Navigation Links
Brain Cells Give New Clues to Alzheimer's

Protein plaques disperse a free radical that can damage neurons, scientists say

THURSDAY, April 2 (HealthDay News) -- By uncovering a mechanism that causes damage to brain synapses during Alzheimer's disease, researchers might have found a key to reducing or preventing nerve degeneration for these patients.

According to a report in the April 3 issue of Science, researchers at the U.S.-based Burnham Institute for Medical Research have shown that beta-amyloid protein "multimers" create excessive nitric oxide. This free radical then reacts with the protein Drp1, causing the fragmentation of mitochondria -- the cell's energy storehouses -- in the brain, a violent process that causes the neurodegeneration linked to Alzheimer's disease.

When mitochondria break apart, the reaction damages synapses leading to nerve cell death. As brain synapses are vital for learning and memory, any damage or malfunction of these message-carrying connections can lead to Alzheimer's and dementia. Multimers had also been previously linked to Alzheimer's disease.

"By identifying Drp1 as the protein responsible for synaptic injury, we now have a new target for developing drugs that may slow or stop the progression of Alzheimer's," study leader Dr. Stuart A. Lipton, director of the Del E. Webb Center for Neuroscience, Aging and Stem Cell Research, said in a news release issued by the Burnham Institute.

More information

The Alzheimer's Association has more about Alzheimer's disease.

-- Kevin McKeever

SOURCE: Burnham Institute, news release, April 2, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Neuroscientists demonstrate link between brainwave acticity and visual perception
2. Drug Improves Survival in Mice With Brain Tumors
3. Is intervention beneficial for brain vessel malformations?
4. Active Ingredient in Marijuana Kills Brain Cancer Cells
5. Rigorous Visual Training Teaches the Brain to See Again After Stroke
6. Blood test for brain injuries gains momentum
7. New insights into how brain responds to viral infection
8. CSHL neuroscientists propose project to comprehensively map mammalian brain circuits
9. Cardiums InnerCool Announces Journal of Neurotrauma Highlights Hypothermia Therapys Role in Post Cardiac Arrest, and Traumatic Brain and Spinal Cord Injury Patients
10. Angiogenesis inhibitor improves brain tumor survival by reducing edema
11. AIDS Drug Slows Spread of Deadly Childhood Brain Cancer
Post Your Comments:
Related Image:
Brain Cells Give New Clues to Alzheimer's
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
(Date:6/24/2016)... San Francisco, CA (PRWEB) , ... June 24, ... ... at CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has ... , self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016   Bay Area Lyme ... Dean Center for Tick Borne Illness , ... Rehabilitation, MIT Hacking Medicine, University of California, Berkeley, ... announced the five finalists of Lyme Innovation ... More than 100 scientists, clinicians, researchers, entrepreneurs, and ...
(Date:6/24/2016)... , June 24, 2016  American Respiratory Labs (ARL), a ... now able to perform sophisticated lung assessments in patients, homes, thanks ... Inc. Patients are no longer limited to having ... PRO ® , ARL patients like Jeanne R. of ... the comfort of her own home. ...
(Date:6/24/2016)... June 24, 2016  Arkis BioSciences, a leading ... and more durable cerebrospinal fluid treatments, today announced ... Series-A funding is led by Innova Memphis, followed ... other private investors.  Arkis, new financing will accelerate ... the market release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: