Navigation Links
Brain Protein May Be a Clue to Autism
Date:12/5/2007

Early research suggests trouble in nervous system development

WEDNESDAY, Dec. 5 (HealthDay News) -- Problems involving a brain protein called CASK and an enzyme called Cdk5 may be part of the cause of autism and other brain disorders, say researchers at Massachusetts Institute for Technology's Picower Institute for Learning and Memory.

CASK plays a major role in the development of synapses, which send and receive signals between neurons and underlie the ability to learn and remember. Improperly formed synapses can cause mental retardation, and mutations in genes encoding certain synaptic proteins are associated with autism, according to background information in the study.

In this study, the MIT researchers looked at how a kinase (an enzyme that change proteins) called Cdk5 interacts with CASK.

"We found that Cdk5 is critical for recruiting CASK to do its job for developing synapses," Li-Huei Tsai, a professor of neuroscience, said in a prepared statement. "Without Cdk5, CASK was not in the right place at the right time, and failed to interact with essential presynaptic components. This, in turn, led to problems with calcium influx."

The flow of calcium in and out of neurons affects the nervous system's development and its ability to change in response to experience.

"There are still a lot of unknowns. Causes for psychiatric disorders are still very unclear, but accumulating evidence strongly suggests that alterations in the synaptogenesis program can lead to these serious diseases," Tsai said.

The study appears in the Dec. 6 issue of the journal Neuron.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about autism.



-- Robert Preidt



SOURCE: MIT news release, Dec. 5, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Vision restoration therapy shown to improve brain activity in brain injured patients
3. Clinical depression linked to abnormal emotional brain circuits
4. Brain imaging reveals breakdown of normal emotional processing
5. Brain cells work differently than previously thought
6. Vaccine Stops Alzheimers Brain Tangles
7. Research may unlock mystery of autisms origin in the brain
8. Scientists Spot Brains Free Will Center
9. Free will takes flight: how our brains respond to an approaching menace
10. Alcoholics With Cirrhosis Have More Brain Damage
11. Brain Lesions Predict MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... Hills, CA (PRWEB) , ... April 29, 2016 , ... ... of devices and products for the head and neck/ear, nose and throat specialty, has ... Device , The KOTLER NASAL AIRWAY™ is a newly patented safety device ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... growth round of funding led by Eastside Partners, with participation from existing investor ... growing customer base and accelerate its technology and product roadmap. , ...
(Date:4/29/2016)... ... April 29, 2016 , ... Regenerative Medicine Solutions (RMS) scored 94.8124 ... survey, earning them second place for Tampa’s Best Places to Work. They were ranked ... is a great accomplishment for our team,” says RMS Human Resources Manager Irene Miller. ...
(Date:4/29/2016)... ... April 29, 2016 , ... The infertility specialists at HRC Fertility/Orange County (HRC/OC) ... Daniel A. Potter -- are proud of the recent release of their 2014 in ... SART published the latest verified data for 375 U.S. member clinics. *Preliminary ...
(Date:4/29/2016)... ... April 29, 2016 , ... Natren, Inc. recently sent representatives ... Petbiotics ™, as they fondly call them. As animal lovers, they were ... their non-profit organizations. Animal rescues across the nation face huge hurdles rescuing animals ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... Calif. , April 29, 2016  In ... is projected to shift from systems dependent on ... all types of modality CRT Medical monitors and ... there are a host of foreseeable benefits to ... concern; will existing modalities have to be replaced ...
(Date:4/29/2016)... 2016 ReportsnReports.com adds "Pulmonary ... research report that provides an overview of the ... various stages, therapeutics assessment by drug target, mechanism ... molecule type, along with latest updates, and featured ... players involved in the therapeutic development for Pulmonary ...
(Date:4/29/2016)... April 29, 2016 Acquisition ... Sciences, Product Development Capabilities in North ... Base . Indegene ( http://www.indegene.com ... the acquisition of Skura Corporation,s life science business. ... adaptive sales enablement technology for life science organizations ...
Breaking Medicine Technology: