Navigation Links
Brachytherapy to treat cervical cancer declines in US, treatment associated with higher survival
Date:9/11/2013

Boston, MA A study by researchers at Brigham and Women's Hospital (BWH) found that brachytherapy treatment was associated with better cause-specific survival and overall survival in women with cervical cancer. The population-based analysis also revealed geographic disparities and decline in brachytherapy treatment in the United States. Brachytherapy is a type of cancer treatment in which radioactive implants are inserted directly into the tissue near the tumor site.

The study is published in the September 2013 issue of The International Journal of Radiation Oncology.

The researchers used the Surveillance, Epidemiology, and End Results (SEER) Database to identify 7,359 patients with advanced stage cervical cancer treated with external beam radiation therapy (EBRT) between 1988 and 2009. (The 18 SEER population-based registries cover approximately 28 percent of the US population and include Connecticut, New Jersey, Metropolitan Detroit, Iowa, New Mexico, Hawaii, Seattle, Utah, Alaska, San Francisco-Oakland, San Jose-Monterey, Los Angeles, Greater California, Kentucky, Louisiana, Metropolitan Atlanta, Rural Georgia, and Greater Georgia. The registries collect information about patient and tumor characteristics and first course of cancer-directed treatment.)

Of the 7,359 patients identified, the researchers found that 63 percent of these women received brachytherapy in combination with EBRT, and 37 percent received EBRT alone. Factors associated with higher odds of brachytherapy use included younger age, being married, earlier years of diagnosis, earlier stage and certain SEER regions.

Moreover, brachytherapy usage rate decreased from 83 percent in 1988 to 58 percent in 2009. There was a sharp decline from 43 percent to 23 percent in 2003. The researchers noted that the decline may be related to the decreasing incidence of cervical cancer and increased adoption of alternative treatment techniques, such as intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT).

In terms of patient survival, brachytherapy was associated with a higher four-year cause-specific survival (64.3 percent vs. 51.5 percent) and overall survival (58.2 percent vs. 46.2 percent) compared to EBRT alone. Brachytherapy treatment was also independently associated with better cause-specific survival and overall survival.

"The shift away from brachytherapy is concerning, and has directly lowered the survival rates of cervical cancer patients," said Akila Viswanathan, MD, MPH, director of BWH Gynecologic Radiation Oncology, senior study author. "High-quality brachytherapy must continue to be used, ideally with image-guidance, to maximize survival and minimize toxicity."

Brachytherapy is an important component of treatment that escalates the dose of radiation to the primary tumor while minimizing the dose to critical organs at risk. The standard treatment of locally advanced cervical cancer is EBRT with concurrent chemotherapy, followed by brachytherapy.


'/>"/>

Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital
Source:Eurekalert

Related medicine news :

1. 2 landmark studies report on success of using image-guided brachytherapy to treat cervical cancer
2. Global Brachytherapy Devices Market 2013 Report
3. Dennis R. Hill MD Announces Launch of High Dose Rate Brachytherapy of Prostate Cancer Website
4. Potential new technique for anticancer radiotherapy could provide alternative to brachytherapy
5. EcoBeauty Brand Lotus Moon Reformulates Skin Regen®, a Leading Organic Scar-Healing Treatment
6. Mount Sinai Grants Exclusive License to Plexcera Therapeutics to Develop Treatments for Farber Disease and Cystic Fibrosis
7. Native Remedy; Zion Health Announces Natural Hair Products for Color Treated Hair: Adama Minerals Now Available at Whole Foods Market in West Hartford, CT
8. Gulf Coast Spine Care Updates Pinched Nerve Treatment Options
9. Pregnancy Miracle Review Reveals Effective Infertility Treatment
10. Congratulations Congresswoman Maxine Waters for Being Named Co-chair of the Alzheimer’s Task Force;* Now it is Time to Broadly Implement the Treatment that Reverses and Stabilizes this Disease
11. Study Indicates Benefits of Stem Cells in Treating MS Declines With Donor’s Age
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... CA (PRWEB) , ... May 25, 2016 , ... CloudLIMS, ... Promising Pharma and Life Sciences Tech Solution Providers list of 2016 by CIOReview. , ... Promising Pharma and Life Sciences Tech Solution Providers 2016 has been concluded with. The ...
(Date:5/25/2016)... ... May 25, 2016 , ... The Global Wellness Summit (GWS) ... integrative medical wellness offerings of Europe, a continent that pioneered the medical/wellness concept for ... from numerous pioneers in medical wellness, including Henri Chenot, Founder of the Chenot Group, ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... The University ... Nursing and Health Professions. She will lead a team of more than 100 full-time ... will begin her role as dean in late August. , Baker comes to USF ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... has seen a significant spike in their clients' employee participation for their wellness ... health screening by implementing a high-deductible health plan with outcome-based deductible incentives. As ...
(Date:5/25/2016)... ... ... Stern Environmental Group , of Secaucus, New Jersey, working in conjunction ... Real Time Monitoring (RTM) Device. Stern Environmental Group will sell the first monitoring ... use in dormitories, shelters, and nursing homes for real time bedbug monitoring in May ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... May 23, 2016 Diplomat Pharmacy, Inc. (NYSE: DPLO) ... and Internship programs. The hands-on learning experience is a ... full-time, paid Fellowship and Internship ... . Fellows and interns are provided optional housing free ... at the Riverfront Residence Hall to foster ...
(Date:5/23/2016)... 23, 2016 Clarifying Vision - ... Monitoring, and Vision Care What can be ... going to grow at the fastest rates? This ... assessing data, trends, opportunities and prospects. ... Discover the most lucrative areas in the industry and ...
(Date:5/23/2016)... 23, 2016 Experts from various ... Medicine and the role of technology in innovative ... The First International Conference of VPS-Penn Medicine opened in ... and presence of Sheikh Nahyan bin Mubarak Al Nahyan, Minister ... Medicine, which helps provide personalized medicine and tailor-made healthcare in ...
Breaking Medicine Technology: