for longer periods and perhaps alleviate other distressing symptoms of amphetamine addiction.

More information

There's more on drug addiction at the U.S. National Institute on Drug Abuse.



SOURCES: Robert Vorel, M.D., Ph.D, fellow, division of drug abuse, Columbia University Medical Center, New York; Oct. 26, 2007, Science


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Brain death – How to cope with it
3. Multi billion-dollar suit filed against cell phone firm for causing brain tumours
4. “Brain fingerprinting”- The new lie detectr
5. Nasal Spray Could Take Drugs Direct to Brain.
6. Two doctors suspended for wrong brain surgery
7. The brain loves a surprise
8. Virus Combats Brain Tumour
9. Increase in sugar...decrease in brain function!!!
10. Alcohol shrinks brain
11. Roller coaster takes brain for a big ride!!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... ... and related services to families and business owners in and around Lackawanna County, ... benefit senior citizens in the area. , Meals on Wheels of NEPA provides ...
(Date:6/22/2017)... ... June 22, 2017 , ... Branches, Inc. has been partnering with ... grant funding to support its programs focused on providing opportunity to low-income families and ... grant by the Foundation of $15,000 to support its , Climb to College & ...
(Date:6/22/2017)... ... June 23, 2017 , ... Despite its pervasiveness, many physicians are unfamiliar ... integrate basic science with clinical practice. Now, however, a timely review has been published ... insight into the etiology of NeuP and educating preclinical scientists on its diagnosis and ...
(Date:6/20/2017)... , ... June 20, 2017 , ... ... announced today that Claritas Capital, a Nashville-based private equity firm, has invested $3.35 ... expansion plans for some time, and Claritas Capital offers the smart money, speed ...
(Date:6/20/2017)... ... June 20, 2017 , ... Hayes, ... published a new eBook titled “ 5 Questions to Ask Before Entering the ... on the Genetic Test Evaluation (GTE) team, the book explores the various types ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... Calif. , June 14, 2017 The ... the City of Fremont and ... of the bio-pharma industry in California ... technology, enabling executive networking, and fostering workforce development. The ... development and growth of start-ups, as well as small ...
(Date:6/12/2017)... , June 12, 2017 Kineta, Inc., a ... announced Kineta Vice President of R&D and Head ... the Pandemic Preparedness for the Northwest and Beyond ... held on June 14, 2017 from 8:30-10:30 AM PDT at ... Dr. Bedard will be joined by ...
(Date:6/9/2017)... AirXpanders, Inc. (ASX: AXP) (AirXpanders or Company), ... sale and distribution of the AeroForm® Tissue Expander System, ... commercial roll-out in the United States ... hundred (100) medical institutions and health systems, located throughout ... alternative for women who choose reconstructive surgery following a ...
Breaking Medicine Technology: