Navigation Links
Brain Develops Differently in Fragile X Syndrome
Date:5/6/2010

MRI scans reveal anatomical alterations in children with genetic disorder

THURSDAY, May 6 (HealthDay News) -- Brain development in very young boys with fragile X syndrome differs from that in boys without the genetic disorder, a new study has found.

Fragile X syndrome, which is triggered by a mutation in a gene on the X chromosome, is the leading cause of inherited intellectual disability and autism. Though the syndrome affects about one in every 4,000 people, males with the disorder experience more significant symptoms than females.

U.S. researchers used high-resolution MRI to monitor long-term changes that differentiated the brain anatomy of 41 boys with fragile X syndrome and a control group of 21 healthy boys and seven other children who were experiencing developmental delays not caused by fragile X syndrome.

Detailed images of the children's brains were first taken when they were 1 to 3 years old. Follow-up images were taken up to two years later. The first sets of images revealed that the children with fragile X syndrome had an overabundance of gray matter in some brain regions (caudate and thalamus) and a reduced amount of gray matter in a part of the cerebellum called the vermis.

The findings suggest that the genetic mutation had already started to cause identifiable, consistent alterations in brain development, perhaps even before birth, the study noted.

The researchers also found that other areas of the brain, such as the basal forebrain and many regions of the cerebral cortex, were the same in children with fragile X syndrome and those in the control group at the first imaging session. However, differences were seen two years later, which suggests that certain effects of the X chromosome mutation become evident only later in brain development.

The study findings were published online May 3 in the Proceedings of the National Academy of Sciences.

"A number of years ago, we saw new treatments [for fragile X syndrome] quickly coming down the line," Dr. Allan Reiss, a professor of psychiatry and behavioral sciences and radiology at the Stanford University School of Medicine and the study's senior author, said in a university news release. "We wanted to provide information that could be used to guide those treatments."

Knowing where and when fragile X syndrome affects brain development can help researchers monitor the effects of new treatments, Reiss explained.

More information

The U.S. Centers for Disease Control and Prevention has more about fragile X syndrome.



-- Robert Preidt



SOURCE: Stanford University, news release, May 3, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. How dark chocolate may guard against brain injury from stroke
2. Early Detection Makes a Difference in the Treatment of Brain Aneurysms
3. Savvy Mom TV™ Welcomes Dr. Cynthia R. Green, Ph.D. as their Brain Health Expert
4. Do unruptured brain vessel malformations need preventative surgery?
5. Lottery game helps to assess brain damage following stroke
6. Alzheimers memory problems originate with protein clumps floating in the brain, not amyloid plaques
7. Mediterranean Diet Helps Protect Aging Brain
8. How red wine may shield brain from stroke damage
9. SKyPRO Releases Public Beta of GWTalk at BrainShare
10. Brain Games Do Not Make You Smarter
11. NFL gives $1 million unrestricted gift to Boston University to study impact of brain injuries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2017)... ... 22, 2017 , ... The VA Maryland Health Care System ... awarded the Baltimore VA Medical Center, a division of the VA Maryland Health ... to promote waste reduction and promote recycling. Also, Practice Greenhealth has recognized ...
(Date:6/20/2017)... ... June 20, 2017 , ... TwelveStone Health Partners, ... a Nashville-based private equity firm, has invested $3.35 million in the company. ... and Claritas Capital offers the smart money, speed to market and accountability we ...
(Date:6/20/2017)... (PRWEB) , ... June 20, 2017 , ... ... health science curriculum , is pleased to announce a new online course entitled ... online course provides practical insights and evidence-based strategies for achieving optimal well-being and ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... that the introduction of school choice can promote economic development in economically distressed ... that has, according to the report, contributed to the economic development of the ...
(Date:6/20/2017)... ... 2017 , ... Leading dental clinicians, Drs. Ashlyn Price, Autumn Mayers and Ron ... Anatomage systems. With advanced digital images and modeling capabilities, the dentists identify all of ... restore oral health for those who are missing teeth in Midlothian, VA. ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... years ago today, the Monterey Pop Festival opened its gates ... Francisco "Summer of Love."  To celebrate the anniversary, Northern Light® ... market research portals that it will begin delivering to customers ... "Summer of Love (For Our Customers)."  ... Northern Light ...
(Date:6/14/2017)... WINSTON-SALEM, N.C. , June 14, 2017  In ... the Creative Startups pitch competition and came ... virtual reality platform is described by Forbes as "entering ... the American Medical Association as teaching "empathy to medical ... success, the startup was recently named a finalist for ...
(Date:6/11/2017)... 2017  Eli Lilly and Company (NYSE: LLY ... studies of galcanezumab, an investigational treatment for the prevention ... several key secondary endpoints for galcanezumab compared to placebo ... (EVOLVE-1, EVOLVE-2 and REGAIN) will be presented today at ... Boston . "The ...
Breaking Medicine Technology: