Navigation Links
Brain 'Master Switch' May Control Appetite, Fertility

Mouse study shows genetic link to signals telling body when it's full, safe to mate

SUNDAY, Aug. 31 (HealthDay News) -- A new study has found a "master switch" in the brain of mice that helps control both body weight and fertility.

It is well known that body weight and fertility are related to each other: Women who are too thin, for example, often have trouble getting pregnant. Now, researchers at the Salk Institute for Biological Studies may have found one reason why.

For a study published ahead of print in the Aug. 31 online edition of Nature Medicine, researchers studied a gene known as TORC1 in mice.

By creating mice that lacked one or both copies of TORC1, the researchers found that the gene affected both body weight and fertility. Specifically, the mice without the gene looked fine at birth, but at about eight weeks, they began to gain weight and became persistently obese in adulthood. And, to the researchers surprise, both sexes of these mice were infertile.

"This gene is crucial to the daisy chain of signals that run between body fat and the brain," study author Marc Montminy, a professor in the Clayton Foundation Laboratories for Peptide Biology, said in a Salk Institute press release. "It likely plays a pivotal role in how much we, as humans, eat and whether we have offspring."

Montminy says that the TORC1 gene is just as important as the appetite-regulating hormone leptin, which turns on TORC1.

"Leptin tells the brain that times are good, your body is full, and that it is not necessary to eat more at the moment," said Montminy.

When leptin binds with its receptor in brain cells, it turns on TORC1, telling the body that it is well-fed and activating genes that suppress appetite and allow reproduction. When leptin is not activating the brain receptors, on the other hand, TORC1 is turned off, and the genes that suppress appetite and allow reproduction are inactive.

"Controlling appetite and reproduction together provides a big evolutionary advantage," Montminy said. "If there is no food, the brain believes the body should not reproduce, because without body fat, a baby's growth in the womb could be stunted, and without food to replenish the body's energy reserves, there will be nothing to feed the offspring."

The researchers also found that the mice that inherited only one TORC1 gene were able to reproduce but gained more weight than the normal mice.

"This suggests that half of the dose of TORC switch is enough to cause problems in leptin signaling in the brain, and it may be that subtle mutations in the TORC1 in humans could be responsible for an inheritable risk factor for gaining weight," said Montminy.

Montminy thinks that this research could lead to new therapies that tweak mutated and inefficient TORC genes.

"TORC1 is regulated by phosphate handling enzymes called kinases, and kinases often make for very good drug targets," he said.

More information

The American Society for Reproductive Medicine has more about weight and fertility.

-- Krisha McCoy

SOURCE: Salk Institute, news release, Aug. 31, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Vision restoration therapy shown to improve brain activity in brain injured patients
3. Clinical depression linked to abnormal emotional brain circuits
4. Brain imaging reveals breakdown of normal emotional processing
5. Brain cells work differently than previously thought
6. Vaccine Stops Alzheimers Brain Tangles
7. Research may unlock mystery of autisms origin in the brain
8. Scientists Spot Brains Free Will Center
9. Free will takes flight: how our brains respond to an approaching menace
10. Alcoholics With Cirrhosis Have More Brain Damage
11. Brain Lesions Predict MS Progression
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media ... Pro X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice ... X users can now reveal the media of their split screens with growing ...
(Date:6/26/2016)... ... 2016 , ... Quality metrics are proliferating in cancer care, and are derived ... eye of the beholder, according to experts who offered insights and commentary in the ... Care. For the full issue, click here . , For the American Society ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... the Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/24/2016)... ... , ... A recent article published June 14 on E Online ... on to state that individuals are now more comfortable seeking to undergo not only ... calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
Breaking Medicine Technology: