Navigation Links
Brain Mechanism Can Turn Off Trauma of Bad Memories
Date:7/30/2008

Molecules that eliminate fear factor could lead to new panic disorder drugs

WEDNESDAY, July 30 (HealthDay News -- The brain mechanism that turns off traumatic feelings associated with bad memories has been identified by researchers at the University of California, Irvine, who said their finding may lead to the development of new drugs to treat panic disorders.

When a person suffers a traumatic experience, environmental cues often become associated with the bad experience. Subsequent exposure to the same cues can cause fear or even panic attacks, according to study author Rainer Reinscheid, an associate professor of pharmacology and pharmaceutical sciences.

The UCI team, along with colleagues from the University of Muenster in Germany, found that a protein called neuropeptide S (NPS) eliminates traumatic responses to bad memories by working on a group of neurons inside the amygdala, the brain region where negative memories are stored.

In experiments with mice exposed to situations that caused bad memories, the researchers found that blocking NPS receptors in the amygdala made traumatic responses to bad memories persist longer. But when the mice were treated with compounds that activated the NPS receptors, traumatic responses vanished sooner.

The findings are published in the July 31 issue of Neuron.

"The exciting part of this study is that we have discovered a completely new process that regulates the adverse responses to bad memories," Reinscheid said in a UCI news release. "These findings can help the development of new drugs to treat conditions in which people are haunted by persistent fears, such as post-traumatic stress disorder or other panic disorders."

Previous research has shown that erasing major negative experiences may require "new learning," such as exposure to the place where the bad experience occurred. This is the first study to identify specific neurons and molecules that eliminate fear memories from the brain.

More information

The U.S. National Institute of Mental Health has more about post-traumatic stress disorder.



-- Robert Preidt



SOURCE: University of California, Irvine, news release, July 30, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Vision restoration therapy shown to improve brain activity in brain injured patients
3. Clinical depression linked to abnormal emotional brain circuits
4. Brain imaging reveals breakdown of normal emotional processing
5. Brain cells work differently than previously thought
6. Vaccine Stops Alzheimers Brain Tangles
7. Research may unlock mystery of autisms origin in the brain
8. Scientists Spot Brains Free Will Center
9. Free will takes flight: how our brains respond to an approaching menace
10. Alcoholics With Cirrhosis Have More Brain Damage
11. Brain Lesions Predict MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... announces today that the University of Pittsburgh Medical Center (UPMC) will acquire QuikClot® ... Western Pennsylvania. , The program, developed in association with efforts by the American ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... leading physicians, Paul Yost, will begin serving as new board chair for Orange ... month. Yost will serve the remainder of soon-to-be former chair Mark Refowitz’s term, ...
(Date:3/28/2017)... ... 2017 , ... In its ongoing effort to educate consumers ... and published an informational resource that addresses frequently asked questions. , “ ... site’s team of third party administrator (TPA) contributors regularly receives as employers, benefit ...
(Date:3/28/2017)... Santa Monica, CA (PRWEB) , ... March 28, ... ... expert, Dr. Carson Liu of SkyLex Advanced Surgical, Inc. is thrilled to offer ... newest gastric balloon procedure, and this procedure adds to SkyLex Advanced Surgical’s ...
(Date:3/28/2017)... ... ... a common and unwelcomed occurrence in people of all ages, genders and ethnicities. Dermatologist Dr. ... of dealing with excess skin oil. “Oily skin is a challenge to many of my ... the oily shine while keeping the skin fresh and clean,” says Dr. Au. , What ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... 27, 2017   Pulmatrix, Inc . (NASDAQ: PULM), a ... serious pulmonary diseases, today announced that it has added two ... and asthma to its Scientific Advisory Board . ... Richard B. Moss , MD, former chief of the Pediatric ... Fibrosis Center at Stanford University, and ...
(Date:3/27/2017)... , March 27, 2017 ... to reach USD 16.0 billion by 2025, according to ... growing prevalence of chronic diseases is anticipated to be ... analyzers, which thereby widens the scope for growth during ... and bariatric population, which is highly susceptible to chronic ...
(Date:3/27/2017)... BOSTON , March 27, 2017  Allergan ... and Paratek Pharmaceuticals, Inc. (Nasdaq: PRTK), a biopharmaceutical ... innovative therapies based upon tetracycline chemistry, announced that ... the treatment of moderate to severe acne met ... a once-daily, oral, narrow spectrum tetracycline-derived antibiotic with ...
Breaking Medicine Technology: