Navigation Links
Brain Cells Give New Clues to Alzheimer's

Protein plaques disperse a free radical that can damage neurons, scientists say

THURSDAY, April 2 (HealthDay News) -- By uncovering a mechanism that causes damage to brain synapses during Alzheimer's disease, researchers might have found a key to reducing or preventing nerve degeneration for these patients.

According to a report in the April 3 issue of Science, researchers at the U.S.-based Burnham Institute for Medical Research have shown that beta-amyloid protein "multimers" create excessive nitric oxide. This free radical then reacts with the protein Drp1, causing the fragmentation of mitochondria -- the cell's energy storehouses -- in the brain, a violent process that causes the neurodegeneration linked to Alzheimer's disease.

When mitochondria break apart, the reaction damages synapses leading to nerve cell death. As brain synapses are vital for learning and memory, any damage or malfunction of these message-carrying connections can lead to Alzheimer's and dementia. Multimers had also been previously linked to Alzheimer's disease.

"By identifying Drp1 as the protein responsible for synaptic injury, we now have a new target for developing drugs that may slow or stop the progression of Alzheimer's," study leader Dr. Stuart A. Lipton, director of the Del E. Webb Center for Neuroscience, Aging and Stem Cell Research, said in a news release issued by the Burnham Institute.

More information

The Alzheimer's Association has more about Alzheimer's disease.

-- Kevin McKeever

SOURCE: Burnham Institute, news release, April 2, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Neuroscientists demonstrate link between brainwave acticity and visual perception
2. Drug Improves Survival in Mice With Brain Tumors
3. Is intervention beneficial for brain vessel malformations?
4. Active Ingredient in Marijuana Kills Brain Cancer Cells
5. Rigorous Visual Training Teaches the Brain to See Again After Stroke
6. Blood test for brain injuries gains momentum
7. New insights into how brain responds to viral infection
8. CSHL neuroscientists propose project to comprehensively map mammalian brain circuits
9. Cardiums InnerCool Announces Journal of Neurotrauma Highlights Hypothermia Therapys Role in Post Cardiac Arrest, and Traumatic Brain and Spinal Cord Injury Patients
10. Angiogenesis inhibitor improves brain tumor survival by reducing edema
11. AIDS Drug Slows Spread of Deadly Childhood Brain Cancer
Post Your Comments:
Related Image:
Brain Cells Give New Clues to Alzheimer's
(Date:12/1/2015)... , ... December 01, 2015 , ... ... radiographic technicians must mark the film for accurate interpretation by the radiologist. The ... Fortunately, an inventor from Sacramento, Calif., has found a way to alleviate this ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... (BHCOE) today announced that the organization has awarded Education and Developmental Therapies (EDT), ... Distinguished Award. The award celebrates exceptional special needs providers that excel in synthesizing ...
(Date:12/1/2015)... , ... December 01, 2015 , ... Lutronic, a leading ... Clarity, the latest addition to the devices for sale in the United States. ... Alexandrite and long-pulsed 1064 nm Nd:YAG lasers, into a single platform that is easy ...
(Date:12/1/2015)... ... December 01, 2015 , ... XTC Semifinals 2016 ... semi-finalists to head to Las Vegas for CES 2016, the world’s largest Consumer Electronic ... Consumer Technology Association Gary Shapiro, Founding Partner of Pacific Investments Veronica Serra, and venture ...
(Date:12/1/2015)... , ... December 01, 2015 , ... Nurotron Biotechnology Co., ... its largest order to date. , The order will be from the China ... Venus Cochlear Implant System is an effective solution for children and adults suffering from ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... , Dec. 1, 2015  Athletic apparel ... founder have agreed to pay $1.35 million to ... advertised the company,s copper-infused compression clothing would relieve ... arthritis and other diseases. Tommie ... requires the company and its founder and chairman ...
(Date:12/1/2015)... , Dec. 1, 2015 Assurex Health, ... GeneSight® Psychotropic test giving healthcare providers an expanded range ... for patients suffering from depression, anxiety, bipolar disorder, ... health conditions. i .   ... With the addition of two new drug ...
(Date:12/1/2015)... Calif. , Dec. 1, 2015 ... products and services, announced today that it has been ... services organization. Members served by Novation will have access ... devices, sports bracing products and soft goods dedicated to ... --> The aging U.S. population, rising prevalence ...
Breaking Medicine Technology: