Navigation Links
Brain Mechanism Can Turn Off Trauma of Bad Memories
Date:7/30/2008

Molecules that eliminate fear factor could lead to new panic disorder drugs

WEDNESDAY, July 30 (HealthDay News -- The brain mechanism that turns off traumatic feelings associated with bad memories has been identified by researchers at the University of California, Irvine, who said their finding may lead to the development of new drugs to treat panic disorders.

When a person suffers a traumatic experience, environmental cues often become associated with the bad experience. Subsequent exposure to the same cues can cause fear or even panic attacks, according to study author Rainer Reinscheid, an associate professor of pharmacology and pharmaceutical sciences.

The UCI team, along with colleagues from the University of Muenster in Germany, found that a protein called neuropeptide S (NPS) eliminates traumatic responses to bad memories by working on a group of neurons inside the amygdala, the brain region where negative memories are stored.

In experiments with mice exposed to situations that caused bad memories, the researchers found that blocking NPS receptors in the amygdala made traumatic responses to bad memories persist longer. But when the mice were treated with compounds that activated the NPS receptors, traumatic responses vanished sooner.

The findings are published in the July 31 issue of Neuron.

"The exciting part of this study is that we have discovered a completely new process that regulates the adverse responses to bad memories," Reinscheid said in a UCI news release. "These findings can help the development of new drugs to treat conditions in which people are haunted by persistent fears, such as post-traumatic stress disorder or other panic disorders."

Previous research has shown that erasing major negative experiences may require "new learning," such as exposure to the place where the bad experience occurred. This is the first study to identify specific neurons and molecules that eliminate fear memories from the brain.

More information

The U.S. National Institute of Mental Health has more about post-traumatic stress disorder.



-- Robert Preidt



SOURCE: University of California, Irvine, news release, July 30, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Vision restoration therapy shown to improve brain activity in brain injured patients
3. Clinical depression linked to abnormal emotional brain circuits
4. Brain imaging reveals breakdown of normal emotional processing
5. Brain cells work differently than previously thought
6. Vaccine Stops Alzheimers Brain Tangles
7. Research may unlock mystery of autisms origin in the brain
8. Scientists Spot Brains Free Will Center
9. Free will takes flight: how our brains respond to an approaching menace
10. Alcoholics With Cirrhosis Have More Brain Damage
11. Brain Lesions Predict MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2017)... ... 2017 , ... MEDsys Software Solutions, the leading provider of ... Home Care Agencies, has been awarded CIO Applications Magazine’s Top 25 Workflow Solution ... 1,000 agencies and multiple State Medicaid and Managed Care Programs. MEDsys has ...
(Date:7/27/2017)... (PRWEB) , ... July 27, 2017 , ... ... outsourced services, announces the internal promotion of Elrene Clinkscales to Vice President of ... Claims & Remittance Management, reporting to Derek Morkel, chief executive officer (CEO). , ...
(Date:7/27/2017)... ... 2017 , ... Healthy eating isn’t always easy. Currently, more than 80 percent of Americans fail ... overeat refined grains and sugar. This trend may help explain why the obesity rate seems ... obese. , As a culture, we seem to have food on the brain more. "We ...
(Date:7/27/2017)... ... July 27, 2017 , ... The Freedom from Cancer Startup ... around 117 breakthrough inventions from 55 institutions, including the National Institutes of Health ... Biomedical Imaging and Bioengineering), the United States Army, and more than fifty American ...
(Date:7/27/2017)... ... , ... Cremations recently surpassed traditional burials for the first time in the ... continue with over 70% of Americans projected to choose cremation by 2030. , In ... families to celebrate the life of a lost loved one in different ways using ...
Breaking Medicine News(10 mins):
(Date:7/20/2017)... Minn. , July 20, 2017  Prime Therapeutics LLC ... Jonathan Gavras , M.D., following today,s Institute for Clinical and ... report on the effectiveness and value of abuse-deterrent formulations ... on the policy roundtable at the meeting. ... not a material cost benefit to the use of abuse-deterrent ...
(Date:7/17/2017)... ORLANDO, Fla. , July 17, 2017  MedX ... - branded medical testing, strengthening and rehabilitation equipment, today ... Back Machine Program. MedX is considered the gold standard ... world leader in specialized medical strengthening equipment. ... into a lease with the physician or practice who ...
(Date:7/14/2017)... -- Endo International plc (NASDAQ: ENDP ) will announce ... of its senior management team will host a conference call and ... The dial-in number to access the call is ... the passcode is 45397076. Please dial in 10 minutes prior to ... A replay of the call will be available from August 8, ...
Breaking Medicine Technology: